[Term]
id: PR:000056237
name: adenomatous polyposis coli protein N-glycosylated 1 (human)
def: "An adenomatous polyposis coli protein (human) that has been N-glycosylated at the residue equivalent to Asn-1818 of the amino acid sequence represented by UniProtKB:P25054-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P25054-1, Asn-1818, MOD:00160~GNO:G60923RB." [GlyGen:P25054-1, PMID:26791533, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hAPC/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25054-1, Asn-1818, MOD:00160~GNO:G60923RB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P25054 ! adenomatous polyposis coli protein (human)
relationship: has_part GNO:G60923RB ! G60923RB
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P25054-2
name: adenomatous polyposis coli protein isoform h2 (human)
def: "An adenomatous polyposis coli protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25054-2." [PRO:DNx, UniProtKB:P25054]
comment: Category=organism-sequence.
synonym: "hAPC/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "adenomatous polyposis coli protein isoform Short (human)" EXACT [UniProtKB:P25054]
xref: UniProtKB:P25054-2
is_a: PR:P25054 ! adenomatous polyposis coli protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P25054-3
name: adenomatous polyposis coli protein isoform h1B (human)
def: "An adenomatous polyposis coli protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25054-3." [PRO:DNx, UniProtKB:P25054]
comment: Category=organism-sequence.
synonym: "hAPC/iso:h1B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25054-3
is_a: PR:P25054 ! adenomatous polyposis coli protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P25054-1
name: adenomatous polyposis coli protein isoform h1A (human)
def: "An adenomatous polyposis coli protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25054-1." [PRO:DNx, UniProtKB:P25054]
comment: Category=organism-sequence.
synonym: "hAPC/iso:h1A" EXACT PRO-short-label [PRO:DNx]
synonym: "adenomatous polyposis coli protein isoform Long (human)" EXACT [UniProtKB:P25054]
xref: UniProtKB:P25054-1
xref: Reactome:R-HSA-206082 "PR:P25054-1 located_in GO:0005829"
is_a: PR:P25054 ! adenomatous polyposis coli protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046350
name: adenomatous polyposis coli protein phosphorylated and ubiquitinated form (human)
def: "An adenomatous polyposis coli protein (human) that includes at least one phosphorylated residue and at least one ubiquitinated lysine. UniProtKB:P25054, MOD:00696|MOD:01148." [PRO:DNx, Reactome:R-HSA-3009421]
comment: Category=organism-modification.
synonym: "hAPC/PhosUbiq+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25054, MOD:00696|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3009421 "PR:000046350 located_in GO:0005829"
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P25054 ! adenomatous polyposis coli protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046351
name: adenomatous polyposis coli protein ubiquitinated form (human)
def: "An adenomatous polyposis coli protein (human) that includes at least one ubiquitinated lysine. UniProtKB:P25054, MOD:01148." [PRO:DNx, Reactome:R-HSA-5246690]
comment: Category=organism-modification.
synonym: "hAPC/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25054, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5246690 "PR:000046351 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P25054 ! adenomatous polyposis coli protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000030189
name: adenomatous polyposis coli protein phosphorylated 4 (human)
def: "An adenomatous polyposis coli protein phosphorylated 4 in human." [PMID:11283619, PRO:KER]
comment: Category=organism-modification. Kinase=("Bub1"; PR:000004854). Kinase=("GSK3B"; PR:000008288). Note: In vitro.
synonym: "hAPC/Phos:4" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000030188 ! adenomatous polyposis coli protein phosphorylated 4
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000004122
name: adenomatous polyposis coli protein
def: "A protein that is a translation product of the human APC gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "APC" EXACT PRO-short-label [PRO:DNx]
synonym: "DP2.5" RELATED Gene-based []
synonym: "protein APC" EXACT []
synonym: "deleted in polyposis 2.5" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000030183
name: adenomatous polyposis coli protein phosphorylated 1 (human)
def: "An adenomatous polyposis coli protein phosphorylated 1 in human." [PMID:11283619, PRO:KER]
comment: Category=organism-modification. Kinase=("BUB1:BUB3 complex"; PR:000035564). Note: In vitro.
synonym: "hAPC/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000030182 ! adenomatous polyposis coli protein phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:P25054
name: adenomatous polyposis coli protein (human)
def: "An adenomatous polyposis coli protein that is encoded in the genome of human." [PMID:11283619, PMID:20823832, PRO:KER]
comment: Category=organism-gene.
synonym: "APC" RELATED Gene-based [UniProtKB:P25054]
synonym: "hAPC" EXACT PRO-short-label [PRO:DNx]
synonym: "DP2.5" RELATED Gene-based [UniProtKB:P25054]
synonym: "protein APC (human)" EXACT [UniProtKB:P25054]
synonym: "deleted in polyposis 2.5 (human)" EXACT [UniProtKB:P25054]
xref: Reactome:R-HSA-2976015 "PR:P25054 located_in GO:0005829"
xref: Reactome:R-HSA-3361755 "PR:P25054 located_in GO:0005654"
xref: UniProtKB:P25054
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004122 ! adenomatous polyposis coli protein
relationship: has_gene_template HGNC:583 ! APC (human)

[Term]
id: PR:000030187
name: adenomatous polyposis coli protein phosphorylated 3 (human)
def: "An adenomatous polyposis coli protein phosphorylated 3 in human." [PMID:11283619, PRO:KER]
comment: Category=organism-modification. Kinase=("GSK3B"; PR:000008288). Note: In vitro.
synonym: "hAPC/Phos:3" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000030186 ! adenomatous polyposis coli protein phosphorylated 3
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000030185
name: adenomatous polyposis coli protein phosphorylated 2 (human)
def: "An adenomatous polyposis coli protein phosphorylated 2 in human." [PMID:11283619, PRO:KER]
comment: Category=organism-modification. Kinase=("Bub1b-Bub3 complex"; PR:000035563). Note: In vitro.
synonym: "hAPC/Phos:2" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000030184 ! adenomatous polyposis coli protein phosphorylated 2
relationship: has_part MOD:00696 ! phosphorylated residue