[Term]
id: PR:Q8TEK3
name: histone-lysine N-methyltransferase, H3 lysine-79 specific (human)
def: "A histone-lysine N-methyltransferase, H3 lysine-79 specific that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8TEK3]
comment: Category=organism-gene.
synonym: "KMT4" RELATED Gene-based [UniProtKB:Q8TEK3]
synonym: "DOT1L" RELATED Gene-based [UniProtKB:Q8TEK3]
synonym: "hDOT1L" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1814" RELATED Gene-based [UniProtKB:Q8TEK3]
synonym: "H3-K79-HMTase (human)" EXACT [UniProtKB:Q8TEK3]
synonym: "DOT1-like protein (human)" EXACT [UniProtKB:Q8TEK3]
synonym: "lysine N-methyltransferase 4 (human)" EXACT [UniProtKB:Q8TEK3]
synonym: "histone H3-K79 methyltransferase (human)" EXACT [UniProtKB:Q8TEK3]
xref: UniProtKB:Q8TEK3
xref: Reactome:R-HSA-3239030 "PR:Q8TEK3 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006642 ! histone-lysine N-methyltransferase, H3 lysine-79 specific
relationship: has_gene_template HGNC:24948 ! DOT1L (human)

[Term]
id: PR:000006642
name: histone-lysine N-methyltransferase, H3 lysine-79 specific
def: "A protein that is a translation product of the human DOT1L gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "KMT4" RELATED Gene-based []
synonym: "DOT1L" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1814" RELATED Gene-based []
synonym: "H3-K79-HMTase" EXACT []
synonym: "DOT1-like protein" EXACT []
synonym: "lysine N-methyltransferase 4" EXACT []
synonym: "histone H3-K79 methyltransferase" EXACT []
xref: IUPHARobj:2650
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8TEK3-1
name: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform h2 (human)
def: "A histone-lysine N-methyltransferase, H3 lysine-79 specific (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TEK3-1." [PRO:DNx, UniProtKB:Q8TEK3]
comment: Category=organism-sequence.
synonym: "hDOT1L/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8TEK3-1
is_a: PR:Q8TEK3 ! histone-lysine N-methyltransferase, H3 lysine-79 specific (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8TEK3-2
name: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform h1 (human)
def: "A histone-lysine N-methyltransferase, H3 lysine-79 specific (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TEK3-2." [PRO:DNx, UniProtKB:Q8TEK3]
comment: Category=organism-sequence.
synonym: "hDOT1L/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8TEK3-2
is_a: PR:Q8TEK3 ! histone-lysine N-methyltransferase, H3 lysine-79 specific (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens