[Term]
id: PR:P00374-2
name: dihydrofolate reductase isoform h2 (human)
def: "A dihydrofolate reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00374-2." [PRO:DNx, UniProtKB:P00374]
comment: Category=organism-sequence.
synonym: "hDHFR/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00374-2
is_a: PR:P00374 ! dihydrofolate reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00375
name: dihydrofolate reductase (mouse)
def: "A dihydrofolate reductase that is encoded in the genome of mouse." [PRO:DAN]
comment: Category=organism-gene.
synonym: "Dhfr" RELATED Gene-based [UniProtKB:P00375]
synonym: "mDHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00375
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000006844 ! dihydrofolate reductase
relationship: has_gene_template MGI:94890 ! Dhfr (mouse)

[Term]
id: PR:P00374-1
name: dihydrofolate reductase isoform 1 (human)
def: "A dihydrofolate reductase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hDHFR/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00374-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038600 ! dihydrofolate reductase isoform 1

[Term]
id: PR:Q93341
name: putative dihydrofolate reductase (worm)
def: "A dihydrofolate reductase that is encoded in the genome of worm." [PRO:DAN]
comment: Category=organism-gene.
synonym: "dhfr-1" RELATED Gene-based [UniProtKB:Q93341]
synonym: "C36B1.7" RELATED Gene-based [UniProtKB:Q93341]
synonym: "DHFR (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q93341
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000006844 ! dihydrofolate reductase
relationship: has_gene_template WormBase:WBGene00007974 ! dhfr-1 (worm)

[Term]
id: PR:Q920D2
name: dihydrofolate reductase (rat)
def: "A dihydrofolate reductase that is encoded in the genome of rat." [PRO:DAN]
comment: Category=organism-gene.
synonym: "Dhfr" RELATED Gene-based [UniProtKB:Q920D2]
synonym: "rDHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q920D2
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000006844 ! dihydrofolate reductase
relationship: has_gene_template RGD:2500 ! Dhfr (rat)

[Term]
id: PR:000019669
name: dihydrofolate reductase, initiator methionine removed form
def: "A dihydrofolate reductase that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "DHFR/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000006844 ! dihydrofolate reductase
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P17719
name: dihydrofolate reductase (fruit fly)
def: "A dihydrofolate reductase that is encoded in the genome of fruit fly." [PRO:DAN]
comment: Category=organism-gene.
synonym: "Dhfr" RELATED Gene-based [UniProtKB:P17719]
synonym: "CG14887" RELATED Gene-based [UniProtKB:P17719]
synonym: "fly-DHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P17719
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000006844 ! dihydrofolate reductase
relationship: has_gene_template FlyBase:FBgn0004087 ! Dhfr (fruit fly)

[Term]
id: PR:P00378
name: dihydrofolate reductase (chicken)
def: "A dihydrofolate reductase that is encoded in the genome of chicken." [PRO:DAN]
comment: Category=organism-gene.
synonym: "DHFR" RELATED Gene-based [UniProtKB:P00378]
synonym: "chick-DHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00378
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000006844 ! dihydrofolate reductase

[Term]
id: PR:P00374
name: dihydrofolate reductase (human)
def: "A dihydrofolate reductase that is encoded in the genome of human." [PRO:DAN, UniProtKB:P00374]
comment: Category=organism-gene.
synonym: "DHFR" RELATED Gene-based [UniProtKB:P00374]
synonym: "hDHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00374
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006844 ! dihydrofolate reductase
relationship: has_gene_template HGNC:2861 ! DHFR (human)

[Term]
id: PR:000038600
name: dihydrofolate reductase isoform 1
def: "A dihydrofolate reductase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00374-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "DHFR/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000006844 ! dihydrofolate reductase

[Term]
id: PR:P07807
name: dihydrofolate reductase (yeast)
def: "A dihydrofolate reductase that is encoded in the genome of yeast." [OMA:P07807, PRO:DNx]
comment: Category=organism-gene.
synonym: "DFR1" RELATED Gene-based [UniProtKB:P07807]
synonym: "O5231" RELATED Gene-based [UniProtKB:P07807]
synonym: "yDHFR" EXACT PRO-short-label [PRO:DNx]
synonym: "YOR236W" RELATED Gene-based [UniProtKB:P07807]
xref: UniProtKB:P07807
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000006844 ! dihydrofolate reductase
relationship: has_gene_template SGD:S000005762 ! DFR1 (yeast)

[Term]
id: PR:000006844
name: dihydrofolate reductase
def: "A protein that is a translation product of the human DHFR gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "DHFR" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2603
is_a: PR:000000001 ! protein

[Term]
id: PR:Q920D2-1
name: dihydrofolate reductase isoform 1 (rat)
def: "A dihydrofolate reductase isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rDHFR/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q920D2-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038600 ! dihydrofolate reductase isoform 1

[Term]
id: PR:P00375-1
name: dihydrofolate reductase isoform 1 (mouse)
def: "A dihydrofolate reductase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mDHFR/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00375-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038600 ! dihydrofolate reductase isoform 1

[Term]
id: PR:000047172
name: dihydrofolate reductase, initiator methionine removed form (human)
def: "A dihydrofolate reductase (human) that has had the initiator methionine removed. UniProtKB:P00374, 2-187." [PRO:DNx, Reactome:R-HSA-197984, Reactome:R-HSA-54049]
comment: Category=organism-modification.
synonym: "PRO_0000186362" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hDHFR/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00374, 2-187" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-54049 "PR:000047172 located_in GO:0005654"
xref: Reactome:R-HSA-197984 "PR:000047172 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P00374 ! dihydrofolate reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens