[Term]
id: PR:000046828
name: collagen alpha-1(I) chain, signal peptide removed 5-hydroxy-lysine and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(I) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine and at least one 4-hydroxy-proline. UniProtKB:P02452, 23-1464, MOD:00037|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022951, Reactome:R-HSA-2268643]
comment: Category=organism-modification.
synonym: "hCOL1A1/SigPep-/5hL4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452, 23-1464, MOD:00037|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022951 "PR:000046828 located_in GO:0005788"
xref: Reactome:R-HSA-2268643 "PR:000046828 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02452 ! collagen alpha-1(I) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P11087-1
name: collagen alpha-1(I) chain isoform m1 (mouse)
def: "A collagen alpha-1(I) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11087-1." [PRO:DNx, UniProtKB:P11087]
comment: Category=organism-sequence.
synonym: "mCOL1A1/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11087-1
is_a: PR:P11087 ! collagen alpha-1(I) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000046823
name: collagen alpha-1(I) chain, signal peptide removed form (human)
def: "A collagen alpha-1(I) chain (human) that has had the signal peptide removed. UniProtKB:P02452, 23-1464." [PRO:DNx, Reactome:R-HSA-1650777, Reactome:R-HSA-2268635]
comment: Category=organism-modification.
synonym: "hCOL1A1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452, 23-1464" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1650777 "PR:000046823 located_in GO:0005788"
xref: Reactome:R-HSA-2268635 "PR:000046823 located_in GO:0005576"
intersection_of: PR:P02452 ! collagen alpha-1(I) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P11087
name: collagen alpha-1(I) chain (mouse)
def: "A collagen alpha-1(I) chain that is encoded in the genome of mouse." [OMA:P11087, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cola1" RELATED Gene-based [UniProtKB:P11087]
synonym: "Col1a1" RELATED Gene-based [UniProtKB:P11087]
synonym: "mCOL1A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type I collagen (mouse)" EXACT [UniProtKB:P11087]
xref: UniProtKB:P11087
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003264 ! collagen alpha-1(I) chain
relationship: has_gene_template MGI:88467 ! Col1a1 (mouse)

[Term]
id: PR:P11087-2
name: collagen alpha-1(I) chain isoform m2 (mouse)
def: "A collagen alpha-1(I) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11087-2." [PRO:DNx, UniProtKB:P11087]
comment: Category=organism-sequence.
synonym: "mCOL1A1/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11087-2
is_a: PR:P11087 ! collagen alpha-1(I) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P02454
name: collagen alpha-1(I) chain (rat)
def: "A collagen alpha-1(I) chain that is encoded in the genome of rat." [OMA:P02454, PANTHER:PTHR24023:SF127, PRO:DNx]
comment: Category=organism-gene.
synonym: "Col1a1" RELATED Gene-based [UniProtKB:P02454]
synonym: "rCOL1A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type I collagen (rat)" EXACT [UniProtKB:P02454]
xref: UniProtKB:P02454
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003264 ! collagen alpha-1(I) chain
relationship: has_gene_template RGD:61817 ! Col1a1 (rat)

[Term]
id: PR:000003264
name: collagen alpha-1(I) chain
def: "A collagen type I alpha chain that is a translation product of the human COL1A1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "Cola1" RELATED Gene-based []
synonym: "COL1A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type I collagen" EXACT []
is_a: PR:000003263 ! collagen type I alpha chain

[Term]
id: PR:000003370
name: collagen alpha-1(I) chain isoform 1
def: "A collagen alpha-1(I) chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02452-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "COL1A1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003264 ! collagen alpha-1(I) chain

[Term]
id: PR:000046824
name: collagen alpha-1(I) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(I) chain (human) that has had the signal peptide removed and that includes at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P02452, 23-1464, MOD:00038|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022446, Reactome:R-HSA-2268634]
comment: Category=organism-modification.
synonym: "hCOL1A1/SigPep-/3hP4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452, 23-1464, MOD:00038|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022446 "PR:000046824 located_in GO:0005788"
xref: Reactome:R-HSA-2268634 "PR:000046824 located_in GO:0005576"
intersection_of: has_part MOD:00038 ! 3-hydroxy-L-proline
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02452 ! collagen alpha-1(I) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046825
name: collagen alpha-1(I) chain, signal peptide removed 4-hydroxy-proline form (human)
def: "A collagen alpha-1(I) chain (human) that has had the signal peptide removed and that includes at least one 4-hydroxy-proline. UniProtKB:P02452, 23-1464, MOD:00039." [PRO:DNx, Reactome:R-HSA-1985659, Reactome:R-HSA-2268642]
comment: Category=organism-modification.
synonym: "hCOL1A1/SigPep-/4HyPro+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452, 23-1464, MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1985659 "PR:000046825 located_in GO:0005788"
xref: Reactome:R-HSA-2268642 "PR:000046825 located_in GO:0005576"
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02452 ! collagen alpha-1(I) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046826
name: collagen alpha-1(I) chain, signal peptide removed 5-hydroxy-lysine form (human)
def: "A collagen alpha-1(I) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine. UniProtKB:P02452, 23-1464, MOD:00037." [PRO:DNx, Reactome:R-HSA-1985663, Reactome:R-HSA-2268624]
comment: Category=organism-modification.
synonym: "hCOL1A1/SigPep-/5HyLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452, 23-1464, MOD:00037" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1985663 "PR:000046826 located_in GO:0005788"
xref: Reactome:R-HSA-2268624 "PR:000046826 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: PR:P02452 ! collagen alpha-1(I) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046827
name: collagen alpha-1(I) chain, signal peptide removed 5-hydroxy-lysine, 3-hydroxy-proline and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(I) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine, at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P02452, 23-1464, MOD:00037|MOD:00038|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022954, Reactome:R-HSA-2268648]
comment: Category=organism-modification.
synonym: "hCOL1A1/SigPep-/5hL3hP4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452, 23-1464, MOD:00037|MOD:00038|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022954 "PR:000046827 located_in GO:0005788"
xref: Reactome:R-HSA-2268648 "PR:000046827 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: has_part MOD:00038 ! 3-hydroxy-L-proline
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02452 ! collagen alpha-1(I) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P02452-1
name: collagen alpha-1(I) chain isoform 1 (human)
def: "A collagen alpha-1(I) chain isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCOL1A1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P02452-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003370 ! collagen alpha-1(I) chain isoform 1

[Term]
id: PR:P02452
name: collagen alpha-1(I) chain (human)
def: "A collagen alpha-1(I) chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P02452]
comment: Category=organism-gene.
synonym: "COL1A1" RELATED Gene-based [UniProtKB:P02452]
synonym: "hCOL1A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type I collagen (human)" EXACT [UniProtKB:P02452]
xref: UniProtKB:P02452
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003264 ! collagen alpha-1(I) chain
relationship: has_gene_template HGNC:2197 ! COL1A1 (human)

[Term]
id: PR:000018797
name: collagen alpha-1(I) chain, signal peptide removed form
def: "A collagen alpha-1(I) chain that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "COL1A1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003264 ! collagen alpha-1(I) chain
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000003372
name: collagen alpha-1(I) chain isoform 1 cleaved 1
def: "A collagen alpha-1(I) chain isoform 1, signal peptide removed form that has been processed by subsequent removal of the N- and C-terminal propeptides, yielding the mature protein. Example: UniProtKB:P02452-1, 162-1218." [PRO:CNA]
comment: Category=modification.
synonym: "COL1A1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "collagen alpha-1(I) chain" BROAD [PRO:DNx]
synonym: "collagen alpha-1(I) chain mature" EXACT []
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000021925 ! collagen alpha-1(I) chain isoform 1, signal peptide removed form
intersection_of: lacks_part SO:0001062 ! propeptide

[Term]
id: PR:000018798
name: collagen alpha-1(I) chain proteolytic cleavage product
def: "A collagen alpha-1(I) chain that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "COL1A1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000003264 ! collagen alpha-1(I) chain

[Term]
id: PR:000052475
name: collagen alpha-1(I) chain O-glycosylated 2 (human)
def: "A collagen alpha-1(I) chain (human) that has been O-glycosylated at the residue equivalent to Thr-172 of the amino acid sequence represented by UniProtKB:P02452-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02452-1, Thr-172, MOD:00005~GNO:G43417UB." [GlyGen:P02452-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCOL1A1/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452-1, Thr-172, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P02452 ! collagen alpha-1(I) chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000052476
name: collagen alpha-1(I) chain O-glycosylated 3 (human)
def: "A collagen alpha-1(I) chain (human) that has been O-glycosylated at the residue equivalent to Thr-948 of the amino acid sequence represented by UniProtKB:P02452-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02452-1, Thr-948, MOD:00005~GNO:G43417UB." [GlyGen:P02452-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCOL1A1/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452-1, Thr-948, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P02452 ! collagen alpha-1(I) chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000052474
name: collagen alpha-1(I) chain O-glycosylated 1 (human)
def: "A collagen alpha-1(I) chain (human) that has been O-glycosylated at the residue equivalent to Thr-103 of the amino acid sequence represented by UniProtKB:P02452-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02452-1, Thr-103, MOD:00005~GNO:G43417UB." [GlyGen:P02452-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCOL1A1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02452-1, Thr-103, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P02452 ! collagen alpha-1(I) chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000021925
name: collagen alpha-1(I) chain isoform 1, signal peptide removed form
def: "A collagen alpha-1(I) chain isoform 1 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "COL1A1/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003370 ! collagen alpha-1(I) chain isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide