[Term]
id: PR:P56817
name: beta-secretase 1 (human)
def: "A beta-secretase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P56817]
comment: Category=organism-gene.
synonym: "BACE" RELATED Gene-based [UniProtKB:P56817]
synonym: "BACE1" RELATED Gene-based [UniProtKB:P56817]
synonym: "hBACE1" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1149" RELATED Gene-based [UniProtKB:P56817]
synonym: "ASP2 (human)" EXACT [UniProtKB:P56817]
synonym: "Asp 2 (human)" EXACT [UniProtKB:P56817]
synonym: "memapsin-2 (human)" EXACT [UniProtKB:P56817]
synonym: "aspartyl protease 2 (human)" EXACT [UniProtKB:P56817]
synonym: "beta-site APP cleaving enzyme 1 (human)" EXACT [UniProtKB:P56817]
synonym: "membrane-associated aspartic protease 2 (human)" EXACT [UniProtKB:P56817]
synonym: "beta-site amyloid precursor protein cleaving enzyme 1 (human)" EXACT [UniProtKB:P56817]
xref: Reactome:R-HSA-5692933 "PR:P56817 located_in GO:0005886"
xref: UniProtKB:P56817
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004615 ! beta-secretase 1
relationship: has_gene_template HGNC:933 ! BACE1 (human)

[Term]
id: PR:P56817-6
name: beta-secretase 1 isoform h6 (human)
def: "A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-6." [PRO:DNx, UniProtKB:P56817]
comment: Category=organism-sequence.
synonym: "hBACE1/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P56817-6
is_a: PR:P56817 ! beta-secretase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P56817-5
name: beta-secretase 1 isoform h5 (human)
def: "A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-5." [PRO:DNx, UniProtKB:P56817]
comment: Category=organism-sequence.
synonym: "hBACE1/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P56817-5
is_a: PR:P56817 ! beta-secretase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P56817-4
name: beta-secretase 1 isoform D (human)
def: "A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-4." [PRO:DNx, UniProtKB:P56817]
comment: Category=organism-sequence.
synonym: "hBACE1/iso:D" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-secretase 1 isoform BACE-1D (human)" EXACT [UniProtKB:P56817]
synonym: "beta-secretase 1 isoform BACE-I-432 (human)" EXACT [UniProtKB:P56817]
xref: UniProtKB:P56817-4
is_a: PR:P56817 ! beta-secretase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P56817-3
name: beta-secretase 1 isoform C (human)
def: "A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-3." [PRO:DNx, UniProtKB:P56817]
comment: Category=organism-sequence.
synonym: "hBACE1/iso:C" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-secretase 1 isoform BACE-1C (human)" EXACT [UniProtKB:P56817]
synonym: "beta-secretase 1 isoform BACE-I-457 (human)" EXACT [UniProtKB:P56817]
xref: UniProtKB:P56817-3
is_a: PR:P56817 ! beta-secretase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P56817-2
name: beta-secretase 1 isoform B (human)
def: "A beta-secretase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56817-2." [PRO:DNx, UniProtKB:P56817]
comment: Category=organism-sequence.
synonym: "hBACE1/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-secretase 1 isoform BACE-1B (human)" EXACT [UniProtKB:P56817]
synonym: "beta-secretase 1 isoform BACE-I-476 (human)" EXACT [UniProtKB:P56817]
xref: UniProtKB:P56817-2
is_a: PR:P56817 ! beta-secretase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P56817-1
name: beta-secretase 1 isoform A (human)
def: "A beta-secretase 1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hBACE1/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-secretase 1 isoform BAC-501 (human)" EXACT [UniProtKB:P56817]
synonym: "beta-secretase 1 isoform BACE-1A (human)" EXACT [UniProtKB:P56817]
xref: UniProtKB:P56817-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039837 ! beta-secretase 1 isoform 1

[Term]
id: PR:000004615
name: beta-secretase 1
def: "A protein that is a translation product of the human BACE1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene. Requested by=Alzforum.
synonym: "ASP2" EXACT []
synonym: "BACE" RELATED Gene-based []
synonym: "Asp 2" EXACT []
synonym: "BACE1" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1149" RELATED Gene-based []
synonym: "memapsin-2" EXACT []
synonym: "aspartyl protease 2" EXACT []
synonym: "beta-site APP cleaving enzyme 1" EXACT []
synonym: "membrane-associated aspartic protease 2" EXACT []
synonym: "beta-site amyloid precursor protein cleaving enzyme 1" EXACT []
xref: IUPHARobj:2330
is_a: PR:000000001 ! protein

[Term]
id: PR:000046453
name: beta-secretase 1, signal peptide removed form (human)
def: "A beta-secretase 1 (human) that has had the signal peptide removed. UniProtKB:P56817, 22-501." [PRO:DNx, Reactome:R-HSA-6783326]
comment: Category=organism-modification.
synonym: "hBACE1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P56817, 22-501" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6783326 "PR:000046453 located_in GO:0005788"
intersection_of: PR:P56817 ! beta-secretase 1 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046454
name: beta-secretase 1, signal peptide removed acetylated 1 (human)
def: "A beta-secretase 1 (human) that has had the signal peptide removed and has been post-translationally modified to include N6-acetyllysine at positions 126, 275, 279, 285, 299, 300 and 307 of the amino acid sequence represented by UniProtKB:P56817. UniProtKB:P56817, 22-501, Lys-126/Lys-275/Lys-279/Lys-285/Lys-299/Lys-300/Lys-307, MOD:00064." [PRO:DNx, Reactome:R-HSA-5693006, Reactome:R-HSA-5693095]
comment: Category=organism-modification.
synonym: "hBACE1/SigPep-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P56817, 22-501, Lys-126/Lys-275/Lys-279/Lys-285/Lys-299/Lys-300/Lys-307, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5693006 "PR:000046454 located_in GO:0005788"
xref: Reactome:R-HSA-5693095 "PR:000046454 located_in GO:0070931"
is_a: PR:P56817 ! beta-secretase 1 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000045841
name: beta-secretase 1 phosphorylated 1 (human)
def: "A beta-secretase 1 (human) that has been phosphorylated at the position equivalent to Thr-252 of the amino acid sequence represented by UniProtKB:P56817-1. Example: UniProtKB:P56817-1, Thr-252, MOD:00047." [PMID:26317805, iPTMnet:P56817]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26317805). Status=unreviewed.
synonym: "hBACE1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P56817-1, Thr-252, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P56817 ! beta-secretase 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens