[Term]
id: PR:000004127
name: DNA-(apurinic or apyrimidinic site) endonuclease
def: "A protein that is a translation product of the human APEX1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "APE" RELATED Gene-based []
synonym: "APX" RELATED Gene-based []
synonym: "APE1" RELATED Gene-based []
synonym: "APEN" EXACT []
synonym: "APEX" RELATED Gene-based []
synonym: "HAP1" RELATED Gene-based []
synonym: "REF1" RELATED Gene-based []
synonym: "APEX1" EXACT PRO-short-label [PRO:DNx]
synonym: "REF-1" EXACT []
synonym: "APEX nuclease" EXACT []
synonym: "protein REF-1" EXACT []
synonym: "redox factor-1" EXACT []
synonym: "AP endonuclease 1" EXACT []
synonym: "apurinic-apyrimidinic endonuclease 1" EXACT []
synonym: "DNA-(apurinic or apyrimidinic site) lyase" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P27695
name: DNA-(apurinic or apyrimidinic site) endonuclease (human)
def: "A DNA-(apurinic or apyrimidinic site) endonuclease that is encoded in the genome of human." [PRO:DNx, UniProtKB:P27695]
comment: Category=organism-gene.
synonym: "APE" RELATED Gene-based [UniProtKB:P27695]
synonym: "APX" RELATED Gene-based [UniProtKB:P27695]
synonym: "APE1" RELATED Gene-based [UniProtKB:P27695]
synonym: "APEX" RELATED Gene-based [UniProtKB:P27695]
synonym: "HAP1" RELATED Gene-based [UniProtKB:P27695]
synonym: "REF1" RELATED Gene-based [UniProtKB:P27695]
synonym: "APEX1" RELATED Gene-based [UniProtKB:P27695]
synonym: "hAPEX1" EXACT PRO-short-label [PRO:DNx]
synonym: "APEN (human)" EXACT [UniProtKB:P27695]
synonym: "APE-1 (human)" EXACT [UniProtKB:P27695]
synonym: "REF-1 (human)" EXACT [UniProtKB:P27695]
synonym: "APEX nuclease (human)" EXACT [UniProtKB:P27695]
synonym: "redox factor-1 (human)" EXACT [UniProtKB:P27695]
synonym: "AP endonuclease 1 (human)" EXACT [UniProtKB:P27695]
synonym: "apurinic-apyrimidinic endonuclease 1 (human)" EXACT [UniProtKB:P27695]
xref: UniProtKB:P27695
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004127 ! DNA-(apurinic or apyrimidinic site) endonuclease
relationship: has_gene_template HGNC:587 ! APEX1 (human)

[Term]
id: PR:000046353
name: DNA-(apurinic or apyrimidinic site) endonuclease, initiator methionine removed form (human)
def: "A DNA-(apurinic or apyrimidinic site) endonuclease (human) that has had the initiator methionine removed. UniProtKB:P27695, 2-318." [PRO:DNx, Reactome:R-HSA-50119]
comment: Category=organism-modification.
synonym: "PRO_0000200010" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hAPEX1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27695, 2-318" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-50119 "PR:000046353 located_in GO:0005654"
xref: TDR:1031
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P27695 ! DNA-(apurinic or apyrimidinic site) endonuclease (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens