[Term] id: PR:000049803 name: breast cancer type 1 susceptibility protein isoform 1 phosphorylated 2 (human) def: "A breast cancer type 1 susceptibility protein isoform 1 (human) that has been phosphorylated at the position equivalent to Ser-1423. UniProtKB:P38398-1, Ser-1423, MOD:00046." [PMID:15254237, PRO:LN] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15254237). synonym: "hBRCA1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P38398-1, Ser-1423, MOD:00046" EXACT PRO-proteoform-std [PRO:CNA] is_a: PR:P38398-1 ! breast cancer type 1 susceptibility protein isoform 1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P38398 name: breast cancer type 1 susceptibility protein (human) def: "A breast cancer type 1 susceptibility protein that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-gene. synonym: "BRCA1" RELATED Gene-based [UniProtKB:P38398] synonym: "RNF53" RELATED Gene-based [UniProtKB:P38398] synonym: "hBRCA1" EXACT PRO-short-label [PRO:DNx] synonym: "RING finger protein 53 (human)" EXACT [UniProtKB:P38398] synonym: "RING-type E3 ubiquitin transferase BRCA1 (human)" EXACT [UniProtKB:P38398] xref: Reactome:R-HSA-50949 "PR:P38398 located_in GO:0005654" xref: UniProtKB:P38398 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000004803 ! breast cancer type 1 susceptibility protein relationship: has_gene_template HGNC:1100 ! BRCA1 (human) [Term] id: PR:P38398-8 name: breast cancer type 1 susceptibility protein isoform h8 (human) def: "A breast cancer type 1 susceptibility protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P38398-8." [PRO:DNx, UniProtKB:P38398] comment: Category=organism-sequence. synonym: "hBRCA1/iso:h8" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P38398-8 is_a: PR:P38398 ! breast cancer type 1 susceptibility protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P38398-3 name: breast cancer type 1 susceptibility protein isoform 3 (human) def: "A breast cancer type 1 susceptibility protein isoform 3 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hBRCA1/iso:3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P38398-3 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026524 ! breast cancer type 1 susceptibility protein isoform 3 [Term] id: PR:P38398-2 name: breast cancer type 1 susceptibility protein isoform 2 (human) def: "A breast cancer type 1 susceptibility protein isoform 2 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hBRCA1/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P38398-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026522 ! breast cancer type 1 susceptibility protein isoform 2 [Term] id: PR:P38398-1 name: breast cancer type 1 susceptibility protein isoform 1 (human) def: "A breast cancer type 1 susceptibility protein isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hBRCA1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P38398-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026520 ! breast cancer type 1 susceptibility protein isoform 1 [Term] id: PR:P38398-7 name: breast cancer type 1 susceptibility protein isoform h7 (human) def: "A breast cancer type 1 susceptibility protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P38398-7." [PRO:DNx, UniProtKB:P38398] comment: Category=organism-sequence. synonym: "hBRCA1/iso:h7" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P38398-7 is_a: PR:P38398 ! breast cancer type 1 susceptibility protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P38398-6 name: breast cancer type 1 susceptibility protein isoform h6 (human) def: "A breast cancer type 1 susceptibility protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P38398-6." [PRO:DNx, UniProtKB:P38398] comment: Category=organism-sequence. synonym: "hBRCA1/iso:h6" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P38398-6 is_a: PR:P38398 ! breast cancer type 1 susceptibility protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P38398-5 name: breast cancer type 1 susceptibility protein isoform 5 (human) def: "A breast cancer type 1 susceptibility protein isoform 5 that is encoded in the genome of human." [PMID:9528852] comment: Category=organism-sequence. synonym: "hBRCA1/iso:5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P38398-5 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026528 ! breast cancer type 1 susceptibility protein isoform 5 [Term] id: PR:P38398-4 name: breast cancer type 1 susceptibility protein isoform 4 (human) def: "A breast cancer type 1 susceptibility protein isoform 4 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hBRCA1/iso:4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P38398-4 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026526 ! breast cancer type 1 susceptibility protein isoform 4 [Term] id: PR:000026526 name: breast cancer type 1 susceptibility protein isoform 4 def: "A breast cancer type 1 susceptibility protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P38398-4 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "BRCA1/iso:4" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004803 ! breast cancer type 1 susceptibility protein [Term] id: PR:000026524 name: breast cancer type 1 susceptibility protein isoform 3 def: "A breast cancer type 1 susceptibility protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P38398-3 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "BRCA1/iso:3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004803 ! breast cancer type 1 susceptibility protein [Term] id: PR:000026522 name: breast cancer type 1 susceptibility protein isoform 2 def: "A breast cancer type 1 susceptibility protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P38398-2 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "BRCA1/iso:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004803 ! breast cancer type 1 susceptibility protein [Term] id: PR:000026520 name: breast cancer type 1 susceptibility protein isoform 1 def: "A breast cancer type 1 susceptibility protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P38398-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "BRCA1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004803 ! breast cancer type 1 susceptibility protein [Term] id: PR:000026528 name: breast cancer type 1 susceptibility protein isoform 5 def: "A breast cancer type 1 susceptibility protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P38398-5 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "BRCA1/iso:5" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004803 ! breast cancer type 1 susceptibility protein [Term] id: PR:000056425 name: breast cancer type 1 susceptibility protein N-glycosylated 1 (human) def: "A breast cancer type 1 susceptibility protein (human) that has been N-glycosylated at the residue equivalent to Asn-247 of the amino acid sequence represented by UniProtKB:P38398-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P38398-1, Asn-247, MOD:00160~GNO:G00912UN." [GlyGen:P38398-1, PMID:29671580, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hBRCA1/NGlyco:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38398-1, Asn-247, MOD:00160~GNO:G00912UN" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P38398 ! breast cancer type 1 susceptibility protein (human) relationship: has_part GNO:G00912UN ! G00912UN relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046511 name: breast cancer type 1 susceptibility protein phosphorylated 2 (human) def: "A breast cancer type 1 susceptibility protein (human) that has been post-translationally modified to include phosphoserine at positions 1387, 1423, 1457 and 1524 of the amino acid sequence represented by UniProtKB:P38398. UniProtKB:P38398, Ser-1387/Ser-1423/Ser-1457/Ser-1524, MOD:00046." [PRO:DNx, Reactome:R-HSA-75234] comment: Category=organism-modification. synonym: "hBRCA1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38398, Ser-1387/Ser-1423/Ser-1524/Ser-1547, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-75234 "PR:000046511 located_in GO:0005654" is_a: PR:P38398 ! breast cancer type 1 susceptibility protein (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046512 name: breast cancer type 1 susceptibility protein phosphorylated 3 (human) def: "A breast cancer type 1 susceptibility protein (human) that has been post-translationally modified to include phosphoserine at positions 988, 1387, 1423, 1457 and 1524 of the amino acid sequence represented by UniProtKB:P38398. UniProtKB:P38398, Ser-988/Ser-1387/Ser-1423/Ser-1457/Ser-1524, MOD:00046." [PRO:DNx, Reactome:R-HSA-5683800] comment: Category=organism-modification. synonym: "hBRCA1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38398, Ser-988/Ser-1387/Ser-1423/Ser-1457/Ser-1524, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5683800 "PR:000046512 located_in GO:0005654" is_a: PR:P38398 ! breast cancer type 1 susceptibility protein (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046513 name: breast cancer type 1 susceptibility protein sumoylated 1 (human) def: "A breast cancer type 1 susceptibility protein (human) that has been post-translationally modified to include sumoylated lysine at position 109 of the amino acid sequence represented by UniProtKB:P38398. UniProtKB:P38398, Lys-109, MOD:01149." [PRO:DNx, Reactome:R-HSA-2997644] comment: Category=organism-modification. synonym: "hBRCA1/Sumo:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38398, Lys-109, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2997644 "PR:000046513 located_in GO:0005654" is_a: PR:P38398 ! breast cancer type 1 susceptibility protein (human) relationship: has_part MOD:01149 ! sumoylated lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046514 name: breast cancer type 1 susceptibility protein sumoylated form (human) def: "A breast cancer type 1 susceptibility protein (human) that includes at least one sumoylated lysine. UniProtKB:P38398, MOD:01149." [PRO:DNx, Reactome:R-HSA-2997624] comment: Category=organism-modification. synonym: "hBRCA1/SumoLys+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38398, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2997624 "PR:000046514 located_in GO:0005654" intersection_of: has_part MOD:01149 ! sumoylated lysine intersection_of: PR:P38398 ! breast cancer type 1 susceptibility protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O54952 name: breast cancer type 1 susceptibility protein homolog (rat) def: "A breast cancer type 1 susceptibility protein that is encoded in the genome of rat." [PANTHER:PTHR13763:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "Brca1" RELATED Gene-based [UniProtKB:O54952] synonym: "rBRCA1" EXACT PRO-short-label [PRO:DNx] synonym: "RING-type E3 ubiquitin transferase BRCA1 (rat)" EXACT [UniProtKB:O54952] xref: UniProtKB:O54952 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000004803 ! breast cancer type 1 susceptibility protein relationship: has_gene_template RGD:2218 ! Brca1 (rat) [Term] id: PR:P48754 name: breast cancer type 1 susceptibility protein homolog (mouse) def: "A breast cancer type 1 susceptibility protein that is encoded in the genome of mouse." [OMA:P48754, PRO:DNx] comment: Category=organism-gene. synonym: "Brca1" RELATED Gene-based [UniProtKB:P48754] synonym: "mBRCA1" EXACT PRO-short-label [PRO:DNx] synonym: "RING-type E3 ubiquitin transferase BRCA1 (mouse)" EXACT [UniProtKB:P48754] xref: UniProtKB:P48754 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000004803 ! breast cancer type 1 susceptibility protein relationship: has_gene_template MGI:104537 ! Brca1 (mouse) [Term] id: PR:000004803 name: breast cancer type 1 susceptibility protein def: "A BRCA protein that is a translation product of the human BRCA1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BRCA1" EXACT PRO-short-label [PRO:DNx] synonym: "RNF53" RELATED Gene-based [] synonym: "RING finger protein 53" EXACT [] synonym: "RING-type E3 ubiquitin transferase BRCA1" EXACT [] is_a: PR:000050013 ! BRCA protein [Term] id: PR:000045770 name: breast cancer type 1 susceptibility protein isoform 1 phosphorylated 1 (human) def: "A breast cancer type 1 susceptibility protein isoform 1 (human) that has been phosphorylated at position Thr-509. UniProtKB:P38398-1, Thr-509, MOD:00047." [PMID:10542266, iPTMnet:P38398] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10542266). synonym: "hBRCA1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38398-1, Thr-509, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P38398-1 ! breast cancer type 1 susceptibility protein isoform 1 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q54C05 name: uncharacterized protein, DDB_G0293300 translation product (Dictyostelium discoideum) def: "A breast cancer type 1 susceptibility protein that is encoded in the genome of Dictyostelium discoideum." [PANTHER:PTHR13763:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "Dicty-BRCA1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q54C05 intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum intersection_of: PR:000004803 ! breast cancer type 1 susceptibility protein relationship: has_gene_template dictyBase:DDB_G0293300 ! DDB_G0293300 (Dictyostelium discoideum)