[Term]
id: PR:000006596
name: deoxyribonuclease-2-alpha
def: "A protein that is a translation product of the human DNASE2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "DNL2" RELATED Gene-based []
synonym: "DNASE2" EXACT PRO-short-label [PRO:DNx]
synonym: "DNASE2A" RELATED Gene-based []
synonym: "R31240_2" EXACT []
synonym: "acid DNase" EXACT []
synonym: "DNase II alpha" EXACT []
synonym: "lysosomal DNase II" EXACT []
synonym: "deoxyribonuclease II alpha" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:O00115-1
name: deoxyribonuclease-2-alpha isoform h1 (human)
def: "A deoxyribonuclease-2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00115-1." [PRO:DNx, UniProtKB:O00115]
comment: Category=organism-sequence.
synonym: "hDNASE2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00115-1
is_a: PR:O00115 ! deoxyribonuclease-2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00115-2
name: deoxyribonuclease-2-alpha isoform h2 (human)
def: "A deoxyribonuclease-2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00115-2." [PRO:DNx, UniProtKB:O00115]
comment: Category=organism-sequence.
synonym: "hDNASE2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00115-2
is_a: PR:O00115 ! deoxyribonuclease-2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047201
name: deoxyribonuclease-2-alpha, signal peptide removed form (human)
def: "A deoxyribonuclease-2-alpha (human) that has had the signal peptide removed. UniProtKB:O00115, 19-360." [PRO:DNx, Reactome:R-HSA-429822, Reactome:R-HSA-434322]
comment: Category=organism-modification.
synonym: "PRO_0000007291" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hDNASE2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00115, 19-360" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-429822 "PR:000047201 located_in GO:0043202"
xref: Reactome:R-HSA-434322 "PR:000047201 located_in GO:0005796"
intersection_of: PR:O00115 ! deoxyribonuclease-2-alpha (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00115
name: deoxyribonuclease-2-alpha (human)
def: "A deoxyribonuclease-2-alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:O00115]
comment: Category=organism-gene.
synonym: "DNL2" RELATED Gene-based [UniProtKB:O00115]
synonym: "DNASE2" RELATED Gene-based [UniProtKB:O00115]
synonym: "DNASE2A" RELATED Gene-based [UniProtKB:O00115]
synonym: "hDNASE2" EXACT PRO-short-label [PRO:DNx]
synonym: "R31240_2 (human)" EXACT [UniProtKB:O00115]
synonym: "acid DNase (human)" EXACT [UniProtKB:O00115]
synonym: "DNase II alpha (human)" EXACT [UniProtKB:O00115]
synonym: "lysosomal DNase II (human)" EXACT [UniProtKB:O00115]
synonym: "deoxyribonuclease II alpha (human)" EXACT [UniProtKB:O00115]
xref: UniProtKB:O00115
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006596 ! deoxyribonuclease-2-alpha
relationship: has_gene_template HGNC:2960 ! DNASE2 (human)