[Term]
id: PR:P46108
name: adapter molecule crk (human)
def: "An adapter molecule crk that is encoded in the genome of human." [PRO:DNx, UniProtKB:P46108]
comment: Category=organism-gene.
synonym: "CRK" RELATED Gene-based [UniProtKB:P46108]
synonym: "hCRK" EXACT PRO-short-label [PRO:DNx]
synonym: "p38 (human)" BROAD [UniProtKB:P46108]
synonym: "proto-oncogene c-Crk (human)" EXACT [UniProtKB:P46108]
xref: UniProtKB:P46108
xref: Reactome:R-HSA-2980677 "PR:P46108 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005882 ! adapter molecule crk
relationship: has_gene_template HGNC:2362 ! CRK (human)

[Term]
id: PR:P46108-2
name: adapter molecule crk isoform Crk-I (human)
def: "An adapter molecule crk (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46108-2." [PRO:DNx, UniProtKB:P46108]
comment: Category=organism-sequence.
synonym: "hCRK/iso:Crk-I" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46108-2
is_a: PR:P46108 ! adapter molecule crk (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000005882
name: adapter molecule crk
def: "A protein that is a translation product of the human CRK gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CRK" EXACT PRO-short-label [PRO:DNx]
synonym: "p38" BROAD [PRO:DNx]
synonym: "Crko" RELATED Gene-based []
synonym: "proto-oncogene C-crk" EXACT []
synonym: "proto-oncogene c-Crk" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P46108-1
name: adapter molecule crk isoform Crk-II (human)
def: "An adapter molecule crk isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCRK/iso:Crk-II" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46108-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039485 ! adapter molecule crk isoform 1

[Term]
id: PR:000045789
name: adapter molecule crk phosphorylated 1 (human)
def: "An adapter molecule crk (human) that has been phosphorylated at the position equivalent to Tyr-221 of the amino acid sequence represented by UniProtKB:P46108-1. Example: UniProtKB:P46108-1, Tyr-221, MOD:00048." [PMID:12955086, PMID:9642287, iPTMnet:P46108]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12955086, PMID:9642287). Status=unreviewed.
synonym: "hCRK/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46108-1, Tyr-221, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P46108 ! adapter molecule crk (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens