[Term]
id: PR:000047181
name: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, transit peptide removed form (human)
def: "A dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P10515, 87-647." [PRO:DNx, Reactome:R-HSA-6792585]
comment: Category=organism-modification.
synonym: "PRO_0000020479" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hDLAT/TransPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10515, 87-647" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6792585 "PR:000047181 located_in GO:0005759"
intersection_of: PR:P10515 ! dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (human)
intersection_of: lacks_part SO:0000725 ! transit_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047182
name: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, transit peptide removed lipoylated 1 (human)
def: "A dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (human) that has had the transit peptide removed and has been post-translationally modified to include lipoylated lysine at positions 132 and 259 of the amino acid sequence represented by UniProtKB:P10515. UniProtKB:P10515, 87-647, Lys-132/Lys-259, MOD:00127." [PRO:DNx, Reactome:R-HSA-69969]
comment: Category=organism-modification.
synonym: "hDLAT/TransPep-/Lipo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000020479, Lys-132/Lys-259, MOD:00127" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P10515, 87-647, Lys-132/Lys-259, MOD:00127" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-69969 "PR:000047182 located_in GO:0005759"
is_a: PR:P10515 ! dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (human)
relationship: has_part MOD:00127 ! N6-lipoyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000725 ! transit_peptide

[Term]
id: PR:000006504
name: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
def: "A protein that is a translation product of the human DLAT gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PBC" EXACT []
synonym: "DLAT" EXACT PRO-short-label [PRO:DNx]
synonym: "DLTA" RELATED Gene-based []
synonym: "PDCE2" EXACT []
synonym: "PDC-E2" EXACT []
synonym: "M2 antigen complex 70 kDa subunit" EXACT []
synonym: "pyruvate dehydrogenase complex component E2" EXACT []
synonym: "70 kDa mitochondrial autoantigen of primary biliary cirrhosis" EXACT []
synonym: "dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex" BROAD [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:P10515
name: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (human)
def: "A dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P10515]
comment: Category=organism-gene.
synonym: "DLAT" RELATED Gene-based [UniProtKB:P10515]
synonym: "DLTA" RELATED Gene-based [UniProtKB:P10515]
synonym: "hDLAT" EXACT PRO-short-label [PRO:DNx]
synonym: "PBC (human)" EXACT [UniProtKB:P10515]
synonym: "PDCE2 (human)" EXACT [UniProtKB:P10515]
synonym: "PDC-E2 (human)" EXACT [UniProtKB:P10515]
synonym: "M2 antigen complex 70 kDa subunit (human)" EXACT [UniProtKB:P10515]
synonym: "pyruvate dehydrogenase complex component E2 (human)" EXACT [UniProtKB:P10515]
synonym: "70 kDa mitochondrial autoantigen of primary biliary cirrhosis (human)" EXACT [UniProtKB:P10515]
synonym: "dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (human)" EXACT [UniProtKB:P10515]
xref: UniProtKB:P10515
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006504 ! dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
relationship: has_gene_template HGNC:2896 ! DLAT (human)