[Term]
id: PR:000004184
name: aquaporin-4
def: "An aquaporin protein that is a translation product of the human AQP4 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "AQP4" EXACT PRO-short-label [PRO:DNx]
synonym: "MIWC" EXACT []
synonym: "WCH4" EXACT []
synonym: "AQP-4" EXACT []
synonym: "mercurial-insensitive water channel" EXACT []
xref: IUPHARobj:691
is_a: PR:000044672 ! aquaporin protein

[Term]
id: PR:P55087-1
name: aquaporin-4 isoform 2 (human)
def: "An aquaporin-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hAQP4/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P55087-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039789 ! aquaporin-4 isoform 1

[Term]
id: PR:P55087
name: aquaporin-4 (human)
def: "An aquaporin-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55087]
comment: Category=organism-gene.
synonym: "AQP4" RELATED Gene-based [UniProtKB:P55087]
synonym: "hAQP4" EXACT PRO-short-label [PRO:DNx]
synonym: "MIWC (human)" EXACT [UniProtKB:P55087]
synonym: "WCH4 (human)" EXACT [UniProtKB:P55087]
synonym: "AQP-4 (human)" EXACT [UniProtKB:P55087]
synonym: "mercurial-insensitive water channel (human)" EXACT [UniProtKB:P55087]
xref: Reactome:R-HSA-431733 "PR:P55087 located_in GO:0005886"
xref: UniProtKB:P55087
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004184 ! aquaporin-4
relationship: has_gene_template HGNC:637 ! AQP4 (human)

[Term]
id: PR:000045838
name: aquaporin-4 phosphorylated 1 (human)
def: "An aquaporin-4 (human) that has been phosphorylated at the position equivalent to Ser-276 of the amino acid sequence represented by UniProtKB:P55087-1. Example: UniProtKB:P55087-1, Ser-276, MOD:00046." [PMID:26013827, iPTMnet:P55087]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26013827). Status=unreviewed.
synonym: "hAQP4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P55087-1, Ser-276, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P55087 ! aquaporin-4 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P55087-2
name: aquaporin-4 isoform 1 (human)
def: "An aquaporin-4 isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hAQP4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P55087-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039790 ! aquaporin-4 isoform 2