[Term]
id: PR:000004192
name: serine/threonine-protein kinase A-Raf
def: "A protein that is a translation product of the human ARAF gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PKS" RELATED Gene-based []
synonym: "ARAF" EXACT PRO-short-label [PRO:DNx]
synonym: "PKS2" RELATED Gene-based []
synonym: "A-raf" RELATED Gene-based []
synonym: "ARAF1" RELATED Gene-based []
synonym: "proto-oncogene Pks" EXACT []
synonym: "proto-oncogene A-Raf" EXACT []
synonym: "proto-oncogene A-Raf-1" EXACT []
synonym: "A-Raf proto-oncogene serine/threonine-protein kinase" EXACT []
xref: IUPHARobj:1933
is_a: PR:000000001 ! protein

[Term]
id: PR:P10398-2
name: serine/threonine-protein kinase A-Raf isoform h2 (human)
def: "A serine/threonine-protein kinase A-Raf (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10398-2." [PRO:DNx, UniProtKB:P10398]
comment: Category=organism-sequence.
synonym: "hARAF/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase A-Raf isoform DA-Raf1 (human)" EXACT [UniProtKB:P10398]
xref: UniProtKB:P10398-2
is_a: PR:P10398 ! serine/threonine-protein kinase A-Raf (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P10398
name: serine/threonine-protein kinase A-Raf (human)
def: "A serine/threonine-protein kinase A-Raf that is encoded in the genome of human." [PRO:DNx, UniProtKB:P10398]
comment: Category=organism-gene.
synonym: "PKS" RELATED Gene-based [UniProtKB:P10398]
synonym: "ARAF" RELATED Gene-based [UniProtKB:P10398]
synonym: "PKS2" RELATED Gene-based [UniProtKB:P10398]
synonym: "ARAF1" RELATED Gene-based [UniProtKB:P10398]
synonym: "hARAF" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene Pks (human)" EXACT [UniProtKB:P10398]
synonym: "proto-oncogene A-Raf (human)" EXACT [UniProtKB:P10398]
synonym: "proto-oncogene A-Raf-1 (human)" EXACT [UniProtKB:P10398]
xref: DTO:03100030
xref: UniProtKB:P10398
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004192 ! serine/threonine-protein kinase A-Raf
relationship: has_gene_template HGNC:646 ! ARAF (human)

[Term]
id: PR:000046371
name: serine/threonine-protein kinase A-Raf phosphorylated 1 (human)
def: "A serine/threonine-protein kinase A-Raf (human) that has been post-translationally modified to include phosphoserine at positions 214 and 582 of the amino acid sequence represented by UniProtKB:P10398. UniProtKB:P10398, Ser-214/Ser-582, MOD:00046." [PRO:DAN, Reactome:R-HSA-5672639]
comment: Category=organism-modification. Note: The modified site indicated here (Ser-582) is referred to as Ser-576 in some manuscripts. [PRO:DAN, PMID:21779496]
synonym: "hARAF/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10398, Ser-214/Ser-582, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-5672639 "PR:000046371 located_in GO:0005829"
is_a: PR:P10398 ! serine/threonine-protein kinase A-Raf (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046372
name: serine/threonine-protein kinase A-Raf phosphorylated 2 (human)
def: "A serine/threonine-protein kinase A-Raf (human) that has been post-translationally modified to include phosphoserine at positions 299 and 582, phosphotyrosine at position 302, and phosphothreonine at positions 452 and 455 of the amino acid sequence represented by UniProtKB:P10398. UniProtKB:P10398, Ser-299/Ser-582, MOD:00046|Tyr-302, MOD:00048|Thr-452/Thr-455, MOD:00047." [PRO:DAN, Reactome:R-HSA-5672646, Reactome:R-HSA-5672648]
comment: Category=organism-modification. Note: The modified site indicated here (Ser-582) is referred to as Ser-576 in some manuscripts. [PRO:DAN, PMID:21779496]
synonym: "hARAF/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10398, Ser-299/Ser-582, MOD:00046|Tyr-302, MOD:00048|Thr-452/Thr-455, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-5672646 "PR:000046372 located_in GO:0005829"
xref: Reactome:R-HSA-5672648 "PR:000046372 located_in GO:0005886"
is_a: PR:P10398 ! serine/threonine-protein kinase A-Raf (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046373
name: serine/threonine-protein kinase A-Raf phosphorylated 3 (human)
def: "A serine/threonine-protein kinase A-Raf (human) that has been post-translationally modified to include phosphoserine at position 582 of the amino acid sequence represented by UniProtKB:P10398. UniProtKB:P10398, Ser-582, MOD:00046." [PRO:DAN, Reactome:R-HSA-5672681]
comment: Category=organism-modification. Note: The modified site indicated here (Ser-582) is referred to as Ser-576 in some manuscripts. [PRO:DAN, PMID:21779496]
synonym: "hARAF/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10398, Ser-582, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-5672681 "PR:000046373 located_in GO:0005829"
is_a: PR:P10398 ! serine/threonine-protein kinase A-Raf (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P10398-1
name: serine/threonine-protein kinase A-Raf isoform h1 (human)
def: "A serine/threonine-protein kinase A-Raf (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10398-1." [PRO:DNx, UniProtKB:P10398]
comment: Category=organism-sequence.
synonym: "hARAF/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10398-1
is_a: PR:P10398 ! serine/threonine-protein kinase A-Raf (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens