[Term]
id: PR:000003774
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial
def: "A protein that is a translation product of the human ADHFE1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HOT" EXACT []
synonym: "ADHFE1" EXACT PRO-short-label [PRO:DNx]
synonym: "ADHFe1" EXACT []
synonym: "HMFT2263" RELATED Gene-based []
synonym: "Fe-containing alcohol dehydrogenase" EXACT []
synonym: "alcohol dehydrogenase iron-containing protein 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9U2M4
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial (worm)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial that is encoded in the genome of worm." [OMA:Q9U2M4, PRO:DNx]
comment: Category=organism-gene.
synonym: "hphd-1" RELATED Gene-based [UniProtKB:Q9U2M4]
synonym: "Y38F1A.6" RELATED Gene-based [UniProtKB:Q9U2M4]
synonym: "HOT (worm)" EXACT [UniProtKB:Q9U2M4]
synonym: "ADHFE1 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "3-Hydroxypropionate-oxoacid transhydrogenase (worm)" EXACT [UniProtKB:Q9U2M4]
xref: UniProtKB:Q9U2M4
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000003774 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial
relationship: has_gene_template WormBase:WBGene00012608 ! hphd-1 (worm)

[Term]
id: PR:Q8IWW8-2
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform h2 (human)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWW8-2." [PRO:DNx, UniProtKB:Q8IWW8]
comment: Category=organism-sequence.
synonym: "hADHFE1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IWW8-2
is_a: PR:Q8IWW8 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8IWW8-3
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform h3 (human)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWW8-3." [PRO:DNx, UniProtKB:Q8IWW8]
comment: Category=organism-sequence.
synonym: "hADHFE1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IWW8-3
is_a: PR:Q8IWW8 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8IWW8-1
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform h1 (human)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWW8-1." [PRO:DNx, UniProtKB:Q8IWW8]
comment: Category=organism-sequence.
synonym: "hADHFE1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IWW8-1
is_a: PR:Q8IWW8 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8R0N6
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial (mouse)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial that is encoded in the genome of mouse." [OMA:Q8R0N6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Adhfe1" RELATED Gene-based [UniProtKB:Q8R0N6]
synonym: "mADHFE1" EXACT PRO-short-label [PRO:DNx]
synonym: "HOT (mouse)" EXACT [UniProtKB:Q8R0N6]
synonym: "ADHFe1 (mouse)" EXACT [UniProtKB:Q8R0N6]
synonym: "alcohol dehydrogenase iron-containing protein 1 (mouse)" EXACT [UniProtKB:Q8R0N6]
xref: UniProtKB:Q8R0N6
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003774 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial
relationship: has_gene_template MGI:1923437 ! Adhfe1 (mouse)

[Term]
id: PR:Q54GJ7
name: probable hydroxyacid-oxoacid transhydrogenase, mitochondrial (Dictyostelium discoideum)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54GJ7, PRO:DNx]
comment: Category=organism-gene.
synonym: "adhfe1" RELATED Gene-based [UniProtKB:Q54GJ7]
synonym: "DDB_G0290111" RELATED Gene-based [UniProtKB:Q54GJ7]
synonym: "Dicty-ADHFE1" EXACT PRO-short-label [PRO:DNx]
synonym: "HOT (Dictyostelium discoideum)" EXACT [UniProtKB:Q54GJ7]
xref: UniProtKB:Q54GJ7
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000003774 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial
relationship: has_gene_template dictyBase:DDB_G0290111 ! adhfe1 (Dictyostelium discoideum)

[Term]
id: PR:Q8IWW8-4
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform h4 (human)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWW8-4." [PRO:DNx, UniProtKB:Q8IWW8]
comment: Category=organism-sequence.
synonym: "hADHFE1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IWW8-4
is_a: PR:Q8IWW8 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9W265
name: probable hydroxyacid-oxoacid transhydrogenase, mitochondrial (fruit fly)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial that is encoded in the genome of fruit fly." [OMA:Q9W265, PRO:DNx]
comment: Category=organism-gene.
synonym: "T3dh" RELATED Gene-based [UniProtKB:Q9W265]
synonym: "CG3425" RELATED Gene-based [UniProtKB:Q9W265]
synonym: "fly-ADHFE1" EXACT PRO-short-label [PRO:DNx]
synonym: "HOT (fruit fly)" EXACT [UniProtKB:Q9W265]
xref: UniProtKB:Q9W265
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000003774 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial
relationship: has_gene_template FlyBase:FBgn0017482 ! T3dh (fruit fly)

[Term]
id: PR:Q4QQW3
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial (rat)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial that is encoded in the genome of rat." [OMA:Q4QQW3, PRO:DNx]
comment: Category=organism-gene.
synonym: "Adhfe1" RELATED Gene-based [UniProtKB:Q4QQW3]
synonym: "rADHFE1" EXACT PRO-short-label [PRO:DNx]
synonym: "HOT (rat)" EXACT [UniProtKB:Q4QQW3]
synonym: "ADHFe1 (rat)" EXACT [UniProtKB:Q4QQW3]
synonym: "alcohol dehydrogenase iron-containing protein 1 (rat)" EXACT [UniProtKB:Q4QQW3]
xref: UniProtKB:Q4QQW3
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003774 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial
relationship: has_gene_template RGD:1308863 ! Adhfe1 (rat)

[Term]
id: PR:Q09669
name: alcohol dehydrogenase 4 (Schizosaccharomyces pombe 972h-)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09669, PRO:DNx]
comment: Category=organism-gene.
synonym: "adh4" RELATED Gene-based [UniProtKB:Q09669]
synonym: "SPAC5H10.06c" RELATED Gene-based [UniProtKB:Q09669]
synonym: "Spom972h-ADHFE1" EXACT PRO-short-label [PRO:DNx]
synonym: "alcohol dehydrogenase IV (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09669]
xref: UniProtKB:Q09669
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000003774 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial
relationship: has_gene_template PomBase:SPAC5H10.06c ! adh4 (Schizosaccharomyces pombe)

[Term]
id: PR:Q8IWW8
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial (human)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IWW8]
comment: Category=organism-gene.
synonym: "ADHFE1" RELATED Gene-based [UniProtKB:Q8IWW8]
synonym: "hADHFE1" EXACT PRO-short-label [PRO:DNx]
synonym: "HMFT2263" RELATED Gene-based [UniProtKB:Q8IWW8]
synonym: "HOT (human)" EXACT [UniProtKB:Q8IWW8]
synonym: "ADHFe1 (human)" EXACT [UniProtKB:Q8IWW8]
synonym: "Fe-containing alcohol dehydrogenase (human)" EXACT [UniProtKB:Q8IWW8]
synonym: "alcohol dehydrogenase iron-containing protein 1 (human)" EXACT [UniProtKB:Q8IWW8]
xref: UniProtKB:Q8IWW8
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003774 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial
relationship: has_gene_template HGNC:16354 ! ADHFE1 (human)

[Term]
id: PR:Q8R0N6-1
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform m1 (mouse)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R0N6-1." [PRO:DNx, UniProtKB:Q8R0N6]
comment: Category=organism-sequence.
synonym: "mADHFE1/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8R0N6-1
is_a: PR:Q8R0N6 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8R0N6-2
name: hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform m2 (mouse)
def: "A hydroxyacid-oxoacid transhydrogenase, mitochondrial (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R0N6-2." [PRO:DNx, UniProtKB:Q8R0N6]
comment: Category=organism-sequence.
synonym: "mADHFE1/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8R0N6-2
is_a: PR:Q8R0N6 ! hydroxyacid-oxoacid transhydrogenase, mitochondrial (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus