[Term]
id: PR:P0C8E4
name: mitogen-activated protein kinase kinase kinase 7 (rat)
def: "A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of rat." [OMA:P0C8E4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Map3k7" RELATED Gene-based [UniProtKB:P0C8E4]
synonym: "rMAP3K7" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P0C8E4
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003158 ! mitogen-activated protein kinase kinase kinase 7
relationship: has_gene_template RGD:1309438 ! Map3k7 (rat)

[Term]
id: PR:Q62073
name: mitogen-activated protein kinase kinase kinase 7 (mouse)
def: "A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of mouse." [OMA:Q62073, PRO:CNA]
comment: Category=organism-gene.
synonym: "Tak1" RELATED Gene-based [UniProtKB:Q62073]
synonym: "Map3k7" RELATED Gene-based [UniProtKB:Q62073]
synonym: "mMAP3K7" EXACT PRO-short-label [PRO:DNx]
synonym: "TGF-beta-activated kinase 1 (mouse)" EXACT [UniProtKB:Q62073]
synonym: "transforming growth factor-beta-activated kinase 1 (mouse)" EXACT [UniProtKB:Q62073]
xref: UniProtKB:Q62073
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003158 ! mitogen-activated protein kinase kinase kinase 7
relationship: has_gene_template MGI:1346877 ! Map3k7 (mouse)

[Term]
id: PR:O43318-3
name: mitogen-activated protein kinase kinase kinase 7 isoform h1C (human)
def: "A mitogen-activated protein kinase kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43318-3." [PRO:DNx, UniProtKB:O43318]
comment: Category=organism-sequence.
synonym: "hMAP3K7/iso:h1C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43318-3
is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003159
name: mitogen-activated protein kinase kinase kinase 7 isoform 1
def: "A mitogen-activated protein kinase kinase kinase 7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q62073-1 or a 1:1 ortholog thereof." [PMID:8533096]
comment: Category=sequence.
synonym: "MAP3K7/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "TAK1 isoform 1A" EXACT []
is_a: PR:000003158 ! mitogen-activated protein kinase kinase kinase 7

[Term]
id: PR:000003158
name: mitogen-activated protein kinase kinase kinase 7
def: "A protein that is a translation product of the human MAP3K7 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "TAK1" RELATED Gene-based []
synonym: "MAP3K7" EXACT PRO-short-label [PRO:DNx]
synonym: "TGF-beta-activated kinase 1" EXACT []
synonym: "transforming growth factor-beta-activated kinase 1" EXACT []
xref: IUPHARobj:2082
xref: PIRSF:PIRSF038168
is_a: PR:000000001 ! protein

[Term]
id: PR:000003162
name: mitogen-activated protein kinase kinase kinase 7 isoform 1 ubiquitinated 1
def: "A mitogen-activated protein kinase kinase kinase 7 isoform 1 ubiquitinated form that has been modified by XIAP. This leads to proteosomal degradation of mitogen-activated protein kinase kinase kinase 7 isoform 1." [PMID:16157589]
comment: Category=modification.
synonym: "MAP3K7/iso:1/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003161 ! mitogen-activated protein kinase kinase kinase 7 isoform 1 ubiquitinated form

[Term]
id: PR:O43318-1
name: mitogen-activated protein kinase kinase kinase 7 isoform h1B (human)
def: "A mitogen-activated protein kinase kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43318-1." [PRO:DNx, UniProtKB:O43318]
comment: Category=organism-sequence.
synonym: "hMAP3K7/iso:h1B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43318-1
is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43318-2
name: mitogen-activated protein kinase kinase kinase 7 isoform 1A (human)
def: "A mitogen-activated protein kinase kinase kinase 7 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43318]
comment: Category=organism-sequence.
synonym: "hMAP3K7/iso:1A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43318-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003159 ! mitogen-activated protein kinase kinase kinase 7 isoform 1

[Term]
id: PR:000003161
name: mitogen-activated protein kinase kinase kinase 7 isoform 1 ubiquitinated form
def: "A mitogen-activated protein kinase kinase kinase 7 isoform 1 that includes at least one ubiquitinated lysine." [PRO:CNA]
comment: Category=modification.
synonym: "MAP3K7/iso:1/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:000003159 ! mitogen-activated protein kinase kinase kinase 7 isoform 1

[Term]
id: PR:O43318-4
name: mitogen-activated protein kinase kinase kinase 7 isoform h1D (human)
def: "A mitogen-activated protein kinase kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43318-4." [PRO:DNx, UniProtKB:O43318]
comment: Category=organism-sequence.
synonym: "hMAP3K7/iso:h1D" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43318-4
is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q62073-1
name: mitogen-activated protein kinase kinase kinase 7 isoform 1 (mouse)
def: "A mitogen-activated protein kinase kinase kinase 7 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q62073]
comment: Category=organism-sequence.
synonym: "mMAP3K7/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q62073-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003159 ! mitogen-activated protein kinase kinase kinase 7 isoform 1

[Term]
id: PR:000048307
name: mitogen-activated protein kinase kinase kinase 7 phosphorylated 2 (human)
def: "A mitogen-activated protein kinase kinase kinase 7 (human) that has been post-translationally modified to include phosphothreonine at position 187 of the amino acid sequence represented by UniProtKB:O43318. UniProtKB:O43318, Thr-187, MOD:00047." [PRO:DNx, Reactome:R-HSA-1168568, Reactome:R-HSA-206014]
comment: Category=organism-modification.
synonym: "hMAP3K7/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43318, Thr-187, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-206014 "PR:000048307 located_in GO:0005829"
xref: Reactome:R-HSA-1168568 "PR:000048307 located_in GO:0005886"
is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045971
name: mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 (mouse)
def: "A mitogen-activated protein kinase kinase kinase 7 (mouse) that has been phosphorylated at Ser-412. UniProtKB:Q62073, Ser-412, MOD:00046." [PMID:15647289, iPTMnet:Q62073]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15647289). Status=unreviewed.
synonym: "mMAP3K7/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q62073, Ser-412, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q62073 ! mitogen-activated protein kinase kinase kinase 7 (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000048309
name: mitogen-activated protein kinase kinase kinase 7 ubiquitinated 1 (human)
def: "A mitogen-activated protein kinase kinase kinase 7 (human) that has been post-translationally modified to include ubiquitinated lysine at positions 34 and 158 of the amino acid sequence represented by UniProtKB:O43318. UniProtKB:O43318, Lys-34/Lys-158, MOD:01148." [PRO:DNx, Reactome:R-HSA-5607643]
comment: Category=organism-modification.
synonym: "hMAP3K7/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43318, Lys-34/Lys-158, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5607643 "PR:000048309 located_in GO:0005829"
is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048308
name: mitogen-activated protein kinase kinase kinase 7 phosphorylated form (human)
def: "A mitogen-activated protein kinase kinase kinase 7 (human) that includes at least one phosphorylated residue. UniProtKB:O43318, MOD:00696." [PRO:DNx, Reactome:R-HSA-168163]
comment: Category=organism-modification.
synonym: "hMAP3K7/PhosRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43318, MOD:00696" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-168163 "PR:000048308 located_in GO:0005829"
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035736
name: mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 (human)
def: "A mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 in human. UniProtKB:O43318, Thr-184/Thr-187, MOD:00047." [PRO:DNx, UniProtKB:O43318]
comment: Category=organism-modification.
synonym: "hMAP3K7/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-T184,187-TAK1 (human)" EXACT [Reactome:R-HSA-202527, Reactome:R-HSA-450332]
synonym: "UniProtKB:O43318, Thr-184/Thr-187, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202527 "PR:000035736 located_in GO:0005829"
xref: Reactome:R-HSA-450332 "PR:000035736 located_in GO:0010008"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035735 ! mitogen-activated protein kinase kinase kinase 7 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q8RX66
name: serine/threonine-protein kinase Nek3 (Arabidopsis thaliana)
def: "A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of Arabidopsis thaliana." [OMA:Q8RX66, PRO:DNx]
comment: Category=organism-gene.
synonym: "NEK3" RELATED Gene-based [UniProtKB:Q8RX66]
synonym: "AtNek3" EXACT [UniProtKB:Q8RX66]
synonym: "T8M17.60" RELATED Gene-based [UniProtKB:Q8RX66]
synonym: "At-MAP3K7" EXACT PRO-short-label [PRO:DNx]
synonym: "At5g28290" RELATED Gene-based [UniProtKB:Q8RX66]
synonym: "NimA-related protein kinase 3 (Arabidopsis thaliana)" EXACT [UniProtKB:Q8RX66]
xref: UniProtKB:Q8RX66
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000003158 ! mitogen-activated protein kinase kinase kinase 7
relationship: has_gene_template Araport:AT5G28290 ! NEK3 (Arabidopsis thaliana)

[Term]
id: PR:000035735
name: mitogen-activated protein kinase kinase kinase 7 phosphorylated 1
def: "A mitogen-activated protein kinase kinase kinase 7 that has been phosphorylated by autocatalysis on Thr residues within the protein kinase domain. Example: UniProtKB:O43318, Thr-184/Thr-187, MOD:00047." [Reactome:R-HSA-202527, Reactome:R-HSA-450332]
comment: Category=modification.
synonym: "MAP3K7/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "TAK1 phosphorylated" RELATED []
is_a: PR:000003158 ! mitogen-activated protein kinase kinase kinase 7
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000048310
name: mitogen-activated protein kinase kinase kinase 7 ubiquitinated form (human)
def: "A mitogen-activated protein kinase kinase kinase 7 (human) that includes at least one ubiquitinated lysine. UniProtKB:O43318, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782968]
comment: Category=organism-modification.
synonym: "hMAP3K7/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43318, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782968 "PR:000048310 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43318
name: mitogen-activated protein kinase kinase kinase 7 (human)
def: "A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43318]
comment: Category=organism-gene.
synonym: "TAK1" RELATED Gene-based [UniProtKB:O43318]
synonym: "MAP3K7" RELATED Gene-based [UniProtKB:O43318]
synonym: "hMAP3K7" EXACT PRO-short-label [PRO:DNx]
synonym: "TGF-beta-activated kinase 1 (human)" EXACT [UniProtKB:O43318]
synonym: "transforming growth factor-beta-activated kinase 1 (human)" EXACT [UniProtKB:O43318]
xref: Reactome:R-HSA-168156 "PR:O43318 located_in GO:0005829"
xref: Reactome:R-HSA-450315 "PR:O43318 located_in GO:0010008"
xref: Reactome:R-HSA-9012677 "PR:O43318 located_in GO:0005886"
xref: DTO:03100289
xref: UniProtKB:O43318
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003158 ! mitogen-activated protein kinase kinase kinase 7
relationship: has_gene_template HGNC:6859 ! MAP3K7 (human)