[Term]
id: PR:P00374-2
name: dihydrofolate reductase isoform h2 (human)
def: "A dihydrofolate reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00374-2." [PRO:DNx, UniProtKB:P00374]
comment: Category=organism-sequence.
synonym: "hDHFR/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00374-2
is_a: PR:P00374 ! dihydrofolate reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000006844
name: dihydrofolate reductase
def: "A protein that is a translation product of the human DHFR gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "DHFR" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2603
is_a: PR:000000001 ! protein

[Term]
id: PR:P00374
name: dihydrofolate reductase (human)
def: "A dihydrofolate reductase that is encoded in the genome of human." [PRO:DAN, UniProtKB:P00374]
comment: Category=organism-gene.
synonym: "DHFR" RELATED Gene-based [UniProtKB:P00374]
synonym: "hDHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00374
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006844 ! dihydrofolate reductase
relationship: has_gene_template HGNC:2861 ! DHFR (human)

[Term]
id: PR:P00374-1
name: dihydrofolate reductase isoform 1 (human)
def: "A dihydrofolate reductase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hDHFR/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00374-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038600 ! dihydrofolate reductase isoform 1

[Term]
id: PR:000047172
name: dihydrofolate reductase, initiator methionine removed form (human)
def: "A dihydrofolate reductase (human) that has had the initiator methionine removed. UniProtKB:P00374, 2-187." [PRO:DNx, Reactome:R-HSA-197984, Reactome:R-HSA-54049]
comment: Category=organism-modification.
synonym: "PRO_0000186362" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hDHFR/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00374, 2-187" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-54049 "PR:000047172 located_in GO:0005654"
xref: Reactome:R-HSA-197984 "PR:000047172 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P00374 ! dihydrofolate reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens