[Term]
id: PR:Q9Y5Z0
name: beta-secretase 2 (human)
def: "A beta-secretase 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y5Z0]
comment: Category=organism-gene.
synonym: "AEPLC" RELATED Gene-based [UniProtKB:Q9Y5Z0]
synonym: "ALP56" RELATED Gene-based [UniProtKB:Q9Y5Z0]
synonym: "ASP21" RELATED Gene-based [UniProtKB:Q9Y5Z0]
synonym: "BACE2" RELATED Gene-based [UniProtKB:Q9Y5Z0]
synonym: "CDA13" RELATED Gene-based [UniProtKB:Q9Y5Z0]
synonym: "hBACE2" EXACT PRO-short-label [PRO:DNx]
synonym: "ASP1 (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "DRAP (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "Asp 1 (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "UNQ418/PRO852" RELATED Gene-based [UniProtKB:Q9Y5Z0]
synonym: "memapsin-1 (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "theta-secretase (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "aspartyl protease 1 (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "Down region aspartic protease (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "aspartic-like protease 56 kDa (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "beta-site APP cleaving enzyme 2 (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "membrane-associated aspartic protease 1 (human)" EXACT [UniProtKB:Q9Y5Z0]
synonym: "beta-site amyloid precursor protein cleaving enzyme 2 (human)" EXACT [UniProtKB:Q9Y5Z0]
xref: UniProtKB:Q9Y5Z0
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004616 ! beta-secretase 2
relationship: has_gene_template HGNC:934 ! BACE2 (human)

[Term]
id: PR:000058396
name: beta-secretase 2 O-glycosylated 1 (human)
def: "A beta-secretase 2 (human) that has been O-glycosylated at the residue equivalent to Ser-70 of the amino acid sequence represented by UniProtKB:Q9Y5Z0-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q9Y5Z0-1, Ser-70, MOD:00002~GNO:G43417UB." [GlyGen:Q9Y5Z0-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hBACE2/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y5Z0-1, Ser-70, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9Y5Z0 ! beta-secretase 2 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y5Z0-2
name: beta-secretase 2 isoform h2 (human)
def: "A beta-secretase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5Z0-2." [PRO:DNx, UniProtKB:Q9Y5Z0]
comment: Category=organism-sequence.
synonym: "hBACE2/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-secretase 2 isoform Isoform C (human)" EXACT [UniProtKB:Q9Y5Z0]
xref: UniProtKB:Q9Y5Z0-2
is_a: PR:Q9Y5Z0 ! beta-secretase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y5Z0-3
name: beta-secretase 2 isoform h3 (human)
def: "A beta-secretase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5Z0-3." [PRO:DNx, UniProtKB:Q9Y5Z0]
comment: Category=organism-sequence.
synonym: "hBACE2/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-secretase 2 isoform Isoform B (human)" EXACT [UniProtKB:Q9Y5Z0]
xref: UniProtKB:Q9Y5Z0-3
is_a: PR:Q9Y5Z0 ! beta-secretase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y5Z0-1
name: beta-secretase 2 isoform h1 (human)
def: "A beta-secretase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5Z0-1." [PRO:DNx, UniProtKB:Q9Y5Z0]
comment: Category=organism-sequence.
synonym: "hBACE2/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-secretase 2 isoform Isoform A (human)" EXACT [UniProtKB:Q9Y5Z0]
xref: UniProtKB:Q9Y5Z0-1
is_a: PR:Q9Y5Z0 ! beta-secretase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y5Z0-4
name: beta-secretase 2 isoform h4 (human)
def: "A beta-secretase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5Z0-4." [PRO:DNx, UniProtKB:Q9Y5Z0]
comment: Category=organism-sequence.
synonym: "hBACE2/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y5Z0-4
is_a: PR:Q9Y5Z0 ! beta-secretase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y5Z0-5
name: beta-secretase 2 isoform h5 (human)
def: "A beta-secretase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5Z0-5." [PRO:DNx, UniProtKB:Q9Y5Z0]
comment: Category=organism-sequence.
synonym: "hBACE2/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y5Z0-5
is_a: PR:Q9Y5Z0 ! beta-secretase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000004616
name: beta-secretase 2
def: "A protein that is a translation product of the human BACE2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene. Requested by=Alzforum.
synonym: "ASP1" EXACT []
synonym: "DRAP" EXACT []
synonym: "AEPLC" RELATED Gene-based []
synonym: "ALP56" RELATED Gene-based []
synonym: "ASP21" RELATED Gene-based []
synonym: "Asp 1" EXACT []
synonym: "BACE2" EXACT PRO-short-label [PRO:DNx]
synonym: "CDA13" RELATED Gene-based []
synonym: "memapsin-1" EXACT []
synonym: "UNQ418/PRO852" RELATED Gene-based []
synonym: "theta-secretase" EXACT []
synonym: "aspartyl protease 1" EXACT []
synonym: "aspartic-like protease 56 kDa" EXACT []
synonym: "down region aspartic protease" EXACT []
synonym: "beta-site APP cleaving enzyme 2" EXACT []
synonym: "membrane-associated aspartic protease 1" EXACT []
synonym: "beta-site amyloid precursor protein cleaving enzyme 2" EXACT []
xref: IUPHARobj:2331
is_a: PR:000000001 ! protein