[Term]
id: PR:000027487
name: beclin-1 isoform 1 unmodified form (human)
def: "A beclin-1 isoform 1 unmodified form in human." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hBECN1/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027486 ! beclin-1 isoform 1 unmodified form

[Term]
id: PR:000027486
name: beclin-1 isoform 1 unmodified form
def: "A beclin-1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]
comment: Category=modification.
synonym: "BECN1/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
intersection_of: PR:000027468 ! beclin-1 isoform 1
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:Q14457
name: beclin-1 (human)
def: "A beclin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14457]
comment: Category=organism-gene.
synonym: "BECN1" RELATED Gene-based [UniProtKB:Q14457]
synonym: "GT197" RELATED Gene-based [UniProtKB:Q14457]
synonym: "hBECN1" EXACT PRO-short-label [PRO:DNx]
synonym: "protein GT197 (human)" EXACT [UniProtKB:Q14457]
synonym: "coiled-coil myosin-like BCL2-interacting protein (human)" EXACT [UniProtKB:Q14457]
xref: Reactome:R-HSA-1632841 "PR:Q14457 located_in GO:0005829"
xref: UniProtKB:Q14457
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004719 ! beclin-1
relationship: has_gene_template HGNC:1034 ! BECN1 (human)

[Term]
id: PR:Q5ZKS6
name: beclin-1 (chicken)
def: "A beclin-1 that is encoded in the genome of chicken." [OMA:Q5ZKS6, PANTHER:PTHR12768:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "BECN1" RELATED Gene-based [UniProtKB:Q5ZKS6]
synonym: "chick-BECN1" EXACT PRO-short-label [PRO:DNx]
synonym: "RCJMB04_9f22" RELATED Gene-based [UniProtKB:Q5ZKS6]
xref: UniProtKB:Q5ZKS6
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000004719 ! beclin-1
relationship: has_gene_template NCBIGene:420018 ! BECN1 (chicken)

[Term]
id: PR:Q91XJ1
name: beclin-1 (rat)
def: "A beclin-1 that is encoded in the genome of rat." [OMA:Q91XJ1, PANTHER:PTHR12768:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Becn1" RELATED Gene-based [UniProtKB:Q91XJ1]
synonym: "rBECN1" EXACT PRO-short-label [PRO:DNx]
synonym: "protein GT197 (rat)" EXACT [UniProtKB:Q91XJ1]
synonym: "coiled-coil myosin-like BCL2-interacting protein (rat)" EXACT [UniProtKB:Q91XJ1]
xref: UniProtKB:Q91XJ1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000004719 ! beclin-1
relationship: has_gene_template RGD:620190 ! Becn1 (rat)

[Term]
id: PR:000027468
name: beclin-1 isoform 1
def: "A beclin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14457-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "BECN1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000004719 ! beclin-1

[Term]
id: PR:000046479
name: beclin-1 ubiquitinated form (human)
def: "A beclin-1 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q14457, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782989]
comment: Category=organism-modification.
synonym: "hBECN1/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14457, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782989 "PR:000046479 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:Q14457 ! beclin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046478
name: beclin-1 phosphorylated 2 (human)
def: "A beclin-1 (human) that has been post-translationally modified to include phosphoserine at position 15 of the amino acid sequence represented by UniProtKB:Q14457. UniProtKB:Q14457, Ser-15, MOD:00046." [PRO:DNx, Reactome:R-HSA-5682391]
comment: Category=organism-modification.
synonym: "hBECN1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14457, Ser-15, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5682391 "PR:000046478 located_in GO:0005829"
is_a: PR:Q14457 ! beclin-1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:F1RCP1
name: beclin-1 (zebrafish)
def: "A beclin-1 that is encoded in the genome of zebrafish." [OMA:F1RCP1, PRO:DNx]
comment: Category=organism-gene.
synonym: "becn1" RELATED Gene-based [UniProtKB:F1RCP1]
synonym: "z-BECN1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:F1RCP1
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000004719 ! beclin-1
relationship: has_gene_template ZFIN:ZDB-GENE-040426-1666 ! becn1 (zebrafish)

[Term]
id: PR:000049933
name: beclin-1 unphosphorylated 3 (human)
def: "A beclin-1 unphosphorylated 3 in human. UniProtKB:Q14457, Tyr-233, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "hBECN1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14457, Tyr-233, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000049931 ! beclin-1 unphosphorylated 3

[Term]
id: PR:000049932
name: beclin-1 phosphorylated 3 (human)
def: "A beclin-1 phosphorylated 3 in human. UniProtKB:Q14457, Tyr-233, MOD:00048." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "hBECN1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14457, Tyr-233, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000049930 ! beclin-1 phosphorylated 3
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000049931
name: beclin-1 unphosphorylated 3
def: "A beclin-1 that lacks phosphorylation at a Tyr residue equivalent to Tyr-233 of the amino acid sequence represented by UniProtKB:Q14457. Example: UniProtKB:Q14457, Tyr-233, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "BECN1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000004719 ! beclin-1

[Term]
id: PR:000049930
name: beclin-1 phosphorylated 3
def: "A beclin-1 that has been phosphorylated at a Tyr residue, located in the central coil-coiled region, equivalent to Tyr-233 of the amino acid sequence represented by UniProtKB:Q14457. Example: UniProtKB:Q14457, Tyr-233, MOD:00048." [PMID:27994061, PRO:LN]
comment: Category=modification. Evidence=(ECO:0000006, based on PMID:27994061). Kinase=("PTK2"; PR:000003031).
synonym: "BECN1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000004719 ! beclin-1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000049937
name: beclin-1 unphosphorylated 3 (rat)
def: "A beclin-1 unphosphorylated 3 in rat. UniProtKB:Q91XJ1, Tyr-231, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "rBECN1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q91XJ1, Tyr-231, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000049931 ! beclin-1 unphosphorylated 3

[Term]
id: PR:000049936
name: beclin-1 phosphorylated 3 (rat)
def: "A beclin-1 phosphorylated 3 in rat. UniProtKB:Q91XJ1, Tyr-231, MOD:00048." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "rBECN1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q91XJ1, Tyr-231, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000049930 ! beclin-1 phosphorylated 3
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000049935
name: beclin-1 unphosphorylated 3 (mouse)
def: "A beclin-1 unphosphorylated 3 in mouse. UniProtKB:O88597, Tyr-231, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "mBECN1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O88597, Tyr-231, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049931 ! beclin-1 unphosphorylated 3

[Term]
id: PR:000049934
name: beclin-1 phosphorylated 3 (mouse)
def: "A beclin-1 phosphorylated 3 in mouse. UniProtKB:O88597, Tyr-231, MOD:00048." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "mBECN1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O88597, Tyr-231, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049930 ! beclin-1 phosphorylated 3
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:O88597
name: beclin-1 (mouse)
def: "A beclin-1 that is encoded in the genome of mouse." [OMA:O88597, PRO:DNx]
comment: Category=organism-gene.
synonym: "Becn1" RELATED Gene-based [UniProtKB:O88597]
synonym: "mBECN1" EXACT PRO-short-label [PRO:DNx]
synonym: "coiled-coil myosin-like BCL2-interacting protein (mouse)" EXACT [UniProtKB:O88597]
xref: UniProtKB:O88597
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000004719 ! beclin-1
relationship: has_gene_template MGI:1891828 ! Becn1 (mouse)

[Term]
id: PR:000045927
name: beclin-1 phosphorylated 1 (human)
def: "A beclin-1 (human) that has been phosphorylated at Thr-108. UniProtKB:Q14457, Thr-108, MOD:00047." [PMID:24141421, iPTMnet:Q14457]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:24141421). Status=unreviewed.
synonym: "hBECN1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14457, Thr-108, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q14457 ! beclin-1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000004719
name: beclin-1
def: "A protein that is a translation product of the human BECN1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "BECN1" EXACT PRO-short-label [PRO:DNx]
synonym: "GT197" RELATED Gene-based []
synonym: "protein GT197" EXACT []
synonym: "coiled-coil myosin-like BCL2-interacting protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:O88597-1
name: beclin-1 isoform 1 (mouse)
def: "A beclin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mBECN1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O88597-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027468 ! beclin-1 isoform 1

[Term]
id: PR:000027470
name: beclin-1 isoform 1 phosphorylated 1
def: "A beclin-1 isoform 1 that has been phosphorylated on a critical residue withing the BH3 domain. Example: UniProtKB:Q14457-1, Thr-119, MOD:00047." [PMID:19180116, PMID:19395874, PRO:PD]
comment: Category=modification.
synonym: "BECN1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027468 ! beclin-1 isoform 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027471
name: beclin-1 isoform 1 phosphorylated 1 (human)
def: "A beclin-1 isoform 1 phosphorylated 1 in human. UniProtKB:Q14457-1, Thr-119, MOD:00047." [PMID:19180116, PMID:19395874, PRO:PD]
comment: Category=organism-modification. Kinase=("DAPK"; PR:000029896; Thr-119).
synonym: "hBECN1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14457-1, Thr-119, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027470 ! beclin-1 isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q14457-1
name: beclin-1 isoform 1 (human)
def: "A beclin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hBECN1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14457-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027468 ! beclin-1 isoform 1