[Term]
id: PR:P28668-1
name: bifunctional glutamate/proline--tRNA ligase isoform A (fruit fly)
def: "A bifunctional glutamate/proline--tRNA ligase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28668-1." [PRO:DNx, UniProtKB:P28668]
comment: Category=organism-sequence.
synonym: "fly-EPRS1/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28668-1
is_a: PR:P28668 ! bifunctional glutamate/proline--tRNA ligase (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P28668-2
name: bifunctional glutamate/proline--tRNA ligase isoform B (fruit fly)
def: "A bifunctional glutamate/proline--tRNA ligase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28668-2." [PRO:DNx, UniProtKB:P28668]
comment: Category=organism-sequence.
synonym: "fly-EPRS1/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28668-2
is_a: PR:P28668 ! bifunctional glutamate/proline--tRNA ligase (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P07814
name: bifunctional glutamate/proline--tRNA ligase (human)
def: "A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "EPRS" RELATED Gene-based [UniProtKB:P07814]
synonym: "GLNS" RELATED Gene-based [UniProtKB:P07814]
synonym: "PARS" RELATED Gene-based [UniProtKB:P07814]
synonym: "QARS" RELATED Gene-based [UniProtKB:P07814]
synonym: "QPRS" RELATED Gene-based [UniProtKB:P07814]
synonym: "EPRS1" RELATED Gene-based [UniProtKB:P07814]
synonym: "PIG32" RELATED Gene-based [UniProtKB:P07814]
synonym: "hEPRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "glutamatyl-prolyl-tRNA synthetase (human)" EXACT [UniProtKB:P07814]
synonym: "bifunctional aminoacyl-tRNA synthetase (human)" BROAD [PRO:DNx]
synonym: "cell proliferation-inducing gene 32 protein (human)" EXACT [UniProtKB:P07814]
xref: Reactome:R-HSA-379649 "PR:P07814 located_in GO:0005829"
xref: UniProtKB:P07814
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007144 ! bifunctional glutamate/proline--tRNA ligase
relationship: has_gene_template HGNC:3418 ! EPRS1 (human)

[Term]
id: PR:000007144
name: bifunctional glutamate/proline--tRNA ligase
def: "A protein that is a translation product of the human EPRS1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "EPRS" RELATED Gene-based []
synonym: "GLNS" RELATED Gene-based []
synonym: "PARS" RELATED Gene-based []
synonym: "QARS" RELATED Gene-based []
synonym: "QPRS" RELATED Gene-based []
synonym: "EPRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "PIG32" RELATED Gene-based []
synonym: "bifunctional aminoacyl-tRNA synthetase" RELATED []
synonym: "cell proliferation-inducing gene 32 protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8CGC7-1
name: bifunctional glutamate/proline--tRNA ligase isoform 1 (mouse)
def: "A bifunctional glutamate/proline--tRNA ligase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mEPRS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8CGC7-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038719 ! bifunctional glutamate/proline--tRNA ligase isoform 1

[Term]
id: PR:Q8CGC7
name: bifunctional glutamate/proline--tRNA ligase (mouse)
def: "A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of mouse." [OMA:Q8CGC7, PMID:15489334, PRO:HJD]
comment: Category=organism-gene.
synonym: "Eprs" RELATED Gene-based [UniProtKB:Q8CGC7]
synonym: "Qprs" RELATED Gene-based [UniProtKB:Q8CGC7]
synonym: "Eprs1" RELATED Gene-based [UniProtKB:Q8CGC7]
synonym: "mEPRS" EXACT PRO-short-label [PRO:DNx]
synonym: "bifunctional aminoacyl-tRNA synthetase (mouse)" EXACT [UniProtKB:Q8CGC7]
xref: UniProtKB:Q8CGC7
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007144 ! bifunctional glutamate/proline--tRNA ligase
relationship: has_gene_template MGI:97838 ! Eprs (mouse)

[Term]
id: PR:P07814-1
name: bifunctional glutamate/proline--tRNA ligase isoform 1 (human)
def: "A bifunctional glutamate/proline--tRNA ligase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hEPRS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07814-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038719 ! bifunctional glutamate/proline--tRNA ligase isoform 1

[Term]
id: PR:Q23315
name: ZC434.5 (worm)
def: "A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of worm." [PANTHER:PTHR10119:SF11, PRO:DNx]
comment: Category=organism-gene.
synonym: "EPRS (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "CELE_ZC434.5" RELATED Gene-based [UniProtKB:Q23315]
xref: UniProtKB:Q23315
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000007144 ! bifunctional glutamate/proline--tRNA ligase
relationship: has_gene_template WormBase:WBGene00001337 ! ears-1 (worm)

[Term]
id: PR:P28668
name: bifunctional glutamate/proline--tRNA ligase (fruit fly)
def: "A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of fruit fly." [OMA:P28668, PANTHER:PTHR10119:SF11, PRO:DNx]
comment: Category=organism-gene.
synonym: "CG5394" RELATED Gene-based [UniProtKB:P28668]
synonym: "GluProRS" RELATED Gene-based [UniProtKB:P28668]
synonym: "fly-EPRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "Aats-glupro" RELATED Gene-based [UniProtKB:P28668]
synonym: "bifunctional aminoacyl-tRNA synthetase (fruit fly)" EXACT [UniProtKB:P28668]
xref: UniProtKB:P28668
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000007144 ! bifunctional glutamate/proline--tRNA ligase
relationship: has_gene_template FlyBase:FBgn0005674 ! GluProRS (fruit fly)

[Term]
id: PR:000037788
name: bifunctional glutamate/proline--tRNA ligase unphosphorylated 1 (human)
def: "A bifunctional glutamate/proline--tRNA ligase (human) that lacks phosphorylation on residues equivalent to Ser-886 and Ser-999 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Ser-886/Ser-999, PR:000026291." [PMID:19647514, PRO:CNA]
comment: Category=organism-modification.
synonym: "hEPRS/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mEPRS unphosphorylated" RELATED []
synonym: "UniProtKB:P07814, Ser-886/Ser-999, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P07814 ! bifunctional glutamate/proline--tRNA ligase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000038719
name: bifunctional glutamate/proline--tRNA ligase isoform 1
def: "A bifunctional glutamate/proline--tRNA ligase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07814-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "EPRS/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "bifunctional aminoacyl-tRNA synthetase isoform 1" BROAD [PRO:DNx]
is_a: PR:000007144 ! bifunctional glutamate/proline--tRNA ligase

[Term]
id: PR:000037785
name: bifunctional glutamate/proline--tRNA ligase phosphorylated 1 (mouse)
def: "A bifunctional glutamate/proline--tRNA ligase (mouse) that has been phosphorylated on a Ser residue in the noncatalytic linker connecting the synthetase cores in an IFN-gamma-dependent manner. UniProtKB:Q8CGC7, Ser-999, MOD:00046." [PMID:23071094, PRO:HJD]
comment: Category=organism-modification.
synonym: "mEPRS/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "mEPRS phosphorylated" RELATED []
synonym: "UniProtKB:Q8CGC7, Ser-999, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8CGC7 ! bifunctional glutamate/proline--tRNA ligase (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000037787
name: bifunctional glutamate/proline--tRNA ligase phosphorylated 1 (human)
def: "A bifunctional glutamate/proline--tRNA ligase (human) that has been phosphorylated on two Ser residues in the noncatalytic linker connecting the synthetase cores in an IFN-gamma-dependent manner. The first site conforms to the motif [ST]Px[KR]. UniProtKB:P07814, Ser-886/Ser-999, MOD:00046." [PMID:19647514, PRO:CNA]
comment: Category=organism-modification. Kinase=("AGC group kinase"; Ser-999). Kinase=("Pro-directed kinase"; Ser-886).
synonym: "hEPRS/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mEPRS phosphorylated" RELATED []
synonym: "UniProtKB:P07814, Ser-886/Ser-999, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P07814 ! bifunctional glutamate/proline--tRNA ligase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000037786
name: bifunctional glutamate/proline--tRNA ligase unphosphorylated 1 (mouse)
def: "A bifunctional glutamate/proline--tRNA ligase (mouse) that lacks phosphorylation at the position equivalent to Ser-999 of the amino acid sequence represented by UniProtKB:Q8CGC7. UniProtKB:Q8CGC7, Ser-999, PR:000026291." [PMID:23071094, PRO:HJD]
comment: Category=organism-modification.
synonym: "mEPRS/UnPhos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "mEPRS unphosphorylated" RELATED []
synonym: "UniProtKB:Q8CGC7, Ser-999, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8CGC7 ! bifunctional glutamate/proline--tRNA ligase (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus