[Term]
id: PR:P41374
name: eukaryotic translation initiation factor 2 subunit 1 (fruit fly)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of fruit fly." [OMA:P41374, PANTHER:PTHR10602:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "eIF2a" RELATED Gene-based [UniProtKB:P41374]
synonym: "CG9946" RELATED Gene-based [UniProtKB:P41374]
synonym: "eIF2alpha" RELATED Gene-based [UniProtKB:P41374]
synonym: "eIF2-alpha" RELATED Gene-based [UniProtKB:P41374]
synonym: "fly-EIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2-alpha (fruit fly)" EXACT [UniProtKB:P41374]
synonym: "eukaryotic translation initiation factor 2 subunit alpha (fruit fly)" EXACT [UniProtKB:P41374]
xref: UniProtKB:P41374
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template FlyBase:FBgn0261609 ! eIF2alpha (fruit fly)

[Term]
id: PR:000047266
name: eukaryotic translation initiation factor 2 subunit 1 phosphorylated 1 (human)
def: "A eukaryotic translation initiation factor 2 subunit 1 (human) that has been post-translationally modified to include phosphoserine at position 52 of the amino acid sequence represented by UniProtKB:P05198. UniProtKB:P05198, Ser-52, MOD:00046." [PRO:DNx, Reactome:R-HSA-381060]
comment: Category=organism-modification.
synonym: "hEIF2S1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05198, Ser-52, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-381060 "PR:000047266 located_in GO:0005829"
is_a: PR:P05198 ! eukaryotic translation initiation factor 2 subunit 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q869N9
name: eukaryotic translation initiation factor 2 subunit 1 (Dictyostelium discoideum)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q869N9, PANTHER:PTHR10602:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "eif2a" RELATED Gene-based [UniProtKB:Q869N9]
synonym: "eif2s1" RELATED Gene-based [UniProtKB:Q869N9]
synonym: "DDB_G0271862" RELATED Gene-based [UniProtKB:Q869N9]
synonym: "Dicty-EIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2-alpha (Dictyostelium discoideum)" EXACT [UniProtKB:Q869N9]
synonym: "eukaryotic translation initiation factor 2 subunit alpha (Dictyostelium discoideum)" EXACT [UniProtKB:Q869N9]
xref: UniProtKB:Q869N9
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template dictyBase:DDB_G0271862 ! eif2s1 (Dictyostelium discoideum)

[Term]
id: PR:000050562
name: eukaryotic translation initiation factor 2 subunit alpha phosphorylated 1 (Schizosaccharomyces pombe)
def: "A eukaryotic translation initiation factor 2 subunit alpha (Schizosaccharomyces pombe) that has been phosphorylated at the position equivalent to Ser-52 of the amino acid sequence represented by UniProtKB:P56286. UniProtKB:P56286, Ser-52, MOD:00046." [PMID:28771613, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested_by=PomBase. Kinase=("GCN2"; PR:000050561; Ser-52).
synonym: "Spom-EIF2S1/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P56286, Ser-52, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P56286-1, Ser-52, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000050560 ! eukaryotic translation initiation factor 2 subunit alpha (Schizosaccharomyces pombe)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe

[Term]
id: PR:000044811
name: eukaryotic translation initiation factor 2 subunit 1 isoform 1 hyperphosphorylated form (mouse)
def: "A eukaryotic translation initiation factor 2 subunit 1 isoform 1 (mouse) that is hyperphosphorylated. UniProtKB:Q6ZWX6-1, MOD:00696." [PMID:18996085, PRO:KRC]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18996085). Note: PMID:18996085 - They show by Western blot that eIF2a is hyperphosphorylated in mature oocytes.
synonym: "mEIF2S1/iso:1/HyperPhos+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q6ZWX6-1, MOD:00696" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "eIF2a phosphorylated 1 (mouse)" EXACT []
synonym: "eIF2a hyperphosphorylated (mouse)" RELATED []
is_a: PR:Q6ZWX6-1 ! eukaryotic translation initiation factor 2 subunit 1 isoform 1 (mouse)
relationship: has_part MOD:00696 ! phosphorylated residue
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000006971
name: eukaryotic translation initiation factor 2 subunit 1
def: "A protein that is a translation product of the human EIF2S1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "EIF2A" RELATED Gene-based []
synonym: "EIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2A" RELATED []
synonym: "eIF-2alpha" EXACT []
synonym: "eIF-2-alpha" EXACT []
synonym: "eukaryotic translation initiation factor 2 subunit alpha" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P05198-1
name: eukaryotic translation initiation factor 2 subunit 1 isoform 1 (human)
def: "A eukaryotic translation initiation factor 2 subunit 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hEIF2S1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05198-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026238 ! eukaryotic translation initiation factor 2 subunit 1 isoform 1

[Term]
id: PR:000026238
name: eukaryotic translation initiation factor 2 subunit 1 isoform 1
def: "A eukaryotic translation initiation factor 2 subunit 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6ZWX6-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "EIF2S1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1

[Term]
id: PR:Q6ZWX6-1
name: eukaryotic translation initiation factor 2 subunit 1 isoform 1 (mouse)
def: "A eukaryotic translation initiation factor 2 subunit 1 isoform 1 that is encoded in the genome of mouse." [PMID:16141072, PMID:17596516, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mEIF2S1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q6ZWX6-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026238 ! eukaryotic translation initiation factor 2 subunit 1 isoform 1

[Term]
id: PR:P20459
name: eukaryotic translation initiation factor 2 subunit alpha (yeast)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of yeast." [OMA:P20459, PANTHER:PTHR10602:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "SUI2" RELATED Gene-based [UniProtKB:P20459]
synonym: "J1429" RELATED Gene-based [UniProtKB:P20459]
synonym: "TIF211" RELATED Gene-based [UniProtKB:P20459]
synonym: "YJR007W" RELATED Gene-based [UniProtKB:P20459]
synonym: "yEIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2-alpha (yeast)" EXACT [UniProtKB:P20459]
xref: UniProtKB:P20459
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template SGD:S000003767 ! SUI2 (yeast)

[Term]
id: PR:P68101
name: eukaryotic translation initiation factor 2 subunit 1 (rat)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of rat." [OMA:P68101, PANTHER:PTHR10602:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Eif2a" RELATED Gene-based [UniProtKB:P68101]
synonym: "Eif2s1" RELATED Gene-based [UniProtKB:P68101]
synonym: "rEIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2A (rat)" EXACT [UniProtKB:P68101]
synonym: "eIF-2alpha (rat)" EXACT [UniProtKB:P68101]
synonym: "eIF-2-alpha (rat)" EXACT [UniProtKB:P68101]
synonym: "eukaryotic translation initiation factor 2 subunit alpha (rat)" EXACT [UniProtKB:P68101]
xref: UniProtKB:P68101
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template RGD:620963 ! Eif2s1 (rat)

[Term]
id: PR:Q6ZWX6
name: eukaryotic translation initiation factor 2 subunit 1 (mouse)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of mouse." [OMA:Q6ZWX6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Eif2a" RELATED Gene-based [UniProtKB:Q6ZWX6]
synonym: "Eif2s1" RELATED Gene-based [UniProtKB:Q6ZWX6]
synonym: "mEIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2A (mouse)" RELATED [UniProtKB:Q6ZWX6]
synonym: "eIF-2alpha (mouse)" EXACT [UniProtKB:Q6ZWX6]
synonym: "eIF-2-alpha (mouse)" EXACT [UniProtKB:Q6ZWX6]
synonym: "eukaryotic translation initiation factor 2 subunit alpha (mouse)" EXACT [UniProtKB:Q6ZWX6]
xref: UniProtKB:Q6ZWX6
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template MGI:95299 ! Eif2s1 (mouse)

[Term]
id: PR:P56286
name: eukaryotic translation initiation factor 2 subunit alpha (Schizosaccharomyces pombe 972h-)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:P56286, PRO:DNx]
comment: Category=organism-gene.
synonym: "tif211" RELATED Gene-based [UniProtKB:P56286]
synonym: "SPAC3G9.09c" RELATED Gene-based [UniProtKB:P56286]
synonym: "Spom972h-EIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2-alpha (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:P56286]
xref: UniProtKB:P56286
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template PomBase:SPAC3G9.09c ! tif211 (Schizosaccharomyces pombe)

[Term]
id: PR:P05198
name: eukaryotic translation initiation factor 2 subunit 1 (human)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P05198]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "EIF2A" RELATED Gene-based [UniProtKB:P05198]
synonym: "EIF2S1" RELATED Gene-based [UniProtKB:P05198]
synonym: "hEIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2A (human)" BROAD [UniProtKB:P05198]
synonym: "eIF-2alpha (human)" EXACT [UniProtKB:P05198]
synonym: "eIF-2-alpha (human)" EXACT [UniProtKB:P05198]
synonym: "eukaryotic translation initiation factor 2 subunit alpha (human)" EXACT [UniProtKB:P05198]
xref: UniProtKB:P05198
xref: Reactome:R-HSA-72510 "PR:P05198 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template HGNC:3265 ! EIF2S1 (human)

[Term]
id: PR:000050560
name: eukaryotic translation initiation factor 2 subunit alpha (Schizosaccharomyces pombe)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of Schizosaccharomyces pombe." [PRO:DAN]
comment: Category=organism-gene.
synonym: "tif211" RELATED Gene-based [UniProtKB:P56286]
synonym: "SPAC3G9.09c" RELATED Gene-based [UniProtKB:P56286]
synonym: "Spom-EIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2-alpha (Schizosaccharomyces pombe)" EXACT [UniProtKB:P56286]
intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template PomBase:SPAC3G9.09c ! tif211 (Schizosaccharomyces pombe)

[Term]
id: PR:Q5ZLX2
name: eukaryotic translation initiation factor 2 subunit 1 (chicken)
def: "A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of chicken." [OMA:Q5ZLX2, PANTHER:PTHR10602:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "EIF2A" RELATED Gene-based [UniProtKB:Q5ZLX2]
synonym: "EIF2S1" RELATED Gene-based [UniProtKB:Q5ZLX2]
synonym: "RCJMB04_4i21" RELATED Gene-based [UniProtKB:Q5ZLX2]
synonym: "chick-EIF2S1" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2A (chicken)" RELATED [UniProtKB:Q5ZLX2]
synonym: "eIF-2alpha (chicken)" EXACT [UniProtKB:Q5ZLX2]
synonym: "eIF-2-alpha (chicken)" EXACT [UniProtKB:Q5ZLX2]
synonym: "eukaryotic translation initiation factor 2 subunit alpha (chicken)" EXACT [UniProtKB:Q5ZLX2]
xref: UniProtKB:Q5ZLX2
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000006971 ! eukaryotic translation initiation factor 2 subunit 1
relationship: has_gene_template NCBIGene:423279 ! EIF2S1 (chicken)