[Term]
id: PR:P04049-2
name: RAF proto-oncogene serine/threonine-protein kinase isoform 2 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hRAF1/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "RAF proto-oncogene serine/threonine-protein kinase isoform 1A (human)" EXACT [UniProtKB:P04049]
xref: UniProtKB:P04049-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003248 ! RAF proto-oncogene serine/threonine-protein kinase isoform 2

[Term]
id: PR:000036643
name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046." [PMID:15849194, PRO:JAN]
comment: Category=organism-modification.
synonym: "hRAF1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003250 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000048997
name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 3 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 259 and 621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-259/Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-109786]
comment: Category=organism-modification.
synonym: "hRAF1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049, Ser-259/Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-109786 "PR:000048997 located_in GO:0005829"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04049
name: RAF proto-oncogene serine/threonine-protein kinase (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human." [PMID:20703093, PRO:KER]
comment: Category=organism-gene.
synonym: "RAF" RELATED Gene-based [UniProtKB:P04049]
synonym: "RAF1" RELATED Gene-based [UniProtKB:P04049]
synonym: "hRAF1" EXACT PRO-short-label [PRO:DNx]
synonym: "cRaf (human)" EXACT [UniProtKB:P04049]
synonym: "Raf-1 (human)" EXACT [UniProtKB:P04049]
synonym: "proto-oncogene c-RAF (human)" EXACT [UniProtKB:P04049]
xref: Reactome:R-HSA-167205 "PR:P04049 located_in GO:0005829"
xref: DTO:03100445
xref: UniProtKB:P04049
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase
relationship: has_gene_template HGNC:9829 ! RAF1 (human)

[Term]
id: PR:000048998
name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 4 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 29, 43, 259, 296, 301, 338, 494, 621 and 642, phosphotyrosine at position 341, and phosphothreonine at position 491 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-29/Ser-43/Ser-259/Ser-296/Ser-301/Ser-338/Ser-494/Ser-621/Ser-642, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-5675193]
comment: Category=organism-modification.
synonym: "hRAF1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049, Ser-29/Ser-43/Ser-259/Ser-296/Ser-301/Ser-338/Ser-494/Ser-621/Ser-642, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5675193 "PR:000048998 located_in GO:0005886"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048999
name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 5 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at position 338 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338, MOD:00046." [PRO:DNx, Reactome:R-HSA-444236, Reactome:R-HSA-5624469]
comment: Category=organism-modification.
synonym: "hRAF1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049, Ser-338, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-444236 "PR:000048999 located_in GO:0005886"
xref: Reactome:R-HSA-5624469 "PR:000048999 located_in GO:0005829"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04049-1
name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hRAF1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "RAF proto-oncogene serine/threonine-protein kinase isoform 6C (human)" EXACT [UniProtKB:P04049]
xref: UniProtKB:P04049-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003245 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1

[Term]
id: PR:000049002
name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 8 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at position 621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-206028, Reactome:R-HSA-206222]
comment: Category=organism-modification.
synonym: "hRAF1/Phos:8" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049, Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-206028 "PR:000049002 located_in GO:0005829"
xref: Reactome:R-HSA-206222 "PR:000049002 located_in GO:0005886"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003244
name: RAF proto-oncogene serine/threonine-protein kinase
def: "A protein that is a translation product of the human RAF1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "RAF" RELATED Gene-based []
synonym: "RAF1" EXACT PRO-short-label [PRO:DNx]
synonym: "cRaf" EXACT []
synonym: "Raf-1" EXACT []
synonym: "proto-oncogene c-RAF" EXACT []
xref: IUPHARobj:2184
is_a: PR:000000001 ! protein

[Term]
id: PR:000049000
name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 6 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at position 338, and phosphotyrosine at positions 340 and 341 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338, MOD:00046|Tyr-340/Tyr-341, MOD:00048." [PRO:DNx, Reactome:R-HSA-5624465]
comment: Category=organism-modification.
synonym: "hRAF1/Phos:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049, Ser-338, MOD:00046|Tyr-340/Tyr-341, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5624465 "PR:000049000 located_in GO:0005829"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049003
name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 9 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphotyrosine at position 341, phosphothreonine at position 491, and phosphoserine at positions 494 and 621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Tyr-341, MOD:00048|Thr-491, MOD:00047|Ser-494/Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-5675420]
comment: Category=organism-modification.
synonym: "hRAF1/Phos:9" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049, Tyr-341, MOD:00048|Thr-491, MOD:00047|Ser-494/Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5675420 "PR:000049003 located_in GO:0005886"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026210
name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 in human. UniProtKB:P04049-1, Ser-259/Ser-621, MOD:00046." [PMID:14688280, PRO:CNA]
comment: Category=organism-modification.
synonym: "hRAF1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049-1, Ser-259/Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026174 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000049001
name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 7 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 338, 494 and 621, phosphotyrosine at position 341, and phosphothreonine at position 491 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-5672664, Reactome:R-HSA-5672665]
comment: Category=organism-modification.
synonym: "hRAF1/Phos:7" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5672664 "PR:000049001 located_in GO:0005829"
xref: Reactome:R-HSA-5672665 "PR:000049001 located_in GO:0005886"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045631
name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 1 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated at the position equivalent to Thr-269 of the amino acid sequence represented by UniProtKB:P04049-1. Example: UniProtKB:P04049-1, Thr-269, MOD:00047." [PMID:7477354, iPTMnet:P04049]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:7477354). Status=unreviewed.
synonym: "hRAF1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04049-1, Thr-269, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens