[Term]
id: PR:000037506
name: DNA (cytosine-5)-methyltransferase 1 phosphorylated 2 (human)
def: "A DNA (cytosine-5)-methyltransferase 1 (human) that is phosphorylated on Ser residues equivalent to Ser-127 and Ser-143 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Ser-127/Ser-143, MOD:00046." [PMID:20613874, PRO:KER]
comment: Category=organism-modification. Kinase=("AKT"; PR:000029189; Ser-127/Ser-143). Kinase=("PKC"; PR:000003057; Ser-127).
synonym: "hDNMT1/Phos:2" EXACT PRO-short-label [PRO:DAN]
synonym: "pDnmt1S127/S143" EXACT [PMID:20613874]
synonym: "UniProtKB:P26358-1, Ser-127/Ser-143, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P26358 ! DNA (cytosine-5)-methyltransferase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000037505
name: DNA (cytosine-5)-methyltransferase 1 phosphorylated 1 (human)
def: "A DNA (cytosine-5)-methyltransferase 1 (human) that is phosphorylated on a residue equivalent to Ser-127 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Ser-127, MOD:00046." [PMID:20613874, PRO:KER]
comment: Category=organism-modification. Kinase=("AKT"; PR:000029189; Ser-127). Kinase=("PKC"; PR:000003057; Ser-127).
synonym: "pDnmt1S127" EXACT [PMID:20613874]
synonym: "hDNMT1/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P26358-1, Ser-127, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P26358 ! DNA (cytosine-5)-methyltransferase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000037504
name: DNA (cytosine-5)-methyltransferase 1 unphosphorylated 1 (human)
def: "A DNA (cytosine-5)-methyltransferase 1 (human) that lacks phosphorylated residues at positions equivalent to Ser-127 and Ser-143 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Ser-127/Ser-143, PR:000026291." [PMID:20613874, PRO:KER]
comment: Category=organism-modification.
synonym: "hDNMT1/UnPhos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P26358-1, Ser-127/Ser-143, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P26358 ! DNA (cytosine-5)-methyltransferase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P26358-1
name: DNA (cytosine-5)-methyltransferase 1 isoform 1 (human)
def: "A DNA (cytosine-5)-methyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26358-1." [PRO:DNx, UniProtKB:P26358]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hDNMT1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P26358-1
is_a: PR:P26358 ! DNA (cytosine-5)-methyltransferase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P26358-2
name: DNA (cytosine-5)-methyltransferase 1 isoform h2 (human)
def: "A DNA (cytosine-5)-methyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26358-2." [PRO:DNx, UniProtKB:P26358]
comment: Category=organism-sequence.
synonym: "hDNMT1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA (cytosine-5)-methyltransferase 1 isoform Dnmt1b (human)" EXACT [UniProtKB:P26358]
xref: UniProtKB:P26358-2
is_a: PR:P26358 ! DNA (cytosine-5)-methyltransferase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P26358
name: DNA (cytosine-5)-methyltransferase 1 (human)
def: "A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P26358]
comment: Category=organism-gene.
synonym: "AIM" RELATED Gene-based [UniProtKB:P26358]
synonym: "DNMT" RELATED Gene-based [UniProtKB:P26358]
synonym: "CXXC9" RELATED Gene-based [UniProtKB:P26358]
synonym: "DNMT1" RELATED Gene-based [UniProtKB:P26358]
synonym: "hDNMT1" EXACT PRO-short-label [PRO:DNx]
synonym: "MCMT (human)" EXACT [UniProtKB:P26358]
synonym: "Dnmt1 (human)" EXACT [UniProtKB:P26358]
synonym: "M.HsaI (human)" EXACT [UniProtKB:P26358]
synonym: "DNA MTase HsaI (human)" EXACT [UniProtKB:P26358]
synonym: "DNA methyltransferase HsaI (human)" EXACT [UniProtKB:P26358]
synonym: "CXXC-type zinc finger protein 9 (human)" EXACT [UniProtKB:P26358]
xref: Reactome:R-HSA-212181 "PR:P26358 located_in GO:0005654"
xref: UniProtKB:P26358
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006606 ! DNA (cytosine-5)-methyltransferase 1
relationship: has_gene_template HGNC:2976 ! DNMT1 (human)

[Term]
id: PR:P26358-3
name: DNA (cytosine-5)-methyltransferase 1 isoform h3 (human)
def: "A DNA (cytosine-5)-methyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26358-3." [PRO:DNx, UniProtKB:P26358]
comment: Category=organism-sequence.
synonym: "hDNMT1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P26358-3
is_a: PR:P26358 ! DNA (cytosine-5)-methyltransferase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000006606
name: DNA (cytosine-5)-methyltransferase 1
def: "A protein that is a translation product of the human DNMT1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "AIM" RELATED Gene-based []
synonym: "Uim" RELATED Gene-based []
synonym: "DNMT" RELATED Gene-based []
synonym: "MCMT" EXACT []
synonym: "Met1" RELATED Gene-based []
synonym: "CXXC9" RELATED Gene-based []
synonym: "DNMT1" EXACT PRO-short-label [PRO:DNx]
synonym: "Dnmt1" EXACT []
synonym: "met-1" EXACT []
synonym: "M.HsaI" EXACT []
synonym: "M.MmuI" EXACT []
synonym: "DNA MTase HsaI" EXACT []
synonym: "DNA MTase MmuI" EXACT []
synonym: "DNA methyltransferase HsaI" EXACT []
synonym: "DNA methyltransferase MmuI" EXACT []
synonym: "CXXC-type zinc finger protein 9" EXACT []
xref: IUPHARobj:2605
is_a: PR:000000001 ! protein