[Term]
id: PR:000027131
name: G1/S-specific cyclin-D1 phosphorylated 1
def: "A G1/S-specific cyclin-D1 that includes phosphorylation at a threonine residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385. Example: UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]
comment: Category=modification.
synonym: "CCND1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000005121 ! G1/S-specific cyclin-D1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P25322
name: G1/S-specific cyclin-D1 (mouse)
def: "A G1/S-specific cyclin-D1 that is encoded in the genome of mouse." [OMA:P25322, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ccnd1" RELATED Gene-based [UniProtKB:P25322]
synonym: "Cyl-1" RELATED Gene-based [UniProtKB:P25322]
synonym: "mCCND1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25322
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000005121 ! G1/S-specific cyclin-D1
relationship: has_gene_template MGI:88313 ! Ccnd1 (mouse)

[Term]
id: PR:000027132
name: G1/S-specific cyclin-D1 phosphorylated 1 (human)
def: "A G1/S-specific cyclin-D1 phosphorylated 1 in human. UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]
comment: Category=organism-modification.
synonym: "hCCND1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-T286-CCND1 (human)" EXACT [Reactome:R-HSA-75811, Reactome:R-HSA-75813]
synonym: "UniProtKB:P24385, Thr-286, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-75811 "PR:000027132 located_in GO:0005654"
xref: Reactome:R-HSA-75813 "PR:000027132 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027131 ! G1/S-specific cyclin-D1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000037512
name: G1/S-specific cyclin-D1 phosphorylated and multi-ubiquitinated 1 (human)
def: "A G1/S-specific cyclin-D1 (human) that has been both phosphorylated at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385 and been multi-ubiquitinated." [PMID:17081987, PMID:17407548, PRO:KER]
comment: Category=organism-modification. UbLigase=("FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex"; PR:000037513). Kinase=("GSK3B"; PR:P49841; Thr-286).
synonym: "hCCND1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "multi-ubiquitinated phospho-(T286) Cyclin D1 (human)" EXACT [Reactome:R-HSA-177997]
xref: Reactome:R-HSA-177997 "PR:000037512 located_in GO:0005829"
is_a: PR:P24385 ! G1/S-specific cyclin-D1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P24385-1
name: G1/S-specific cyclin-D1 isoform 1 (human)
def: "A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCCND1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P24385-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039111 ! G1/S-specific cyclin-D1 isoform 1

[Term]
id: PR:P39948-1
name: G1/S-specific cyclin-D1 isoform 1 (rat)
def: "A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rCCND1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P39948-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039111 ! G1/S-specific cyclin-D1 isoform 1

[Term]
id: PR:000005121
name: G1/S-specific cyclin-D1
def: "A cyclin-D that is a translation product of the human CCND1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "BCL1" RELATED Gene-based []
synonym: "BCL-1" EXACT []
synonym: "CCND1" EXACT PRO-short-label [PRO:DNx]
synonym: "Cyl-1" RELATED Gene-based []
synonym: "PRAD1" RELATED Gene-based []
synonym: "BCL-1 oncogene" EXACT []
synonym: "PRAD1 oncogene" EXACT []
synonym: "B-cell lymphoma 1 protein" EXACT []
is_a: PR:000050022 ! cyclin-D

[Term]
id: PR:P39948
name: G1/S-specific cyclin-D1 (rat)
def: "A G1/S-specific cyclin-D1 that is encoded in the genome of rat." [OMA:P39948, PANTHER:PTHR10177:SF67, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ccnd1" RELATED Gene-based [UniProtKB:P39948]
synonym: "rCCND1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P39948
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000005121 ! G1/S-specific cyclin-D1
relationship: has_gene_template RGD:68384 ! Ccnd1 (rat)

[Term]
id: PR:P25322-1
name: G1/S-specific cyclin-D1 isoform 1 (mouse)
def: "A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mCCND1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25322-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039111 ! G1/S-specific cyclin-D1 isoform 1

[Term]
id: PR:P55169
name: G1/S-specific cyclin-D1 (chicken)
def: "A G1/S-specific cyclin-D1 that is encoded in the genome of chicken." [OMA:P55169, PANTHER:PTHR10177:SF67, PRO:DNx]
comment: Category=organism-gene.
synonym: "CCND1" RELATED Gene-based [UniProtKB:P55169]
synonym: "chick-CCND1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P55169
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000005121 ! G1/S-specific cyclin-D1
relationship: has_gene_template NCBIGene:396341 ! CCND1 (chicken)

[Term]
id: PR:Q90459
name: G1/S-specific cyclin-D1 (zebrafish)
def: "A G1/S-specific cyclin-D1 that is encoded in the genome of zebrafish." [OMA:Q90459, PANTHER:PTHR10177:SF67, PRO:DNx]
comment: Category=organism-gene.
synonym: "ccnd1" RELATED Gene-based [UniProtKB:Q90459]
synonym: "cycd1" RELATED Gene-based [UniProtKB:Q90459]
synonym: "z-CCND1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q90459
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000005121 ! G1/S-specific cyclin-D1
relationship: has_gene_template ZFIN:ZDB-GENE-980526-176 ! ccnd1 (zebrafish)

[Term]
id: PR:000039111
name: G1/S-specific cyclin-D1 isoform 1
def: "A G1/S-specific cyclin-D1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24385-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "CCND1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000005121 ! G1/S-specific cyclin-D1

[Term]
id: PR:P24385
name: G1/S-specific cyclin-D1 (human)
def: "A G1/S-specific cyclin-D1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "BCL1" RELATED Gene-based [UniProtKB:P24385]
synonym: "CCND1" RELATED Gene-based [UniProtKB:P24385]
synonym: "PRAD1" RELATED Gene-based [UniProtKB:P24385]
synonym: "hCCND1" EXACT PRO-short-label [PRO:DNx]
synonym: "BCL-1 (human)" EXACT [UniProtKB:P24385]
synonym: "BCL-1 oncogene (human)" EXACT [UniProtKB:P24385]
synonym: "PRAD1 oncogene (human)" EXACT [UniProtKB:P24385]
synonym: "B-cell lymphoma 1 protein (human)" EXACT [UniProtKB:P24385]
xref: Reactome:R-HSA-68328 "PR:P24385 located_in GO:0005829"
xref: UniProtKB:P24385
xref: Reactome:R-HSA-113832 "PR:P24385 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005121 ! G1/S-specific cyclin-D1
relationship: has_gene_template HGNC:1582 ! CCND1 (human)

[Term]
id: PR:000046156
name: G1/S-specific cyclin-D1 phosphorylated 1 (mouse)
def: "A G1/S-specific cyclin-D1 (mouse) that has been phosphorylated at Thr-286. UniProtKB:P25322, Thr-286, MOD:00047." [PMID:11124803, iPTMnet:P25322]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11124803). Status=unreviewed.
synonym: "mCCND1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25322, Thr-286, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P25322 ! G1/S-specific cyclin-D1 (mouse)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000037511
name: G1/S-specific cyclin-D1 unphosphorylated 1 (human)
def: "A G1/S-specific cyclin-D1 (human) that lacks phosphorylation at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Thr-286, PR:000026291." [PMID:17407548, PRO:KER]
comment: Category=organism-modification.
synonym: "hCCND1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P24385, Thr-286, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P24385 ! G1/S-specific cyclin-D1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens