[Term]
id: PR:000037787
name: bifunctional glutamate/proline--tRNA ligase phosphorylated 1 (human)
def: "A bifunctional glutamate/proline--tRNA ligase (human) that has been phosphorylated on two Ser residues in the noncatalytic linker connecting the synthetase cores in an IFN-gamma-dependent manner. The first site conforms to the motif [ST]Px[KR]. UniProtKB:P07814, Ser-886/Ser-999, MOD:00046." [PMID:19647514, PRO:CNA]
comment: Category=organism-modification. Kinase=("AGC group kinase"; Ser-999). Kinase=("Pro-directed kinase"; Ser-886).
synonym: "hEPRS/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mEPRS phosphorylated" RELATED []
synonym: "UniProtKB:P07814, Ser-886/Ser-999, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P07814 ! bifunctional glutamate/proline--tRNA ligase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07814
name: bifunctional glutamate/proline--tRNA ligase (human)
def: "A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "EPRS" RELATED Gene-based [UniProtKB:P07814]
synonym: "GLNS" RELATED Gene-based [UniProtKB:P07814]
synonym: "PARS" RELATED Gene-based [UniProtKB:P07814]
synonym: "QARS" RELATED Gene-based [UniProtKB:P07814]
synonym: "QPRS" RELATED Gene-based [UniProtKB:P07814]
synonym: "EPRS1" RELATED Gene-based [UniProtKB:P07814]
synonym: "PIG32" RELATED Gene-based [UniProtKB:P07814]
synonym: "hEPRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "glutamatyl-prolyl-tRNA synthetase (human)" EXACT [UniProtKB:P07814]
synonym: "bifunctional aminoacyl-tRNA synthetase (human)" BROAD [PRO:DNx]
synonym: "cell proliferation-inducing gene 32 protein (human)" EXACT [UniProtKB:P07814]
xref: Reactome:R-HSA-379649 "PR:P07814 located_in GO:0005829"
xref: UniProtKB:P07814
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007144 ! bifunctional glutamate/proline--tRNA ligase
relationship: has_gene_template HGNC:3418 ! EPRS1 (human)

[Term]
id: PR:000007144
name: bifunctional glutamate/proline--tRNA ligase
def: "A protein that is a translation product of the human EPRS1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "EPRS" RELATED Gene-based []
synonym: "GLNS" RELATED Gene-based []
synonym: "PARS" RELATED Gene-based []
synonym: "QARS" RELATED Gene-based []
synonym: "QPRS" RELATED Gene-based []
synonym: "EPRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "PIG32" RELATED Gene-based []
synonym: "bifunctional aminoacyl-tRNA synthetase" RELATED []
synonym: "cell proliferation-inducing gene 32 protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000037788
name: bifunctional glutamate/proline--tRNA ligase unphosphorylated 1 (human)
def: "A bifunctional glutamate/proline--tRNA ligase (human) that lacks phosphorylation on residues equivalent to Ser-886 and Ser-999 of the amino acid sequence represented by UniProtKB:P07814. UniProtKB:P07814, Ser-886/Ser-999, PR:000026291." [PMID:19647514, PRO:CNA]
comment: Category=organism-modification.
synonym: "hEPRS/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mEPRS unphosphorylated" RELATED []
synonym: "UniProtKB:P07814, Ser-886/Ser-999, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P07814 ! bifunctional glutamate/proline--tRNA ligase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07814-1
name: bifunctional glutamate/proline--tRNA ligase isoform 1 (human)
def: "A bifunctional glutamate/proline--tRNA ligase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hEPRS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07814-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038719 ! bifunctional glutamate/proline--tRNA ligase isoform 1