[Term]
id: PR:Q9WUA5
name: laforin (mouse)
def: "A laforin that is encoded in the genome of mouse." [OMA:Q9WUA5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Epm2a" RELATED Gene-based [UniProtKB:Q9WUA5]
synonym: "mEPM2A" EXACT PRO-short-label [PRO:DNx]
synonym: "LAFPTPase (mouse)" EXACT [UniProtKB:Q9WUA5]
synonym: "lafora PTPase (mouse)" EXACT [UniProtKB:Q9WUA5]
synonym: "glucan phosphatase (mouse)" EXACT [UniProtKB:Q9WUA5]
xref: UniProtKB:Q9WUA5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007136 ! laforin
relationship: has_gene_template MGI:1341085 ! Epm2a (mouse)

[Term]
id: PR:000007136
name: laforin
def: "A protein that is a translation product of the human EPM2A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "EPM2A" EXACT PRO-short-label [PRO:DNx]
synonym: "LAFPTPase" EXACT []
synonym: "lafora PTPase" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000045617
name: laforin isoforms 1/2/4/5/6/7/8 phosphorylated 1 (human)
def: "A laforin isoforms 1/2/4/5/6/7/8 (human) that has been phosphorylated at the position equivalent to Ser-25 of the amino acid sequence represented by UniProtKB:O95278-1. Example: UniProtKB:O95278-1, Ser-25, MOD:00046." [PMID:21728993, iPTMnet:O95278]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21728993). Status=unreviewed.
synonym: "hEPM2A/iso:[1/2/4/5/6/7/8]/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O95278-1, Ser-25, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O95278 ! laforin isoforms 1/2/4/5/6/7/8 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047312
name: laforin ubiquitinated form (human)
def: "A laforin (human) that includes at least one ubiquitinated lysine. UniProtKB:O95278, MOD:01148." [PRO:DNx, Reactome:R-HSA-3781004]
comment: Category=organism-modification.
synonym: "hEPM2A/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O95278, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3781004 "PR:000047312 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:000030063 ! laforin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95278
name: laforin isoforms 1/2/4/5/6/7/8 (human)
def: "A laforin (human), isoforms 1, 2, 4, 5, 6, 7, and 8." [PRO:DAN, UniProtKB:O95278]
comment: Category=organism-seqgroup.
synonym: "hEPM2A/iso:[1/2/4/5/6/7/8]" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-3777103 "PR:O95278 located_in GO:0005829"
xref: UniProtKB:O95278
is_a: PR:000030063 ! laforin (human)
union_of: PR:O95278-1 ! laforin isoform 1 (human)
union_of: PR:O95278-2 ! laforin isoform 2 (human)
union_of: PR:O95278-4 ! laforin isoform 4 (human)
union_of: PR:O95278-5 ! laforin isoform 5 (human)
union_of: PR:O95278-6 ! laforin isoform 6 (human)
union_of: PR:O95278-7 ! laforin isoform 7 (human)
union_of: PR:O95278-8 ! laforin isoform 8 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q91XQ2
name: laforin (rat)
def: "A laforin that is encoded in the genome of rat." [OMA:Q91XQ2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Epm2a" RELATED Gene-based [UniProtKB:Q91XQ2]
synonym: "rEPM2A" EXACT PRO-short-label [PRO:DNx]
synonym: "LAFPTPase (rat)" EXACT [UniProtKB:Q91XQ2]
synonym: "lafora PTPase (rat)" EXACT [UniProtKB:Q91XQ2]
synonym: "glucan phosphatase (rat)" EXACT [UniProtKB:Q91XQ2]
xref: UniProtKB:Q91XQ2
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000007136 ! laforin
relationship: has_gene_template RGD:71047 ! Epm2a (rat)

[Term]
id: PR:B3EWF7-1
name: laforin, isoform 9 (human)
alt_id: PR:B3EWF7
def: "A laforin, isoform 9 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hEPM2A/iso:9" EXACT PRO-short-label [PRO:DNx]
synonym: "laforin, isoform POCR (human)" EXACT [UniProtKB:B3EWF7]
xref: UniProtKB:B3EWF7-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000030436 ! laforin, isoform 9

[Term]
id: PR:Q5ZL46
name: protein-tyrosine-phosphatase (chicken)
def: "A laforin that is encoded in the genome of chicken." [PRO:DNx]
comment: Category=organism-gene.
synonym: "EPM2A" RELATED Gene-based [UniProtKB:Q5ZL46]
synonym: "chick-EPM2A" EXACT PRO-short-label [PRO:DNx]
synonym: "RCJMB04_7n21" RELATED Gene-based [UniProtKB:Q5ZL46]
xref: UniProtKB:Q5ZL46
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000007136 ! laforin
relationship: has_gene_template CGNC:9323 ! EPM2A (chicken)

[Term]
id: PR:O95278-8
name: laforin isoform 8 (human)
def: "A laforin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95278-8." [PRO:DNx, UniProtKB:O95278]
comment: Category=organism-sequence.
synonym: "hEPM2A/iso:8" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O95278-8
is_a: PR:000030063 ! laforin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95278-2
name: laforin isoform 2 (human)
def: "A laforin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95278-2." [PRO:DNx, UniProtKB:O95278]
comment: Category=organism-sequence.
synonym: "hEPM2A/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "laforin isoform B (human)" EXACT [UniProtKB:O95278]
synonym: "laforin isoform laf317 (human)" EXACT [UniProtKB:O95278]
synonym: "laforin isoform C-terISO (human)" EXACT [UniProtKB:O95278]
xref: UniProtKB:O95278-2
is_a: PR:000030063 ! laforin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95278-4
name: laforin isoform 4 (human)
def: "A laforin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95278-4." [PRO:DNx, UniProtKB:O95278]
comment: Category=organism-sequence.
synonym: "hEPM2A/iso:4" EXACT PRO-short-label [PRO:DNx]
synonym: "laforin isoform laf152 (human)" EXACT [UniProtKB:O95278]
xref: UniProtKB:O95278-4
is_a: PR:000030063 ! laforin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95278-5
name: laforin isoform 5 (human)
def: "A laforin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95278-5." [PRO:DNx, UniProtKB:O95278]
comment: Category=organism-sequence.
synonym: "hEPM2A/iso:5" EXACT PRO-short-label [PRO:DNx]
synonym: "laforin isoform laf224 (human)" EXACT [UniProtKB:O95278]
xref: UniProtKB:O95278-5
is_a: PR:000030063 ! laforin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95278-6
name: laforin isoform 6 (human)
def: "A laforin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95278-6." [PRO:DNx, UniProtKB:O95278]
comment: Category=organism-sequence.
synonym: "hEPM2A/iso:6" EXACT PRO-short-label [PRO:DNx]
synonym: "laforin isoform laf88 (human)" EXACT [UniProtKB:O95278]
xref: UniProtKB:O95278-6
is_a: PR:000030063 ! laforin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95278-7
name: laforin isoform 7 (human)
def: "A laforin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95278-7." [PRO:DNx, UniProtKB:O95278]
comment: Category=organism-sequence.
synonym: "hEPM2A/iso:7" EXACT PRO-short-label [PRO:DNx]
synonym: "laforin isoform laf177 (human)" EXACT [UniProtKB:O95278]
xref: UniProtKB:O95278-7
is_a: PR:000030063 ! laforin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000030436
name: laforin, isoform 9
def: "A laforin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B3EWF7-1 or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=sequence.
synonym: "POCR" EXACT []
synonym: "EPM2A/iso:9" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000007136 ! laforin

[Term]
id: PR:O95278-1
name: laforin isoform 1 (human)
def: "A laforin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95278-1." [PRO:DNx, UniProtKB:O95278]
comment: Category=organism-sequence.
synonym: "hEPM2A/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "laforin isoform A (human)" EXACT [UniProtKB:O95278]
synonym: "laforin isoform LDH1 (human)" EXACT [UniProtKB:O95278]
synonym: "laforin isoform laf331 (human)" EXACT [UniProtKB:O95278]
xref: UniProtKB:O95278-1
is_a: PR:000030063 ! laforin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000030063
name: laforin (human)
def: "A laforin that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-gene.
synonym: "hEPM2A" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007136 ! laforin
relationship: has_gene_template HGNC:3413 ! EPM2A (human)