[Term]
id: PR:Q13541
name: eukaryotic translation initiation factor 4E-binding protein 1 (human)
def: "A eukaryotic translation initiation factor 4E-binding protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13541]
comment: Category=organism-gene.
synonym: "EIF4EBP1" RELATED Gene-based [UniProtKB:Q13541]
synonym: "hEIF4EBP1" EXACT PRO-short-label [PRO:DNx]
synonym: "4E-BP1 (human)" EXACT [UniProtKB:Q13541]
synonym: "PHAS-I (human)" EXACT [UniProtKB:Q13541]
synonym: "eIF4E-binding protein 1 (human)" EXACT [UniProtKB:Q13541]
synonym: "phosphorylated heat- and acid-stable protein regulated by insulin 1 (human)" EXACT [UniProtKB:Q13541]
xref: UniProtKB:Q13541
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006994 ! eukaryotic translation initiation factor 4E-binding protein 1
relationship: has_gene_template HGNC:3288 ! EIF4EBP1 (human)

[Term]
id: PR:000006994
name: eukaryotic translation initiation factor 4E-binding protein 1
def: "A protein that is a translation product of the human EIF4EBP1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "4E-BP1" EXACT []
synonym: "PHAS-I" EXACT []
synonym: "EIF4EBP1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF4E-binding protein 1" EXACT []
synonym: "phosphorylated heat- and acid-stable protein regulated by insulin 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000044855
name: eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed acetylated and phosphorylated 2 (human)
def: "A eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form (human) that is acetylated at the N-terminal Ser and phosphorylated on Ser-94 and Ser-101. UniProtKB:Q13541, 2-118, Ser-2, MOD:00060|Ser-94/Ser-101, MOD:00046." [TDR:2642]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "hEIF4EBP1/InitMet-/AcPhos:2" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000190513, Ser-2, MOD:00060|Ser-94/Ser-101, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q13541, 2-118, Ser-2, MOD:00060|Ser-94/Ser-101, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:2642
is_a: PR:000028425 ! eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00060 ! N-acetyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035490
name: eukaryotic translation initiation factor 4E-binding protein 1 phosphorylated 1 (human)
def: "A eukaryotic translation initiation factor 4E-binding protein 1 phosphorylated 1 in human." [PMID:10198256, PRO:KER]
comment: Category=organism-modification. Kinase=("BUB1"; PR:O43683).
synonym: "hEIF4EBP1/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035489 ! eukaryotic translation initiation factor 4E-binding protein 1 phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000044853
name: eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed acetylated 1 (human)
def: "A eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form (human) that is acetylated at the N-terminal Ser. UniProtKB:Q13541, 2-118, Ser-2, MOD:00060." [PRO:DAN, TDR:2130]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "hEIF4EBP1/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000190513, Ser-2, MOD:00060" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q13541, 2-118, Ser-2, MOD:00060" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:2130
is_a: PR:000028425 ! eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form (human)
relationship: has_part MOD:00060 ! N-acetyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026216
name: eukaryotic translation initiation factor 4E-binding protein 1 isoform 1 phosphorylated 1 (human)
def: "A eukaryotic translation initiation factor 4E-binding protein 1 isoform 1 phosphorylated 1 in human. UniProtKB:Q13541-1, 2-118, Thr-37/Thr-46, MOD:00047." [PRO:CNx, Reactome:R-HSA-165685]
comment: Category=organism-modification.
synonym: "hEIF4EBP1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000190513, Thr-37/Thr-46, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q13541-1, 2-118, Thr-37/Thr-46, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-165685 "PR:000026216 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026206 ! eukaryotic translation initiation factor 4E-binding protein 1 isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000044854
name: eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed acetylated and phosphorylated 1 (human)
def: "A eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form (human) that is acetylated at the N-terminal Ser and phosphorylated on Ser-94. UniProtKB:Q13541, 2-118, Ser-2, MOD:00060|Ser-94, MOD:00046." [PRO:DAN, TDR:2640]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "hEIF4EBP1/InitMet-/AcPhos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000190513, Ser-2, MOD:00060|Ser-94, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q13541, 2-118, Ser-2, MOD:00060|Ser-94, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:2640
is_a: PR:000028425 ! eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00060 ! N-acetyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028425
name: eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form (human)
def: "A eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form in human. UniProtKB:Q13541, 2-118." [PRO:DNx]
comment: Category=organism-modification.
synonym: "PRO_0000190513" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hEIF4EBP1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13541, 2-118" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-72580 "PR:000028425 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000019769 ! eukaryotic translation initiation factor 4E-binding protein 1, initiator methionine removed form

[Term]
id: PR:Q13541-1
name: eukaryotic translation initiation factor 4E-binding protein 1 isoform 1 (human)
def: "A eukaryotic translation initiation factor 4E-binding protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "hEIF4EBP1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13541-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026204 ! eukaryotic translation initiation factor 4E-binding protein 1 isoform 1