[Term]
id: PR:P46527-1
name: cyclin-dependent kinase inhibitor 1B isoform 1 (human)
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCDKN1B/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46527-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003091 ! cyclin-dependent kinase inhibitor 1B isoform 1

[Term]
id: PR:000003094
name: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated form in which the phosphorylation occurs within the nuclear localization sequence (NLS)." [PMID:15057270, PRO:JAN]
comment: Category=modification. Note: Phosphorylation can occur at Ser and/or Thr residues.
synonym: "p27NLS" EXACT []
synonym: "CDKN1B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p27 phosphorylated form" RELATED []
is_a: PR:000003093 ! cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated form
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000025749
name: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated form in which the phosphorylation occurs at a conserved Tyr residue that is major phosphoacceptor site in the Cdk-binding domain. Example: UniProtKB:P46527-1, Tyr-88, MOD:00048." [PMID:17254966, PRO:DAN, PRO:JAN]
comment: Category=modification.
synonym: "CDKN1B/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "p27 phosphorylated form" RELATED []
is_a: PR:000003093 ! cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000003092
name: cyclin-dependent kinase inhibitor 1B isoform 1 unmodified form
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:JAN]
comment: Category=modification.
synonym: "CDKN1B/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003091 ! cyclin-dependent kinase inhibitor 1B isoform 1
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:000003093
name: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated form
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "CDKN1B/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000003091 ! cyclin-dependent kinase inhibitor 1B isoform 1

[Term]
id: PR:000003090
name: cyclin-dependent kinase inhibitor 1B
def: "A protein that is a translation product of the human CDKN1B gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "KIP1" RELATED Gene-based []
synonym: "CDKN1B" EXACT PRO-short-label [PRO:DNx]
synonym: "p27Kip1" EXACT []
synonym: "cyclin-dependent kinase inhibitor p27" EXACT []
xref: PIRSF:PIRSF018555
is_a: PR:000000001 ! protein

[Term]
id: PR:000003091
name: cyclin-dependent kinase inhibitor 1B isoform 1
def: "A cyclin-dependent kinase inhibitor 1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46527-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "CDKN1B/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003090 ! cyclin-dependent kinase inhibitor 1B

[Term]
id: PR:000025752
name: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 (human)
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 in human. UniProtKB:P46527-1, Tyr-88, MOD:00048|Thr-187, MOD:00047." [PMID:17254966, PRO:CNA]
comment: Category=organism-modification.
synonym: "hCDKN1B/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46527-1, Tyr-88, MOD:00048|Thr-187, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025751 ! cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P46414
name: cyclin-dependent kinase inhibitor 1B (mouse)
def: "A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of mouse." [OMA:P46414, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cdkn1b" RELATED Gene-based [UniProtKB:P46414]
synonym: "mCDKN1B" EXACT PRO-short-label [PRO:DNx]
synonym: "p27Kip1 (mouse)" EXACT [UniProtKB:P46414]
synonym: "cyclin-dependent kinase inhibitor p27 (mouse)" EXACT [UniProtKB:P46414]
xref: UniProtKB:P46414
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003090 ! cyclin-dependent kinase inhibitor 1B
relationship: has_gene_template MGI:104565 ! Cdkn1b (mouse)

[Term]
id: PR:000046682
name: cyclin-dependent kinase inhibitor 1B phosphorylated 4 (human)
def: "A cyclin-dependent kinase inhibitor 1B (human) that has been post-translationally modified to include phosphothreonine at position 187 of the amino acid sequence represented by UniProtKB:P46527. UniProtKB:P46527, Thr-187, MOD:00047." [PRO:DNx, Reactome:R-HSA-187525]
comment: Category=organism-modification.
synonym: "hCDKN1B/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46527, Thr-187, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-187525 "PR:000046682 located_in GO:0005654"
is_a: PR:P46527 ! cyclin-dependent kinase inhibitor 1B (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P46527
name: cyclin-dependent kinase inhibitor 1B (human)
def: "A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P46527]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "KIP1" RELATED Gene-based [UniProtKB:P46527]
synonym: "CDKN1B" RELATED Gene-based [UniProtKB:P46527]
synonym: "hCDKN1B" EXACT PRO-short-label [PRO:DNx]
synonym: "p27Kip1 (human)" EXACT [UniProtKB:P46527]
synonym: "cyclin-dependent kinase inhibitor p27 (human)" EXACT [UniProtKB:P46527]
xref: UniProtKB:P46527
xref: Reactome:R-HSA-182563 "PR:P46527 located_in GO:0005654"
xref: Reactome:R-HSA-198622 "PR:P46527 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003090 ! cyclin-dependent kinase inhibitor 1B
relationship: has_gene_template HGNC:1785 ! CDKN1B (human)

[Term]
id: PR:000036634
name: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 (human)
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 in human. UniProtKB:P46527-1, Thr-157, MOD:00047." [PMID:12244301, PMID:15057270, PRO:JAN]
comment: Category=organism-modification.
synonym: "hCDKN1B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46527-1, Thr-157, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000003094 ! cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046683
name: cyclin-dependent kinase inhibitor 1B phosphorylated 2 (human)
def: "A cyclin-dependent kinase inhibitor 1B (human) that has been post-translationally modified to include phosphotyrosine at position 88 of the amino acid sequence represented by UniProtKB:P46527. UniProtKB:P46527, Tyr-88, MOD:00048." [PRO:DNx, Reactome:R-HSA-8848438]
comment: Category=organism-modification.
synonym: "hCDKN1B/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46527, Tyr-88, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8848438 "PR:000046683 located_in GO:0005829"
xref: Reactome:R-HSA-8942808 "PR:000046683 located_in GO:0005654"
is_a: PR:P46527 ! cyclin-dependent kinase inhibitor 1B (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025751
name: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated form in which the phosphorylation occurs at a conserved Tyr residue that is major phosphoacceptor site in the Cdk-binding domain, and phosphorylated by CDK2 on a Thr residue in the C-terminal region. Phosphorylation by CDK2 promotes degradation by the SCF-Skp2 ubiquitin-proteasome pathway. Example: UniProtKB:P46527-1, Tyr-88, MOD:00048|Thr-187, MOD:00047." [PMID:17254966, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "CDKN1B/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "p27 phosphorylated form" RELATED []
is_a: PR:000003093 ! cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000045370
name: cyclin-dependent kinase inhibitor 1B isoform 1 unphosphorylated 2 (human)
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 (human) that lacks phosphorylation at Tyr-88. UniProtKB:P46527-1, Tyr-88, PR:000026291." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hCDKN1B/iso:1/UnPhos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46527-1, Tyr-88, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P46527-1 ! cyclin-dependent kinase inhibitor 1B isoform 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045790
name: cyclin-dependent kinase inhibitor 1B phosphorylated 1 (human)
def: "A cyclin-dependent kinase inhibitor 1B (human) that has been phosphorylated at Thr-198. UniProtKB:P46527, Thr-198, MOD:00047." [PMID:15280662, iPTMnet:P46527]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15280662). Status=unreviewed.
synonym: "hCDKN1B/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46527, Thr-198, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P46527 ! cyclin-dependent kinase inhibitor 1B (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P46414-1
name: cyclin-dependent kinase inhibitor 1B isoform 1 (mouse)
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCDKN1B/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46414-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003091 ! cyclin-dependent kinase inhibitor 1B isoform 1

[Term]
id: PR:000046182
name: cyclin-dependent kinase inhibitor 1B phosphorylated 1 (mouse)
def: "A cyclin-dependent kinase inhibitor 1B (mouse) that has been phosphorylated at Ser-10. UniProtKB:P46414, Ser-10, MOD:00046." [PMID:15010468, iPTMnet:P46414]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15010468). Status=unreviewed.
synonym: "mCDKN1B/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46414, Ser-10, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P46414 ! cyclin-dependent kinase inhibitor 1B (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000025750
name: cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)
def: "A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 in human. Phosphorylation at this site promotes subsequent Cdk2-mediated phosphorylation at Thr-187. UniProtKB:P46527-1, Tyr-88, MOD:00048." [PMID:17254966, PRO:JAN]
comment: Category=organism-modification.
synonym: "hCDKN1B/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46527-1, Tyr-88, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025749 ! cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine