[Term]
id: PR:000005257
name: cell division protein kinase 4
def: "A CDK2-related kinase that is a translation product of the human CDK4 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CDK4" EXACT PRO-short-label [PRO:DNx]
synonym: "CRK3" EXACT []
synonym: "PSK-J3" EXACT []
synonym: "cyclin-dependent kinase 4" EXACT []
xref: IUPHARobj:1976
is_a: PR:000003270 ! CDK2-related kinase

[Term]
id: PR:000026623
name: cell division protein kinase 4, initiator methionine removed form (human)
def: "A cell division protein kinase 4, initiator methionine removed form in human. Example: UniProtKB:P11802-1, 2-303." [PRO:DNx]
comment: Category=organism-modification.
synonym: "PRO_0000085778" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "hCDK4/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11802-1, 2-303" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-68330 "PR:000026623 located_in GO:0005829"
xref: Reactome:R-HSA-113843 "PR:000026623 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000019288 ! cell division protein kinase 4, initiator methionine removed form

[Term]
id: PR:P11802
name: cyclin-dependent kinase 4 (human)
def: "A cell division protein kinase 4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11802]
comment: Category=organism-gene.
synonym: "CDK4" RELATED Gene-based [UniProtKB:P11802]
synonym: "hCDK4" EXACT PRO-short-label [PRO:DNx]
synonym: "PSK-J3 (human)" EXACT [UniProtKB:P11802]
synonym: "cell division protein kinase 4 (human)" EXACT [UniProtKB:P11802]
xref: DTO:03100070
xref: UniProtKB:P11802
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005257 ! cell division protein kinase 4
relationship: has_gene_template HGNC:1773 ! CDK4 (human)

[Term]
id: PR:P11802-1
name: cyclin-dependent kinase 4 isoform 1 (human)
def: "A cell division protein kinase 4 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCDK4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11802-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038853 ! cell division protein kinase 4 isoform 1

[Term]
id: PR:P11802-2
name: cyclin-dependent kinase 4 isoform h2 (human)
def: "A cyclin-dependent kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11802-2." [PRO:DNx, UniProtKB:P11802]
comment: Category=organism-sequence.
synonym: "hCDK4/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11802-2
is_a: PR:P11802 ! cyclin-dependent kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046675
name: cell division protein kinase 4, initiator methionine removed phosphorylated 2 (human)
def: "A cell division protein kinase 4, initiator methionine removed form (human) that has been post-translationally modified to include phosphothreonine at position 172 of the amino acid sequence represented by UniProtKB:P11802. UniProtKB:P11802, 2-303, Thr-172, MOD:00047." [PRO:DNx, Reactome:R-HSA-113830]
comment: Category=organism-modification.
synonym: "hCDK4/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000085778, Thr-172, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P11802, 2-303, Thr-172, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-113830 "PR:000046675 located_in GO:0005654"
is_a: PR:000026623 ! cell division protein kinase 4, initiator methionine removed form (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045672
name: cyclin-dependent kinase 4 phosphorylated 1 (human)
def: "A cyclin-dependent kinase 4 (human) that has been phosphorylated at the position equivalent to Tyr-17 of the amino acid sequence represented by UniProtKB:P11802-1. Example: UniProtKB:P11802-1, Tyr-17, MOD:00048." [PMID:18479465, iPTMnet:P11802]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18479465). Status=unreviewed.
synonym: "hCDK4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11802-1, Tyr-17, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P11802 ! cyclin-dependent kinase 4 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens