[Term]
id: PR:000049800
name: tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at positions 519 and 520, but it is still phosphorylated at Tyr 342 and 346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291." [PMID:27609517, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27609517).
synonym: "mSYK/iso:1/Phos:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P48025-1 ! tyrosine-protein kinase SYK isoform 1 (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049392
name: tyrosine-protein kinase SYK phosphotyrosine form (human)
def: "A tyrosine-protein kinase SYK (human) that includes at least one phosphorylated tyrosine. UniProtKB:P43405, MOD:00048." [PRO:DNx, Reactome:R-HSA-429432]
comment: Category=organism-modification.
synonym: "hSYK/PhosTyr+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43405, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-429432 "PR:000049392 located_in GO:0005886"
intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine
intersection_of: PR:P43405 ! tyrosine-protein kinase SYK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049391
name: tyrosine-protein kinase SYK phosphorylated 3 (human)
def: "A tyrosine-protein kinase SYK (human) that has been post-translationally modified to include phosphotyrosine at positions 131, 323, 348, 352, 525 and 526 of the amino acid sequence represented by UniProtKB:P43405. UniProtKB:P43405, Tyr-131/Tyr-323/Tyr-348/Tyr-352/Tyr-525/Tyr-526, MOD:00048." [PRO:DNx, Reactome:R-HSA-1861712, Reactome:R-HSA-983586]
comment: Category=organism-modification.
synonym: "hSYK/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43405, Tyr-131/Tyr-323/Tyr-348/Tyr-352/Tyr-525/Tyr-526, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-983586 "PR:000049391 located_in GO:0005886"
xref: Reactome:R-HSA-1861712 "PR:000049391 located_in GO:0005829"
is_a: PR:P43405 ! tyrosine-protein kinase SYK (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049793
name: tyrosine-protein kinase SYK isoform 1 phosphorylated 3 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-346. UniProtKB:P48025-1, Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27609517).
synonym: "mSYK/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "mSYK long isoform Y346 phosphorylated" EXACT []
synonym: "UniProtKB:P48025-1, Tyr-346, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P48025-1 ! tyrosine-protein kinase SYK isoform 1 (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000026193
name: tyrosine-protein kinase SYK phosphorylated 2
def: "A tyrosine-protein kinase SYK that has been phosphorylated on a Tyr residue by autocatalysis. Example: UniProtKB:P43405-1, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]
comment: Category=modification.
synonym: "SYK/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003065 ! tyrosine-protein kinase SYK
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q64725
name: tyrosine-protein kinase SYK (rat)
def: "A tyrosine-protein kinase SYK that is encoded in the genome of rat." [PANTHER:PTHR24418:SF99, PRO:DNx]
comment: Category=organism-gene.
synonym: "Syk" RELATED Gene-based [UniProtKB:Q64725]
synonym: "rSYK" EXACT PRO-short-label [PRO:DNx]
synonym: "p72Syk (rat)" EXACT [UniProtKB:Q64725]
synonym: "spleen tyrosine kinase (rat)" EXACT [UniProtKB:Q64725]
xref: UniProtKB:Q64725
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003065 ! tyrosine-protein kinase SYK
relationship: has_gene_template RGD:3796 ! Syk (rat)

[Term]
id: PR:000049792
name: tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 342. UniProtKB:P48025-1, Tyr-342, PR:000026291." [PMID:27609517, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27609517).
synonym: "mSYK/iso:1/UnPhos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P48025-1, Tyr-342, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P48025-1 ! tyrosine-protein kinase SYK isoform 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049791
name: tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342. UniProtKB:P48025-1, Tyr-342, MOD:00048." [PMID:27609517, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27609517).
synonym: "mSYK/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "mSYK long isoform Y342 phosphorylated" EXACT []
synonym: "UniProtKB:P48025-1, Tyr-342, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P48025-1 ! tyrosine-protein kinase SYK isoform 1 (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049796
name: tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342, Tyr-346, Tyr-519 and Tyr-520. UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048." [PMID:27609517, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27609517).
synonym: "mSYK/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "mSYK long isoform Y342/Y346/Y519/Y520 phosphorylated" EXACT []
synonym: "UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P48025-1 ! tyrosine-protein kinase SYK isoform 1 (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049795
name: tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342 and Tyr-346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048." [PMID:27609517, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27609517).
synonym: "mSYK/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "mSYK long isoform Y342/Y346 phosphorylated" EXACT []
synonym: "UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P48025-1 ! tyrosine-protein kinase SYK isoform 1 (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049794
name: tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 346. UniProtKB:P48025-1, Tyr-346, PR:000026291." [PMID:27609517, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27609517). Note: Dephosphorylated by Ubash3b (Tula-2).
synonym: "mSYK/iso:1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P48025-1, Tyr-346, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P48025-1 ! tyrosine-protein kinase SYK isoform 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q64725-1
name: tyrosine-protein kinase SYK isoform SykB (rat)
def: "A tyrosine-protein kinase SYK (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64725-1." [PRO:DNx, UniProtKB:Q64725]
comment: Category=organism-sequence.
synonym: "rSYK/iso:SykB" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q64725-1
is_a: PR:Q64725 ! tyrosine-protein kinase SYK (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q64725-2
name: tyrosine-protein kinase SYK isoform SykA (rat)
def: "A tyrosine-protein kinase SYK (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64725-2." [PRO:DNx, UniProtKB:Q64725]
comment: Category=organism-sequence.
synonym: "rSYK/iso:SykA" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q64725-2
is_a: PR:Q64725 ! tyrosine-protein kinase SYK (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P43405-1
name: tyrosine-protein kinase SYK isoform Long (human)
def: "A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hSYK/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43405-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025832 ! tyrosine-protein kinase SYK isoform 1

[Term]
id: PR:P43405-2
name: tyrosine-protein kinase SYK isoform Short (human)
def: "A tyrosine-protein kinase SYK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43405-2." [PRO:DNx, UniProtKB:P43405]
comment: Category=organism-sequence.
synonym: "hSYK/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43405-2
is_a: PR:P43405 ! tyrosine-protein kinase SYK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:F1N9Y5
name: tyrosine-protein kinase SYK (chicken)
def: "A tyrosine-protein kinase SYK that is encoded in the genome of chicken." [OMA:F1N9Y5, PRO:DNx]
comment: Category=organism-gene.
synonym: "SYK" RELATED Gene-based [UniProtKB:F1N9Y5]
synonym: "chick-SYK" EXACT PRO-short-label [PRO:DNx]
synonym: "RCJMB04_19o18" RELATED Gene-based [UniProtKB:F1N9Y5]
xref: UniProtKB:F1N9Y5
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000003065 ! tyrosine-protein kinase SYK
relationship: has_gene_template NCBIGene:427272 ! SYK (chicken)

[Term]
id: PR:P43405
name: tyrosine-protein kinase SYK (human)
def: "A tyrosine-protein kinase SYK that is encoded in the genome of human." [PRO:CNA, UniProtKB:P43405]
comment: Category=organism-gene.
synonym: "SYK" RELATED Gene-based [UniProtKB:P43405]
synonym: "hSYK" EXACT PRO-short-label [PRO:DNx]
synonym: "p72-Syk (human)" EXACT [UniProtKB:P43405]
synonym: "spleen tyrosine kinase (human)" EXACT [UniProtKB:P43405]
xref: Reactome:R-HSA-58268 "PR:P43405 located_in GO:0005829"
xref: DTO:03100262
xref: UniProtKB:P43405
xref: Reactome:R-HSA-139844 "PR:P43405 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003065 ! tyrosine-protein kinase SYK
relationship: has_gene_template HGNC:11491 ! SYK (human)

[Term]
id: PR:000025832
name: tyrosine-protein kinase SYK isoform 1
def: "A tyrosine-protein kinase SYK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48025-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "SYK/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003065 ! tyrosine-protein kinase SYK

[Term]
id: PR:000025833
name: tyrosine-protein kinase SYK isoform 1 phosphorylated 1
def: "A tyrosine-protein kinase SYK isoform 1 that has been phosphorylated on several Tyr residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lyn. Example: UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "SYK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000025832 ! tyrosine-protein kinase SYK isoform 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000025834
name: tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]
comment: Category=organism-modification.
synonym: "mSYK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025833 ! tyrosine-protein kinase SYK isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000026221
name: tyrosine-protein kinase SYK phosphorylated 2 (human)
def: "A tyrosine-protein kinase SYK phosphorylated 2 in human. UniProtKB:P43405, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]
comment: Category=organism-modification.
synonym: "hSYK/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43405, Tyr-348, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-437953 "PR:000026221 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026193 ! tyrosine-protein kinase SYK phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000003065
name: tyrosine-protein kinase SYK
def: "A SYK/ZAP-70 family tyrosine-protein kinase that is a translation product of the human SYK gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "SYK" EXACT PRO-short-label [PRO:DNx]
synonym: "spleen tyrosine kinase" EXACT []
xref: IUPHARobj:2230
is_a: PR:000003063 ! SYK/ZAP-70 family tyrosine-protein kinase

[Term]
id: PR:P48025-1
name: tyrosine-protein kinase SYK isoform 1 (mouse)
def: "A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSYK/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48025-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025832 ! tyrosine-protein kinase SYK isoform 1

[Term]
id: PR:P48025
name: tyrosine-protein kinase SYK (mouse)
def: "A tyrosine-protein kinase SYK that is encoded in the genome of mouse." [OMA:P48025, PRO:DNx]
comment: Category=organism-gene.
synonym: "Syk" RELATED Gene-based [UniProtKB:P48025]
synonym: "Sykb" RELATED Gene-based [UniProtKB:P48025]
synonym: "mSYK" EXACT PRO-short-label [PRO:DNx]
synonym: "ptk72" RELATED Gene-based [UniProtKB:P48025]
synonym: "spleen tyrosine kinase (mouse)" EXACT [UniProtKB:P48025]
xref: UniProtKB:P48025
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003065 ! tyrosine-protein kinase SYK
relationship: has_gene_template MGI:99515 ! Syk (mouse)