[Term]
id: PR:000005385
name: cofilin-1
def: "A protein that is a translation product of the human CFL1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CFL" RELATED Gene-based []
synonym: "p18" BROAD [PRO:DNx]
synonym: "CFL1" EXACT PRO-short-label [PRO:DNx]
synonym: "18 kDa phosphoprotein" EXACT []
synonym: "cofilin, non-muscle isoform" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P23528-1
name: cofilin-1 isoform 1 (human)
def: "A cofilin-1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCFL1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23528-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039099 ! cofilin-1 isoform 1

[Term]
id: PR:000046697
name: cofilin-1, initiator methionine removed phosphorylated 1 (human)
def: "A cofilin-1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 3 of the amino acid sequence represented by UniProtKB:P23528. UniProtKB:P23528, 2-166, Ser-3, MOD:00046." [PRO:DNx, Reactome:R-HSA-399813]
comment: Category=organism-modification.
synonym: "hCFL1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000214898, Ser-3, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23528, 2-166, Ser-3, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-399813 "PR:000046697 located_in GO:0005829"
is_a: PR:P23528 ! cofilin-1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000046696
name: cofilin-1, initiator methionine removed form (human)
def: "A cofilin-1 (human) that has had the initiator methionine removed. UniProtKB:P23528, 2-166." [PRO:DNx, Reactome:R-HSA-350747, Reactome:R-HSA-350751]
comment: Category=organism-modification.
synonym: "PRO_0000214898" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hCFL1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P23528, 2-166" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-350747 "PR:000046696 located_in GO:0005576"
xref: Reactome:R-HSA-350751 "PR:000046696 located_in GO:0005829"
xref: TDR:3575
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P23528 ! cofilin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P23528
name: cofilin-1 (human)
def: "A cofilin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P23528]
comment: Category=organism-gene.
synonym: "CFL" RELATED Gene-based [UniProtKB:P23528]
synonym: "CFL1" RELATED Gene-based [UniProtKB:P23528]
synonym: "hCFL1" EXACT PRO-short-label [PRO:DNx]
synonym: "p18 (human)" BROAD [UniProtKB:P23528]
synonym: "18 kDa phosphoprotein (human)" EXACT [UniProtKB:P23528]
synonym: "cofilin, non-muscle isoform (human)" EXACT [UniProtKB:P23528]
xref: UniProtKB:P23528
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005385 ! cofilin-1
relationship: has_gene_template HGNC:1874 ! CFL1 (human)