[Term] id: PR:P03372-1 name: estrogen receptor isoform 1 (human) def: "An estrogen receptor isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hESR1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P03372-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027721 ! estrogen receptor isoform 1 [Term] id: PR:000045630 name: estrogen receptor phosphorylated 1 (human) def: "An estrogen receptor (human) that has been phosphorylated at the position equivalent to Tyr-537 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Tyr-537, MOD:00048." [PMID:7539106, iPTMnet:P03372] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:7539106). Status=unreviewed. synonym: "hESR1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P03372-1, Tyr-537, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P03372 ! estrogen receptor (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P03372-3 name: estrogen receptor isoform h3 (human) def: "An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-3." [PRO:DNx, UniProtKB:P03372] comment: Category=organism-sequence. synonym: "hESR1/iso:h3" EXACT PRO-short-label [PRO:DNx] synonym: "estrogen receptor isoform ER46 (human)" EXACT [UniProtKB:P03372] synonym: "estrogen receptor isoform hER-alpha46 (human)" EXACT [UniProtKB:P03372] xref: UniProtKB:P03372-3 xref: Reactome:R-HSA-9020984 "PR:P03372-3 located_in GO:0005829" is_a: PR:P03372 ! estrogen receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000027776 name: estrogen receptor isoform 1 phosphorylated 4 (human) def: "An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD] comment: Category=organism-modification. Kinase=("MAPK14"; PR:Q16539; Thr-311). synonym: "pERalpha-Thr311" EXACT [] synonym: "hESR1/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P03372-1, Thr-311, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027775 ! estrogen receptor isoform 1 phosphorylated 4 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027778 name: estrogen receptor isoform 1 phosphorylated 5 (human) def: "An estrogen receptor isoform 1 phosphorylated 5 in human. UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD] comment: Category=organism-modification. synonym: "hESR1/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx] synonym: "pERalpha-Ser118-Ser167" EXACT [] synonym: "UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027777 ! estrogen receptor isoform 1 phosphorylated 5 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027756 name: estrogen receptor isoform 1 acetylated 1 (human) def: "An estrogen receptor isoform 1 acetylated 1 in human. UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD] comment: Category=organism-modification. Acetylase=("p300"; PR:000007102). synonym: "hESR1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx] synonym: "AcK266/268-ERalpha (human)" EXACT [] synonym: "ERalpha acetylated (human)" RELATED [] synonym: "UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027755 ! estrogen receptor isoform 1 acetylated 1 relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000027754 name: estrogen receptor isoform 1 phosphorylated 3 (human) def: "An estrogen receptor isoform 1 phosphorylated 3 in human. UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD] comment: Category=organism-modification. Kinase=("MAPK"; PR:000000019). synonym: "hESR1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P03372-1, Ser-118, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027753 ! estrogen receptor isoform 1 phosphorylated 3 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:P03372-4 name: estrogen receptor isoform h4 (human) def: "An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-4." [PRO:DNx, UniProtKB:P03372] comment: Category=organism-sequence. synonym: "hESR1/iso:h4" EXACT PRO-short-label [PRO:DNx] synonym: "estrogen receptor isoform ER36 (human)" EXACT [UniProtKB:P03372] synonym: "estrogen receptor isoform hER-alpha36 (human)" EXACT [UniProtKB:P03372] xref: UniProtKB:P03372-4 xref: Reactome:R-HSA-9020981 "PR:P03372-4 located_in GO:0005829" is_a: PR:P03372 ! estrogen receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000007204 name: estrogen receptor def: "A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ER" EXACT [] synonym: "ESR" RELATED Gene-based [] synonym: "ESR1" EXACT PRO-short-label [PRO:DNx] synonym: "Estr" RELATED Gene-based [] synonym: "Estra" RELATED Gene-based [] synonym: "NR3A1" RELATED Gene-based [] synonym: "ER-alpha" EXACT [] synonym: "estradiol receptor" EXACT [] synonym: "nuclear receptor subfamily 3 group A member 1" EXACT [] xref: IUPHARobj:620 is_a: PR:000000001 ! protein [Term] id: PR:000027726 name: estrogen receptor isoform 1 phosphorylated 2 (human) def: "An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD] comment: Category=organism-modification. Kinase=("ABL1"; PR:P00519). synonym: "hESR1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027725 ! estrogen receptor isoform 1 phosphorylated 2 relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000027724 name: estrogen receptor isoform 1 phosphorylated 1 (human) def: "An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD] comment: Category=organism-modification. Kinase=("IKBKE"; PR:Q14164). synonym: "hESR1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "phospho-ERalpha-Ser-167" EXACT [] synonym: "UniProtKB:P03372-1, Ser-167, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027723 ! estrogen receptor isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:P03372-2 name: estrogen receptor isoform h2 (human) def: "An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-2." [PRO:DNx, UniProtKB:P03372] comment: Category=organism-sequence. synonym: "hESR1/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "estrogen receptor isoform Short (human)" EXACT [UniProtKB:P03372] xref: UniProtKB:P03372-2 is_a: PR:P03372 ! estrogen receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P03372 name: estrogen receptor (human) def: "An estrogen receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P03372] comment: Category=organism-gene. synonym: "ESR" RELATED Gene-based [UniProtKB:P03372] synonym: "ESR1" RELATED Gene-based [UniProtKB:P03372] synonym: "NR3A1" RELATED Gene-based [UniProtKB:P03372] synonym: "hESR1" EXACT PRO-short-label [PRO:DNx] synonym: "ER (human)" EXACT [UniProtKB:P03372] synonym: "ER-alpha (human)" EXACT [UniProtKB:P03372] synonym: "estradiol receptor (human)" EXACT [UniProtKB:P03372] synonym: "nuclear receptor subfamily 3 group A member 1 (human)" EXACT [UniProtKB:P03372] xref: Reactome:R-HSA-446168 "PR:P03372 located_in GO:0005654" xref: Reactome:R-HSA-9020968 "PR:P03372 located_in GO:0005829" xref: DTO:00117511 xref: UniProtKB:P03372 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000007204 ! estrogen receptor relationship: has_gene_template HGNC:3467 ! ESR1 (human)