[Term]
id: PR:P12527
name: polyunsaturated fatty acid 5-lipoxygenase (rat)
def: "A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of rat." [OMA:P12527, PANTHER:PTHR11771:SF5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Alox5" RELATED Gene-based [UniProtKB:P12527]
synonym: "rALOX5" EXACT PRO-short-label [PRO:DNx]
synonym: "5-LO (rat)" EXACT [UniProtKB:P12527]
synonym: "5-lipoxygenase (rat)" EXACT [UniProtKB:P12527]
synonym: "arachidonate 5-lipoxygenase (rat)" EXACT [UniProtKB:P12527]
xref: UniProtKB:P12527
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003961 ! polyunsaturated fatty acid 5-lipoxygenase
relationship: has_gene_template RGD:2096 ! Alox5 (rat)

[Term]
id: PR:P09917-5
name: polyunsaturated fatty acid 5-lipoxygenase isoform h5 (human)
def: "A polyunsaturated fatty acid 5-lipoxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09917-5." [PRO:DNx, UniProtKB:P09917]
comment: Category=organism-sequence.
synonym: "hALOX5/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "polyunsaturated fatty acid 5-lipoxygenase isoform alpha-10 (human)" EXACT [UniProtKB:P09917]
xref: UniProtKB:P09917-5
is_a: PR:P09917 ! polyunsaturated fatty acid 5-lipoxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P09917-4
name: polyunsaturated fatty acid 5-lipoxygenase isoform h4 (human)
def: "A polyunsaturated fatty acid 5-lipoxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09917-4." [PRO:DNx, UniProtKB:P09917]
comment: Category=organism-sequence.
synonym: "hALOX5/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "polyunsaturated fatty acid 5-lipoxygenase isoform delta-10-13 (human)" EXACT [UniProtKB:P09917]
xref: UniProtKB:P09917-4
is_a: PR:P09917 ! polyunsaturated fatty acid 5-lipoxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003961
name: polyunsaturated fatty acid 5-lipoxygenase
def: "A protein that is a translation product of the human ALOX5 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "5-LO" EXACT []
synonym: "LOG5" RELATED Gene-based []
synonym: "ALOX5" EXACT PRO-short-label [PRO:DNx]
synonym: "5-lipoxygenase" EXACT []
synonym: "arachidonate 5-lipoxygenase" EXACT []
xref: IUPHARobj:1385
is_a: PR:000000001 ! protein

[Term]
id: PR:000027155
name: polyunsaturated fatty acid 5-lipoxygenase isoform 1
def: "A polyunsaturated fatty acid 5-lipoxygenase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48999-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "ALOX5/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003961 ! polyunsaturated fatty acid 5-lipoxygenase

[Term]
id: PR:P09917-3
name: polyunsaturated fatty acid 5-lipoxygenase isoform h3 (human)
def: "A polyunsaturated fatty acid 5-lipoxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09917-3." [PRO:DNx, UniProtKB:P09917]
comment: Category=organism-sequence.
synonym: "hALOX5/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "polyunsaturated fatty acid 5-lipoxygenase isoform delta-p10 (human)" EXACT [UniProtKB:P09917]
xref: UniProtKB:P09917-3
is_a: PR:P09917 ! polyunsaturated fatty acid 5-lipoxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P48999
name: polyunsaturated fatty acid 5-lipoxygenase (mouse)
def: "A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of mouse." [OMA:P48999, PRO:DNx]
comment: Category=organism-gene.
synonym: "Alox5" RELATED Gene-based [UniProtKB:P48999]
synonym: "mALOX5" EXACT PRO-short-label [PRO:DNx]
synonym: "5-LO (mouse)" EXACT [UniProtKB:P48999]
synonym: "5-lipoxygenase (mouse)" EXACT [UniProtKB:P48999]
synonym: "arachidonate 5-lipoxygenase (mouse)" EXACT [UniProtKB:P48999]
xref: UniProtKB:P48999
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003961 ! polyunsaturated fatty acid 5-lipoxygenase
relationship: has_gene_template MGI:87999 ! Alox5 (mouse)

[Term]
id: PR:P09917-1
name: polyunsaturated fatty acid 5-lipoxygenase isoform 1 (human)
def: "A polyunsaturated fatty acid 5-lipoxygenase isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hALOX5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P09917-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027155 ! polyunsaturated fatty acid 5-lipoxygenase isoform 1

[Term]
id: PR:000018962
name: polyunsaturated fatty acid 5-lipoxygenase, initiator methionine removed form
def: "A polyunsaturated fatty acid 5-lipoxygenase that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "ALOX5/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003961 ! polyunsaturated fatty acid 5-lipoxygenase
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P09917-2
name: polyunsaturated fatty acid 5-lipoxygenase isoform h2 (human)
def: "A polyunsaturated fatty acid 5-lipoxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09917-2." [PRO:DNx, UniProtKB:P09917]
comment: Category=organism-sequence.
synonym: "hALOX5/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "polyunsaturated fatty acid 5-lipoxygenase isoform Delta-13 (human)" EXACT [UniProtKB:P09917]
xref: UniProtKB:P09917-2
is_a: PR:P09917 ! polyunsaturated fatty acid 5-lipoxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046325
name: polyunsaturated fatty acid 5-lipoxygenase, initiator methionine removed phosphorylated 1 (human)
def: "A polyunsaturated fatty acid 5-lipoxygenase (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 272 of the amino acid sequence represented by UniProtKB:P09917. UniProtKB:P09917, 2-674, Ser-272, MOD:00046." [PRO:DNx, Reactome:R-HSA-2318765, Reactome:R-HSA-265276]
comment: Category=organism-modification.
synonym: "hALOX5/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09917, 2-674, Ser-272, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-265276 "PR:000046325 located_in GO:0005829"
xref: Reactome:R-HSA-2318765 "PR:000046325 located_in GO:0005635"
is_a: PR:P09917 ! polyunsaturated fatty acid 5-lipoxygenase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000046324
name: polyunsaturated fatty acid 5-lipoxygenase, initiator methionine removed form (human)
def: "A polyunsaturated fatty acid 5-lipoxygenase (human) that has had the initiator methionine removed. UniProtKB:P09917, 2-674." [PRO:DNx, Reactome:R-HSA-429010]
comment: Category=organism-modification.
synonym: "hALOX5/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09917, 2-674" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-429010 "PR:000046324 located_in GO:0005829"
xref: Reactome:R-HSA-6801302 "PR:000046324 located_in GO:1904813"
xref: Reactome:R-HSA-6801306 "PR:000046324 located_in GO:0034774"
xref: Reactome:R-HSA-6806468 "PR:000046324 located_in GO:0005576"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P09917 ! polyunsaturated fatty acid 5-lipoxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P48999-1
name: polyunsaturated fatty acid 5-lipoxygenase isoform 1 (mouse)
def: "A polyunsaturated fatty acid 5-lipoxygenase isoform 1 that is encoded in the genome of mouse." [PMID:7629107, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mALOX5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48999-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027155 ! polyunsaturated fatty acid 5-lipoxygenase isoform 1

[Term]
id: PR:P09917
name: polyunsaturated fatty acid 5-lipoxygenase (human)
def: "A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P09917]
comment: Category=organism-gene.
synonym: "LOG5" RELATED Gene-based [UniProtKB:P09917]
synonym: "ALOX5" RELATED Gene-based [UniProtKB:P09917]
synonym: "hALOX5" EXACT PRO-short-label [PRO:DNx]
synonym: "5-LO (human)" EXACT [UniProtKB:P09917]
synonym: "5-lipoxygenase (human)" EXACT [UniProtKB:P09917]
synonym: "arachidonate 5-lipoxygenase (human)" EXACT [UniProtKB:P09917]
xref: UniProtKB:P09917
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003961 ! polyunsaturated fatty acid 5-lipoxygenase
relationship: has_gene_template HGNC:435 ! ALOX5 (human)