[Term]
id: PR:000037244
name: chymotrypsin-like elastase family member 2A, pro-form (mouse)
def: "A chymotrypsin-like elastase family member 2A, signal peptide removed form in mouse. UniProtKB:P05208, 17-271." [PMID:20179351, PRO:KRC]
comment: Category=organism-modification. Note: Figure 3 (C) Western blot analysis of WT and Tg-ELA2 (Tg) epidermal and dermal extracts, using an anti-FLAG antibody, reveals exogenous ELA2flag as pro-forms and active forms in the epidermis of transgenic animals. Start site of pro-form (lacking signal peptide) is inferred by curator from UniProt record.
synonym: "mCELA2A/pro" EXACT PRO-short-label [PRO:DAN]
synonym: "pro-Ela2 (mouse)" EXACT []
synonym: "pro-Cela2a (mouse)" EXACT []
synonym: "pro-elastase 2 (mouse)" EXACT []
synonym: "UniProtKB:P05208, 17-271" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "chymotrypsin-like elastase family member 2A, signal peptide removed form (mouse)" EXACT []
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000019775 ! chymotrypsin-like elastase family member 2A, signal peptide removed form

[Term]
id: PR:000037245
name: chymotrypsin-like elastase family member 2A, mature form (mouse)
def: "A chymotrypsin-like elastase family member 2A, pro-form (mouse) that has had the activation peptide removed by proteolytic cleavage. UniProtKB:P05208, 31-271." [PMID:20179351, PMID:3641189, PRO:KRC]
comment: Category=organism-modification. Note: Figure 3C in PMID:20179351 shows the Western blot analysis of WT and Tg-ELA2 (Tg) epidermal and dermal extracts, using an anti-FLAG antibody, revealing exogenous ELA2flag as pro-forms and active forms in the epidermis of transgenic animals. Figure 1 in PMID:3641189 shows sequence of mRNA corresponding to preproenzyme and presumes start site of active enzyme based on homology with porcine enzyme.
synonym: "Ela2 (mouse)" RELATED []
synonym: "Cela2a (mouse)" RELATED []
synonym: "PRO_0000027688" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "mCELA2A/mature" EXACT PRO-short-label [PRO:DAN]
synonym: "elastase 2 (mouse)" RELATED []
synonym: "UniProtKB:P05208, 31-271" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: PR:000037244 ! chymotrypsin-like elastase family member 2A, pro-form (mouse)
intersection_of: lacks_part SO:0001062 ! propeptide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000037243
name: chymotrypsin-like elastase family member 2A, precursor (mouse)
def: "A chymotrypsin-like elastase family member 2A, full-length form in mouse." [PMID:3641189, PRO:KRC]
comment: Category=organism-modification.
synonym: "mCELA2A/pre-pro" EXACT PRO-short-label [PRO:DAN]
synonym: "prepro-Ela2 (mouse)" EXACT []
synonym: "prepro-Cela2a (mouse)" EXACT []
synonym: "prepro-elastase 2 (mouse)" EXACT []
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000019774 ! chymotrypsin-like elastase family member 2A, full-length form

[Term]
id: PR:000007010
name: chymotrypsin-like elastase family member 2A
def: "A trypsin that is a translation product of the human CELA2A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Ela2" RELATED Gene-based []
synonym: "ELA2A" RELATED Gene-based []
synonym: "Ela-2" RELATED Gene-based []
synonym: "CELA2A" EXACT PRO-short-label [PRO:DNx]
synonym: "elastase-2" BROAD [PRO:DNx]
synonym: "elastase-2A" EXACT []
is_a: PR:000027795 ! trypsin

[Term]
id: PR:P05208
name: chymotrypsin-like elastase family member 2A (mouse)
def: "A chymotrypsin-like elastase family member 2A that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-gene.
synonym: "Ela2" RELATED Gene-based [UniProtKB:P05208]
synonym: "Ela-2" RELATED Gene-based [UniProtKB:P05208]
synonym: "Ela2a" RELATED Gene-based [UniProtKB:P05208]
synonym: "Cela2a" RELATED Gene-based [UniProtKB:P05208]
synonym: "mCELA2A" EXACT PRO-short-label [PRO:DNx]
synonym: "elastase-2 (mouse)" EXACT [UniProtKB:P05208]
synonym: "elastase-2A (mouse)" EXACT [UniProtKB:P05208]
xref: UniProtKB:P05208
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007010 ! chymotrypsin-like elastase family member 2A
relationship: has_gene_template MGI:95316 ! Cela2a (mouse)

[Term]
id: PR:P05208-1
name: chymotrypsin-like elastase family member 2A isoform 1 (mouse)
def: "A chymotrypsin-like elastase family member 2A isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mCELA2A/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05208-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038672 ! chymotrypsin-like elastase family member 2A isoform 1