[Term]
id: PR:Q803H4
name: histone H3-like centromeric protein A (zebrafish)
def: "A histone H3-like centromeric protein A that is encoded in the genome of zebrafish." [PRO:DNx]
comment: Category=organism-gene.
synonym: "cenpa" RELATED Gene-based [UniProtKB:Q803H4]
synonym: "z-CENPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CENP-A (zebrafish)" EXACT [UniProtKB:Q803H4]
synonym: "centromere protein A (zebrafish)" EXACT [UniProtKB:Q803H4]
xref: UniProtKB:Q803H4
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000005323 ! histone H3-like centromeric protein A
relationship: has_gene_template NCBIGene:100302659 ! cenpa (zebrafish)

[Term]
id: PR:Q6XXM1
name: histone H3-like centromeric protein A (chicken)
def: "A histone H3-like centromeric protein A that is encoded in the genome of chicken." [OMA:Q6XXM1, PRO:DNx]
comment: Category=organism-gene.
synonym: "CENPA" RELATED Gene-based [UniProtKB:Q6XXM1]
synonym: "GgCENP-A" EXACT [UniProtKB:Q6XXM1]
synonym: "chick-CENPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CENP-A (chicken)" EXACT [UniProtKB:Q6XXM1]
synonym: "centromere protein A (chicken)" EXACT [UniProtKB:Q6XXM1]
xref: UniProtKB:Q6XXM1
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000005323 ! histone H3-like centromeric protein A
relationship: has_gene_template NCBIGene:100113359 ! CENPA (chicken)

[Term]
id: PR:000035363
name: histone H3-like centromeric protein A, initiator methionine removed phosphorylated 1
def: "A histone H3-like centromeric protein A that has been phosphorylated at the position equivalent to Ser-7 of the amino acid sequence represented by UniProtKB:P49450. Example: UniProtKB:P49450, 2-140, Ser-7, MOD:00046." [PMID:15592459, PRO:DAN, PRO:KER]
comment: Category=modification.
synonym: "CENP-A phosphorylated" EXACT []
synonym: "CENPA/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000005323 ! histone H3-like centromeric protein A
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P49450-2
name: histone H3-like centromeric protein A isoform h2 (human)
def: "A histone H3-like centromeric protein A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49450-2." [PRO:DNx, UniProtKB:P49450]
comment: Category=organism-sequence.
synonym: "hCENPA/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49450-2
is_a: PR:P49450 ! histone H3-like centromeric protein A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O35216
name: histone H3-like centromeric protein A (mouse)
def: "A histone H3-like centromeric protein A that is encoded in the genome of mouse." [OMA:O35216, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cenpa" RELATED Gene-based [UniProtKB:O35216]
synonym: "mCENPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CENP-A (mouse)" EXACT [UniProtKB:O35216]
synonym: "centromere protein A (mouse)" EXACT [UniProtKB:O35216]
xref: UniProtKB:O35216
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000005323 ! histone H3-like centromeric protein A
relationship: has_gene_template MGI:88375 ! Cenpa (mouse)

[Term]
id: PR:000005323
name: histone H3-like centromeric protein A
def: "A core histone that is a translation product of the human CENPA gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CENPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CENP-A" BROAD [PRO:DNx]
synonym: "centromere protein A" BROAD [PRO:DNx]
synonym: "centromere autoantigen A" EXACT []
is_a: PR:000043452 ! core histone

[Term]
id: PR:000045801
name: histone H3-like centromeric protein A phosphorylated 1 (human)
def: "A histone H3-like centromeric protein A (human) that has been phosphorylated at the position equivalent to Ser-68 of the amino acid sequence represented by UniProtKB:P49450-1. Example: UniProtKB:P49450-1, Ser-68, MOD:00046." [PMID:25556658, iPTMnet:P49450]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:25556658). Status=unreviewed.
synonym: "hCENPA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49450-1, Ser-68, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P49450 ! histone H3-like centromeric protein A (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035364
name: histone H3-like centromeric protein A, initiator methionine removed phosphorylated 1 (human)
def: "A histone H3-like centromeric protein A, initiator methionine removed phosphorylated 1 in human. UniProtKB:P49450, 2-140, Ser-7, MOD:00046." [HIstome_var_Hs:Histone_H3-like_centromeric_protein_A, PMID:11756469, PMID:14667408, PMID:15592459, PRO:KER]
comment: Category=organism-modification. Kinase=("AURK"; PR:000035365).
synonym: "hCENPA/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "H3-like_centromeric_protein_A:H3S6ph" BROAD [HIstome_ptm_Hs:H3S6ph]
synonym: "UniProtKB:P49450, 2-140, Ser-7, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035363 ! histone H3-like centromeric protein A, initiator methionine removed phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P49450-1
name: histone H3-like centromeric protein A isoform h1 (human)
def: "A histone H3-like centromeric protein A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49450-1." [PRO:DNx, UniProtKB:P49450]
comment: Category=organism-sequence.
synonym: "hCENPA/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49450-1
is_a: PR:P49450 ! histone H3-like centromeric protein A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49450
name: histone H3-like centromeric protein A (human)
def: "A histone H3-like centromeric protein A that is encoded in the genome of human." [PMID:15592459, PRO:KER]
comment: Category=organism-gene.
synonym: "CENPA" RELATED Gene-based [UniProtKB:P49450]
synonym: "hCENPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CENP-A (human)" EXACT [UniProtKB:P49450]
synonym: "centromere protein A (human)" EXACT [UniProtKB:P49450]
synonym: "centromere autoantigen A (human)" EXACT [UniProtKB:P49450]
xref: Reactome:R-HSA-375317 "PR:P49450 located_in GO:0005829"
xref: Reactome:R-HSA-606322 "PR:P49450 located_in GO:0005654"
xref: UniProtKB:P49450
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005323 ! histone H3-like centromeric protein A
relationship: has_gene_template HGNC:1851 ! CENPA (human)