[Term]
id: PR:P12814-4
name: alpha-actinin-1 isoform h4 (human)
def: "An alpha-actinin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12814-4." [PRO:DNx, UniProtKB:P12814]
comment: Category=organism-sequence.
synonym: "hACTN1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P12814-4
is_a: PR:P12814 ! alpha-actinin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P12814
name: alpha-actinin-1 (human)
def: "An alpha-actinin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P12814]
comment: Category=organism-gene.
synonym: "ACTN1" RELATED Gene-based [UniProtKB:P12814]
synonym: "hACTN1" EXACT PRO-short-label [PRO:DNx]
synonym: "non-muscle alpha-actinin-1 (human)" EXACT [UniProtKB:P12814]
synonym: "F-actin cross-linking protein (human)" BROAD [UniProtKB:P12814]
synonym: "alpha-actinin cytoskeletal isoform (human)" EXACT [UniProtKB:P12814]
xref: Reactome:R-HSA-349722 "PR:P12814 located_in GO:0005576"
xref: Reactome:R-HSA-349724 "PR:P12814 located_in GO:0031093"
xref: Reactome:R-HSA-354096 "PR:P12814 located_in GO:0005829"
xref: UniProtKB:P12814
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003688 ! alpha-actinin-1
relationship: has_gene_template HGNC:163 ! ACTN1 (human)

[Term]
id: PR:P12814-1
name: alpha-actinin-1 isoform 1 (human)
def: "An alpha-actinin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hACTN1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P12814-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025710 ! alpha-actinin-1 isoform 1

[Term]
id: PR:P12814-2
name: alpha-actinin-1 isoform h2 (human)
def: "An alpha-actinin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12814-2." [PRO:DNx, UniProtKB:P12814]
comment: Category=organism-sequence.
synonym: "hACTN1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P12814-2
is_a: PR:P12814 ! alpha-actinin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P12814-3
name: alpha-actinin-1 isoform h3 (human)
def: "An alpha-actinin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12814-3." [PRO:DNx, UniProtKB:P12814]
comment: Category=organism-sequence.
synonym: "hACTN1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P12814-3
is_a: PR:P12814 ! alpha-actinin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05094-1
name: alpha-actinin-1 isoform 1 (chicken)
def: "An alpha-actinin-1 (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05094-1." [PRO:DNx, UniProtKB:P05094]
comment: Category=organism-sequence.
synonym: "chick-ACTN1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-actinin-1 isoform Brain (chicken)" EXACT [UniProtKB:P05094]
xref: UniProtKB:P05094-1
is_a: PR:P05094 ! alpha-actinin-1 (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus

[Term]
id: PR:P05094-2
name: alpha-actinin-1 isoform 2 (chicken)
def: "An alpha-actinin-1 (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05094-2." [PRO:DNx, UniProtKB:P05094]
comment: Category=organism-sequence.
synonym: "chick-ACTN1/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-actinin-1 isoform Smooth muscle (chicken)" EXACT [UniProtKB:P05094]
xref: UniProtKB:P05094-2
is_a: PR:P05094 ! alpha-actinin-1 (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus

[Term]
id: PR:Q7TPR4
name: alpha-actinin-1 (mouse)
def: "An alpha-actinin-1 that is encoded in the genome of mouse." [OMA:Q7TPR4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Actn1" RELATED Gene-based [UniProtKB:Q7TPR4]
synonym: "mACTN1" EXACT PRO-short-label [PRO:DNx]
synonym: "non-muscle alpha-actinin-1 (mouse)" EXACT [UniProtKB:Q7TPR4]
synonym: "F-actin cross-linking protein (mouse)" RELATED [UniProtKB:Q7TPR4]
synonym: "alpha-actinin cytoskeletal isoform (mouse)" EXACT [UniProtKB:Q7TPR4]
xref: UniProtKB:Q7TPR4
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003688 ! alpha-actinin-1
relationship: has_gene_template MGI:2137706 ! Actn1 (mouse)

[Term]
id: PR:Q9Z1P2
name: alpha-actinin-1 (rat)
def: "An alpha-actinin-1 that is encoded in the genome of rat." [OMA:Q9Z1P2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Actn1" RELATED Gene-based [UniProtKB:Q9Z1P2]
synonym: "rACTN1" EXACT PRO-short-label [PRO:DNx]
synonym: "non-muscle alpha-actinin-1 (rat)" EXACT [UniProtKB:Q9Z1P2]
synonym: "F-actin cross-linking protein (rat)" EXACT [UniProtKB:Q9Z1P2]
synonym: "alpha-actinin cytoskeletal isoform (rat)" EXACT [UniProtKB:Q9Z1P2]
xref: UniProtKB:Q9Z1P2
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003688 ! alpha-actinin-1
relationship: has_gene_template RGD:70907 ! Actn1 (rat)

[Term]
id: PR:Q7TPR4-1
name: alpha-actinin-1 isoform 1 (mouse)
def: "An alpha-actinin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mACTN1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7TPR4-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025710 ! alpha-actinin-1 isoform 1

[Term]
id: PR:000025711
name: alpha-actinin-1 isoform 1 phosphorylated 1
def: "An alpha-actinin-1 isoform 1 that has been phosphorylated on a Tyr residue at the N-terminal region by active FAK kinase. Example: UniProtKB:P12814-1, Tyr-12, MOD:00048." [PMID:16291744, PRO:JAN]
comment: Category=modification.
synonym: "ACTN1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000025710 ! alpha-actinin-1 isoform 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000025710
name: alpha-actinin-1 isoform 1
def: "An alpha-actinin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12814-1 or a 1:1 ortholog thereof." [PMID:12665801, PRO:CNA]
comment: Category=sequence.
synonym: "ACTN1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003688 ! alpha-actinin-1

[Term]
id: PR:000025712
name: alpha-actinin-1 isoform 1 phosphorylated 1 (human)
def: "An alpha-actinin-1 isoform 1 phosphorylated 1 in human. UniProtKB:P12814-1, Tyr-12, MOD:00048." [PMID:16291744, PRO:JAN]
comment: Category=organism-modification.
synonym: "hACTN1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P12814-1, Tyr-12, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025711 ! alpha-actinin-1 isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P05094
name: alpha-actinin-1 (chicken)
def: "An alpha-actinin-1 that is encoded in the genome of chicken." [OMA:P05094, PRO:DNx]
comment: Category=organism-gene.
synonym: "ACTN1" RELATED Gene-based [UniProtKB:P05094]
synonym: "chick-ACTN1" EXACT PRO-short-label [PRO:DNx]
synonym: "non-muscle alpha-actinin-1 (chicken)" EXACT [UniProtKB:P05094]
synonym: "F-actin cross-linking protein (chicken)" RELATED [UniProtKB:P05094]
synonym: "alpha-actinin cytoskeletal isoform (chicken)" EXACT [UniProtKB:P05094]
xref: UniProtKB:P05094
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000003688 ! alpha-actinin-1
relationship: has_gene_template NCBIGene:373918 ! ACTN1 (chicken)

[Term]
id: PR:000003688
name: alpha-actinin-1
def: "A protein that is a translation product of the human ACTN1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ACTN1" EXACT PRO-short-label [PRO:DNx]
synonym: "non-muscle alpha-actinin-1" EXACT []
synonym: "F-actin cross-linking protein" BROAD [PRO:DNx]
synonym: "alpha-actinin cytoskeletal isoform" EXACT []
is_a: PR:000000001 ! protein