[Term]
id: PR:000019642
name: dystroglycan 1 proteolytic cleavage product
def: "A dystroglycan 1 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "DAG1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000006267 ! dystroglycan 1

[Term]
id: PR:000037406
name: dystroglycan 1 beta chain (mouse)
def: "A dystroglycan 1 precursor (mouse) that is the C-terminal product of autolytic cleavage. UniProtKB:Q62165, 652-893." [PMID:8872465, PRO:KRC, UniProtKB:Q62165]
comment: Category=organism-modification. Note: Numerical positions start and end of beta chain from UniProt record. PMID:8872465 shows cloning and sequencing of a cDNA containing the the 3'end of the complete cDNA containing the complete beta chain sequence and the 3'-UTR. PMID:9524190 shows immunoblotting with antibody raised against beta-dystroglycan detects a 43-kDa band for beta-dystroglycan in multiple adult tissues (all tissues examined).
synonym: "PRO_0000021068" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "mDAG1/Clv:beta" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-DG (mouse)" EXACT [PRO:DAN]
synonym: "beta-dystroglycan" RELATED []
synonym: "UniProtKB:Q62165, 652-893" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000037404 ! dystroglycan 1 precursor (mouse)
relationship: output_of GO:0016485 ! protein processing
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000037404
name: dystroglycan 1 precursor (mouse)
def: "A dystroglycan 1 (mouse) that has not been subject to autocatalytic cleavage. UniProtKB:Q62165, 28-893." [PMID:8872465, PMID:9057818, PRO:DAN, PRO:KRC]
comment: Category=organism-modification. Note: Presumed direct precursor is the signal peptide removed form. PMID:9057818 shows cloning and sequencing of a cDNA that contains the entire sequence of the alpha-dystroglycan chain. PMID:8872465 shows cloning and sequencing of a cDNA that encodes the 3' end of the full cDNA including the complete sequence of the beta chain and the 3'-UTR.
synonym: "DG precursor" RELATED []
synonym: "mDAG1/precursor" EXACT PRO-short-label [PRO:DNx]
synonym: "dystroglycan precursor" RELATED []
synonym: "dystroglycan propeptide" RELATED [PMID:10683445]
synonym: "UniProtKB:Q62165, 28-893" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q62165 ! dystroglycan 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000037405
name: dystroglycan 1 alpha chain (mouse)
def: "A dystroglycan 1 precursor (mouse) that is the N-terminal product of autolytic cleavage. UniProtKB:Q62165, 28-651." [PMID:9057818, PRO:KRC, UniProtKB:Q62165]
comment: Category=organism-modification. Note: Numerical positions start and end of alpha chain from UniProt record. PMID:9057818 shows cloning and sequencing of a cDNA that contains the entire alpha-dystroglycan sequence.
synonym: "PRO_0000021067" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "mDAG1/Clv:alpha" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-DG (mouse)" EXACT [PRO:DAN]
synonym: "alpha-dystroglycan" RELATED []
synonym: "UniProtKB:Q62165, 28-651" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000037404 ! dystroglycan 1 precursor (mouse)
relationship: output_of GO:0016485 ! protein processing
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q14118
name: dystroglycan 1 (human)
def: "A dystroglycan 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14118]
comment: Category=organism-gene.
synonym: "DAG1" RELATED Gene-based [UniProtKB:Q14118]
synonym: "hDAG1" EXACT PRO-short-label [PRO:DNx]
synonym: "dystroglycan (human)" EXACT [UniProtKB:Q14118]
synonym: "dystrophin-associated glycoprotein 1 (human)" EXACT [UniProtKB:Q14118]
xref: UniProtKB:Q14118
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006267 ! dystroglycan 1
relationship: has_gene_template HGNC:2666 ! DAG1 (human)

[Term]
id: PR:Q62165
name: dystroglycan 1 (mouse)
def: "A dystroglycan 1 that is encoded in the genome of mouse." [OMA:Q62165, PRO:DNx]
comment: Category=organism-gene.
synonym: "Dag1" RELATED Gene-based [UniProtKB:Q62165]
synonym: "mDAG1" EXACT PRO-short-label [PRO:DNx]
synonym: "dystroglycan (mouse)" EXACT [UniProtKB:Q62165]
synonym: "dystrophin-associated glycoprotein 1 (mouse)" EXACT [UniProtKB:Q62165]
xref: UniProtKB:Q62165
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000006267 ! dystroglycan 1
relationship: has_gene_template MGI:101864 ! Dag1 (mouse)

[Term]
id: PR:000057118
name: dystroglycan 1 O-glycosylated 2 (human)
def: "A dystroglycan 1 (human) that has been O-glycosylated at the residue equivalent to Thr-63 of the amino acid sequence represented by UniProtKB:Q14118-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q14118-1, Thr-63, MOD:00005~GNO:G29068FM." [GlyGen:Q14118-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hDAG1/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14118-1, Thr-63, MOD:00005~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q14118 ! dystroglycan 1 (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057119
name: dystroglycan 1 O-glycosylated 3 (human)
def: "A dystroglycan 1 (human) that has been O-glycosylated at the residue equivalent to Thr-63 of the amino acid sequence represented by UniProtKB:Q14118-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q14118-1, Thr-63, MOD:00005~GNO:G43417UB." [GlyGen:Q14118-1, PMID:23234360, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hDAG1/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14118-1, Thr-63, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q14118 ! dystroglycan 1 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057116
name: dystroglycan 1 N-glycosylated 1 (human)
def: "A dystroglycan 1 (human) that has been N-glycosylated at the residue equivalent to Asn-661 of the amino acid sequence represented by UniProtKB:Q14118-1, in which the glycan composition is represented by GlyTouCan:G37399XV. Example: UniProtKB:Q14118-1, Asn-661, MOD:00160~GNO:G37399XV." [GlyGen:Q14118-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hDAG1/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14118-1, Asn-661, MOD:00160~GNO:G37399XV" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q14118 ! dystroglycan 1 (human)
relationship: has_part GNO:G37399XV ! G37399XV
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057117
name: dystroglycan 1 O-glycosylated 1 (human)
def: "A dystroglycan 1 (human) that has been O-glycosylated at the residue equivalent to Thr-343 of the amino acid sequence represented by UniProtKB:Q14118-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q14118-1, Thr-343, MOD:00005~GNO:G53434XO." [GlyGen:Q14118-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hDAG1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14118-1, Thr-343, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q14118 ! dystroglycan 1 (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000006267
name: dystroglycan 1
def: "A protein that is a translation product of the human DAG1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "DAG1" EXACT PRO-short-label [PRO:DNx]
synonym: "Dag-1" RELATED Gene-based []
synonym: "dystroglycan" EXACT []
synonym: "dystrophin-associated glycoprotein 1" EXACT []
is_a: PR:000000001 ! protein