[Term]
id: PR:P23188
name: furin (mouse)
def: "A furin that is encoded in the genome of mouse." [OMA:P23188, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fur" RELATED Gene-based [UniProtKB:P23188]
synonym: "Furin" RELATED Gene-based [UniProtKB:P23188]
synonym: "Pcsk3" RELATED Gene-based [UniProtKB:P23188]
synonym: "mFURIN" EXACT PRO-short-label [PRO:DNx]
synonym: "PACE (mouse)" EXACT [UniProtKB:P23188]
synonym: "prohormone convertase 3 (mouse)" RELATED [UniProtKB:P23188]
synonym: "dibasic-processing enzyme (mouse)" EXACT [UniProtKB:P23188]
synonym: "paired basic amino acid residue-cleaving enzyme (mouse)" EXACT [UniProtKB:P23188]
xref: UniProtKB:P23188
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003137 ! furin
relationship: has_gene_template MGI:97513 ! Furin (mouse)

[Term]
id: PR:P09958
name: furin (human)
def: "A furin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P09958]
comment: Category=organism-gene.
synonym: "FUR" RELATED Gene-based [UniProtKB:P09958]
synonym: "PACE" RELATED Gene-based [UniProtKB:P09958]
synonym: "FURIN" RELATED Gene-based [UniProtKB:P09958]
synonym: "PCSK3" RELATED Gene-based [UniProtKB:P09958]
synonym: "hFURIN" EXACT PRO-short-label [PRO:DNx]
synonym: "dibasic-processing enzyme (human)" EXACT [UniProtKB:P09958]
synonym: "paired basic amino acid residue-cleaving enzyme (human)" EXACT [UniProtKB:P09958]
xref: UniProtKB:P09958
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003137 ! furin
relationship: has_gene_template HGNC:8568 ! FURIN (human)

[Term]
id: PR:000003147
name: furin isoform 1
def: "A furin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09958-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "FURIN/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003137 ! furin

[Term]
id: PR:P09958-1
name: furin isoform 1 (human)
def: "A furin isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hFURIN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P09958-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003147 ! furin isoform 1

[Term]
id: PR:000003152
name: furin active form phosphorylated 1
def: "A furin active form phosphorylated form in which the phosphorylation occurs at two Ser residues located in the acid cytoplasmic tail. Phosphorylation of mature furin is required for TGN localization of the endoprotease. Example: UniProtKB:P09958-1, 108-794, Ser-773/Ser-775, MOD:00046." [PMID:8846780, UniProtKB:P09958]
comment: Category=modification.
synonym: "FURIN/active/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "furin mature phosphorylated" EXACT []
is_a: PR:000003151 ! furin active form phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000003151
name: furin active form phosphorylated form
def: "A furin active form that includes at least one phosphorylated residue." [PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "FURIN/active/PhosRes+" EXACT PRO-short-label [PRO:DAN]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000003150 ! furin active form

[Term]
id: PR:000003150
name: furin active form
def: "A furin, signal peptide removed form that has been processed by subsequent removal of the inhibition peptide." [PRO:DAN]
comment: Category=modification.
synonym: "FURIN/active" EXACT PRO-short-label [PRO:DAN]
synonym: "mature furin" EXACT []
intersection_of: PR:000021921 ! furin, signal peptide removed form
intersection_of: lacks_part SO:0001062 ! propeptide

[Term]
id: PR:000018787
name: furin proteolytic cleavage product
def: "A furin that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "FURIN/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000003137 ! furin

[Term]
id: PR:P23188-1
name: furin isoform 1 (mouse)
def: "A furin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mFURIN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23188-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003147 ! furin isoform 1

[Term]
id: PR:P23377
name: furin (rat)
def: "A furin that is encoded in the genome of rat." [PANTHER:PTHR10795:SF16, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fur" RELATED Gene-based [UniProtKB:P23377]
synonym: "Furin" RELATED Gene-based [UniProtKB:P23377]
synonym: "Pcsk3" RELATED Gene-based [UniProtKB:P23377]
synonym: "rFURIN" EXACT PRO-short-label [PRO:DNx]
synonym: "PACE (rat)" EXACT [UniProtKB:P23377]
synonym: "prohormone convertase 3 (rat)" RELATED [UniProtKB:P23377]
synonym: "dibasic-processing enzyme (rat)" EXACT [UniProtKB:P23377]
synonym: "paired basic amino acid residue-cleaving enzyme (rat)" EXACT [UniProtKB:P23377]
xref: UniProtKB:P23377
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003137 ! furin
relationship: has_gene_template RGD:3274 ! Furin (rat)

[Term]
id: PR:000035903
name: furin active form (human)
def: "A furin active form in human. UniProtKB:P09958, 108-794." [PMID:1629222, Reactome:R-HSA-1181103, Reactome:R-HSA-157049, Reactome:R-HSA-2159856, Reactome:R-HSA-448351]
comment: Category=organism-modification.
synonym: "hFURIN/active" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000027029" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P09958, 108-794" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-157049 "PR:000035903 located_in GO:0000139"
xref: Reactome:R-HSA-448351 "PR:000035903 located_in GO:0005796"
xref: Reactome:R-HSA-1181103 "PR:000035903 located_in GO:0005576"
xref: Reactome:R-HSA-2159856 "PR:000035903 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003150 ! furin active form

[Term]
id: PR:000021921
name: furin, signal peptide removed form
def: "A furin that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "FURIN/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003137 ! furin
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:O17798
name: furin-like protease kpc-1 (worm)
def: "A furin that is encoded in the genome of worm." [OMA:O17798, PRO:CNA]
comment: Category=organism-gene.
synonym: "kpc-1" RELATED Gene-based [UniProtKB:O17798]
synonym: "F11A6.1" RELATED Gene-based [UniProtKB:O17798]
synonym: "FURIN (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "CelfurPC protein" EXACT [UniProtKB:O17798]
xref: UniProtKB:O17798
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000003137 ! furin
relationship: has_gene_template WormBase:WBGene00002232 ! kpc-1 (worm)

[Term]
id: PR:000003137
name: furin
def: "A subtilisin/kexin-type proprotein convertase that is a translation product of the human FURIN gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "FUR" RELATED Gene-based []
synonym: "PACE" RELATED Gene-based []
synonym: "FURIN" EXACT PRO-short-label [PRO:DNx]
synonym: "PCSK3" RELATED Gene-based []
synonym: "prohormone convertase 3" RELATED []
synonym: "dibasic-processing enzyme" EXACT []
synonym: "paired basic amino acid residue-cleaving enzyme" EXACT []
xref: IUPHARobj:2366
is_a: PR:000003136 ! subtilisin/kexin-type proprotein convertase