[Term]
id: PR:O43683
name: mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human." [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER]
comment: Category=organism-gene.
synonym: "BUB1" RELATED Gene-based [UniProtKB:O43683]
synonym: "BUB1L" RELATED Gene-based [UniProtKB:O43683]
synonym: "hBUB1" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1A (human)" EXACT [UniProtKB:O43683]
xref: Reactome:R-HSA-377888 "PR:O43683 located_in GO:0005829"
xref: DTO:03100052
xref: UniProtKB:O43683
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_gene_template HGNC:1148 ! BUB1 (human)

[Term]
id: PR:000035421
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]
comment: Category=organism-modification. Kinase=("ATM"; PR:000035423).
synonym: "hBUB1/Phos:10" EXACT PRO-short-label [PRO:DNx]
synonym: "hBUB1 phosphorylated" RELATED []
synonym: "UniProtKB:O43683-1, Ser-314, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035420 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000035418
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 in human. Phosphorylation of Thr-609 is needed by phosphorylation by Plk1. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:16760428, PRO:KER]
comment: Category=organism-modification. Kinase=("CDK1"; PR:000003271). Kinase=("PLK1"; PR:P53350).
synonym: "hBUB1/Phos:8" EXACT PRO-short-label [PRO:DNx]
synonym: "hBUB1 phosphorylated" RELATED []
synonym: "UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035417 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000035399
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in human." [PMID:10198256, PMID:15525512, PRO:KER]
comment: Category=organism-modification. Kinase=("BUB1"; PR:O43683).
synonym: "hBUB1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "hBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029912 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000004854
name: mitotic checkpoint serine/threonine-protein kinase BUB1
def: "A BUB1/BUB1B protein that is a translation product of the human BUB1 gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA]
comment: Category=gene.
synonym: "BUB1" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1A" EXACT []
synonym: "BUB1L" RELATED Gene-based []
xref: IUPHARobj:1949
is_a: PR:000035665 ! BUB1/BUB1B protein

[Term]
id: PR:O43683-1
name: mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h1 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-1." [PRO:DNx, UniProtKB:O43683]
comment: Category=organism-sequence.
synonym: "hBUB1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43683-1
is_a: PR:O43683 ! mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035412
name: mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)
def: "A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER]
comment: Category=organism-modification. Kinase=("CDK1"; PR:000003271).
synonym: "hBUB1/Phos:7" EXACT PRO-short-label [PRO:JR]
synonym: "UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000035413 ! BUB1 CDK-consensus sites phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43683-3
name: mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h3 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-3." [PRO:DNx, UniProtKB:O43683]
comment: Category=organism-sequence.
synonym: "hBUB1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43683-3
is_a: PR:O43683 ! mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43683-2
name: mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h2 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-2." [PRO:DNx, UniProtKB:O43683]
comment: Category=organism-sequence.
synonym: "hBUB1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43683-2
is_a: PR:O43683 ! mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035405
name: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hBUB1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029916 ! mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form

[Term]
id: PR:000035407
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human." [PMID:11792804, PMID:15525512, PRO:KER]
comment: Category=organism-modification.
synonym: "hBUB1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "hBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035406 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4
relationship: has_part MOD:00696 ! phosphorylated residue