[Term]
id: PR:000046579
name: cystathionine beta-synthase, initiator methionine removed pyridoxal phosphate lysine 1 (human)
def: "A cystathionine beta-synthase (human) that has had the initiator methionine removed and has been post-translationally modified to include pyridoxal phosphate lysine at position 119 of the amino acid sequence represented by UniProtKB:P35520. UniProtKB:P35520, 2-551, Lys-119, MOD:00128." [PRO:DNx, Reactome:R-HSA-1614563]
comment: Category=organism-modification.
synonym: "hCBS/InitMet-/Pyrdox:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000167133, Lys-119, MOD:00128" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P35520, 2-551, Lys-119, MOD:00128" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1614563 "PR:000046579 located_in GO:0005829"
is_a: PR:P35520 ! cystathionine beta-synthase (human)
relationship: has_part MOD:00128 ! N6-pyridoxal phosphate-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P35520
name: cystathionine beta-synthase (human)
def: "A cystathionine beta-synthase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P35520]
comment: Category=organism-gene.
synonym: "CBS" RELATED Gene-based [UniProtKB:P35520]
synonym: "hCBS" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-thionase (human)" EXACT [UniProtKB:P35520]
synonym: "serine sulfhydrase (human)" EXACT [UniProtKB:P35520]
xref: UniProtKB:P35520
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005081 ! cystathionine beta-synthase
relationship: has_gene_template HGNC:1550 ! CBS (human)

[Term]
id: PR:000005081
name: cystathionine beta-synthase
def: "A protein that is a translation product of the human CBS gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CBS" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-thionase" EXACT []
synonym: "serine sulfhydrase" EXACT []
xref: IUPHARobj:1443
is_a: PR:000000001 ! protein

[Term]
id: PR:P46794
name: cystathionine beta-synthase (Dictyostelium discoideum)
def: "A cystathionine beta-synthase that is encoded in the genome of Dictyostelium discoideum." [OMA:P46794, PANTHER:PTHR10314:SF18, PRO:DNx]
comment: Category=organism-gene.
synonym: "cysB" RELATED Gene-based [UniProtKB:P46794]
synonym: "Dicty-CBS" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0267386" RELATED Gene-based [UniProtKB:P46794]
synonym: "beta-thionase (Dictyostelium discoideum)" EXACT [UniProtKB:P46794]
synonym: "serine sulfhydrase (Dictyostelium discoideum)" EXACT [UniProtKB:P46794]
xref: UniProtKB:P46794
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000005081 ! cystathionine beta-synthase
relationship: has_gene_template dictyBase:DDB_G0267386 ! cysB (Dictyostelium discoideum)

[Term]
id: PR:Q91WT9-1
name: cystathionine beta-synthase isoform 1 (mouse)
def: "A cystathionine beta-synthase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mCBS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q91WT9-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000042247 ! cystathionine beta-synthase isoform 1

[Term]
id: PR:Q91WT9
name: cystathionine beta-synthase (mouse)
def: "A cystathionine beta-synthase that is encoded in the genome of mouse." [OMA:Q91WT9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cbs" RELATED Gene-based [UniProtKB:Q91WT9]
synonym: "mCBS" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-thionase (mouse)" EXACT [UniProtKB:Q91WT9]
synonym: "serine sulfhydrase (mouse)" EXACT [UniProtKB:Q91WT9]
xref: UniProtKB:Q91WT9
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000005081 ! cystathionine beta-synthase
relationship: has_gene_template MGI:88285 ! Cbs (mouse)

[Term]
id: PR:P32582
name: cystathionine beta-synthase (yeast)
def: "A cystathionine beta-synthase that is encoded in the genome of yeast." [PANTHER:PTHR10314:SF18, PRO:DAN]
comment: Category=organism-gene.
synonym: "CYS4" RELATED Gene-based [UniProtKB:P32582]
synonym: "STR4" RELATED Gene-based [UniProtKB:P32582]
synonym: "yCBS" EXACT PRO-short-label [PRO:DNx]
synonym: "G6667" RELATED Gene-based [UniProtKB:P32582]
synonym: "YGR155W" RELATED Gene-based [UniProtKB:P32582]
synonym: "beta-thionase (yeast)" EXACT [UniProtKB:P32582]
synonym: "serine sulfhydrase (yeast)" EXACT [UniProtKB:P32582]
synonym: "sulfur transfer protein 4 (yeast)" EXACT [UniProtKB:P32582]
xref: UniProtKB:P32582
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000005081 ! cystathionine beta-synthase
relationship: has_gene_template SGD:S000003387 ! CYS4 (yeast)

[Term]
id: PR:000056394
name: cystathionine beta-synthase O-glycosylated 1 (human)
def: "A cystathionine beta-synthase (human) that has been O-glycosylated at the residue equivalent to Thr-434 of the amino acid sequence represented by UniProtKB:P35520-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P35520-1, Thr-434, MOD:00005~GNO:G43417UB." [GlyGen:P35520-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCBS/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35520-1, Thr-434, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P35520 ! cystathionine beta-synthase (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P32232-4
name: cystathionine beta-synthase isoform II (rat)
def: "A cystathionine beta-synthase (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32232-4." [PRO:DNx, UniProtKB:P32232]
comment: Category=organism-sequence.
synonym: "rCBS/iso:II" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P32232-4
is_a: PR:P32232 ! cystathionine beta-synthase (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P32232
name: cystathionine beta-synthase (rat)
def: "A cystathionine beta-synthase that is encoded in the genome of rat." [PANTHER:PTHR10314:SF18, PRO:DAN]
comment: Category=organism-gene.
synonym: "Cbs" RELATED Gene-based [UniProtKB:P32232]
synonym: "rCBS" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-thionase (rat)" EXACT [UniProtKB:P32232]
synonym: "hemoprotein H-450 (rat)" EXACT [UniProtKB:P32232]
synonym: "serine sulfhydrase (rat)" EXACT [UniProtKB:P32232]
xref: UniProtKB:P32232
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000005081 ! cystathionine beta-synthase
relationship: has_gene_template RGD:2287 ! Cbs (rat)

[Term]
id: PR:000042247
name: cystathionine beta-synthase isoform 1
def: "A cystathionine beta-synthase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91WT9-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "CBS/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000005081 ! cystathionine beta-synthase

[Term]
id: PR:P32232-1
name: cystathionine beta-synthase isoform I (rat)
def: "A cystathionine beta-synthase isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rCBS/iso:I" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P32232-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000042247 ! cystathionine beta-synthase isoform 1

[Term]
id: PR:P32232-2
name: cystathionine beta-synthase isoform III (rat)
def: "A cystathionine beta-synthase isoform 2 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rCBS/iso:III" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P32232-2
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000042248 ! cystathionine beta-synthase isoform 2

[Term]
id: PR:P32232-3
name: cystathionine beta-synthase isoform IV (rat)
def: "A cystathionine beta-synthase (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32232-3." [PRO:DNx, UniProtKB:P32232]
comment: Category=organism-sequence.
synonym: "rCBS/iso:IV" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P32232-3
is_a: PR:P32232 ! cystathionine beta-synthase (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P35520-2
name: cystathionine beta-synthase isoform h2 (human)
def: "A cystathionine beta-synthase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35520-2." [PRO:DNx, UniProtKB:P35520]
comment: Category=organism-sequence.
synonym: "hCBS/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "cystathionine beta-synthase isoform Minor (human)" EXACT [UniProtKB:P35520]
xref: UniProtKB:P35520-2
is_a: PR:P35520 ! cystathionine beta-synthase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P35520-1
name: cystathionine beta-synthase isoform h1 (human)
def: "A cystathionine beta-synthase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35520-1." [PRO:DNx, UniProtKB:P35520]
comment: Category=organism-sequence.
synonym: "hCBS/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "cystathionine beta-synthase isoform Major (human)" EXACT [UniProtKB:P35520]
xref: UniProtKB:P35520-1
is_a: PR:P35520 ! cystathionine beta-synthase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000042248
name: cystathionine beta-synthase isoform 2
def: "A cystathionine beta-synthase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91WT9-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "CBS/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000005081 ! cystathionine beta-synthase

[Term]
id: PR:Q91WT9-2
name: cystathionine beta-synthase isoform 2 (mouse)
def: "A cystathionine beta-synthase isoform 2 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mCBS/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q91WT9-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000042248 ! cystathionine beta-synthase isoform 2