[Term]
id: PR:000003059
name: protein kinase C beta type
def: "A conventional protein kinase C that is a translation product of the human PRKCB gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "PKCB" RELATED Gene-based []
synonym: "PKC-B" EXACT []
synonym: "PRKCB" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKCB1" RELATED Gene-based []
synonym: "PKC-beta" EXACT []
xref: IUPHARobj:1483
is_a: PR:000003057 ! conventional protein kinase C

[Term]
id: PR:P05771-1
name: protein kinase C beta type isoform Beta-I (human)
def: "A protein kinase C beta type isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPRKCB/iso:Beta-I" EXACT PRO-short-label [PRO:DNx]
synonym: "protein kinase C beta type isoform PRKCB1 (human)" EXACT [UniProtKB:P05771]
xref: UniProtKB:P05771-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038682 ! protein kinase C beta type isoform 1

[Term]
id: PR:P05771-2
name: protein kinase C beta type isoform Beta-II (human)
def: "A protein kinase C beta type isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPRKCB/iso:Beta-II" EXACT PRO-short-label [PRO:DNx]
synonym: "protein kinase C beta type isoform PRKCB2 (human)" EXACT [UniProtKB:P05771]
xref: UniProtKB:P05771-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038683 ! protein kinase C beta type isoform 2

[Term]
id: PR:000049856
name: protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)
def: "A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500,a phosphothreonine at position 641 and a phosphoserine at position 660. UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291." [PMID:8749392, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:8749392).
synonym: "hPRKCB/iso:Beta-II/InitMet-/UnPhos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05771-2 ! protein kinase C beta type isoform Beta-II (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P05771
name: protein kinase C beta type (human)
def: "A protein kinase C beta type that is encoded in the genome of human." [PRO:CNA, UniProtKB:P05771]
comment: Category=organism-gene.
synonym: "PKCB" RELATED Gene-based [UniProtKB:P05771]
synonym: "PRKCB" RELATED Gene-based [UniProtKB:P05771]
synonym: "PRKCB1" RELATED Gene-based [UniProtKB:P05771]
synonym: "hPRKCB" EXACT PRO-short-label [PRO:DNx]
synonym: "PKC-B (human)" EXACT [UniProtKB:P05771]
synonym: "PKC-beta (human)" EXACT [UniProtKB:P05771]
xref: DTO:03100237
xref: UniProtKB:P05771
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003059 ! protein kinase C beta type
relationship: has_gene_template HGNC:9395 ! PRKCB (human)

[Term]
id: PR:000049887
name: protein kinase C beta type phosphorylated 1 (human)
def: "A protein kinase C beta type phosphorylated 1 in human. UniProtKB:P05771, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:8749392).
synonym: "hPRKCB/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05771, Thr-500, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P05771-1, Thr-500, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P05771-2, Thr-500, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000049888 ! protein kinase C beta type phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000048913
name: protein kinase C beta type, initiator methionine removed form (human)
def: "A protein kinase C beta type (human) that has had the initiator methionine removed. UniProtKB:P05771, 2-671." [PRO:DNx, Reactome:R-HSA-156467, Reactome:R-HSA-58198]
comment: Category=organism-modification.
synonym: "PRO_0000055684" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPRKCB/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05771, 2-671" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-58198 "PR:000048913 located_in GO:0005829"
xref: Reactome:R-HSA-156467 "PR:000048913 located_in GO:0005886"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P05771 ! protein kinase C beta type (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049853
name: protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)
def: "A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:8749392).
synonym: "hPRKCB/iso:Beta-II/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05771-2 ! protein kinase C beta type isoform Beta-II (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000049854
name: protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)
def: "A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and lacks a phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291." [PMID:8749392, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:8749392).
synonym: "hPRKCB/iso:Beta-II/InitMet-/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05771-2 ! protein kinase C beta type isoform Beta-II (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000049855
name: protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)
def: "A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:8749392). Kinase=("PRKCB"; PR:P05771; Thr-641/Ser-660).
synonym: "hPRKCB/iso:Beta-II/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05771-2 ! protein kinase C beta type isoform Beta-II (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048914
name: protein kinase C beta type, initiator methionine removed phosphorylated 1 (human)
def: "A protein kinase C beta type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the amino acid sequence represented by UniProtKB:P05771. UniProtKB:P05771, 2-671, Thr-500, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218728]
comment: Category=organism-modification.
synonym: "hPRKCB/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055684, Thr-500, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P05771, 2-671, Thr-500, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218728 "PR:000048914 located_in GO:0005829"
is_a: PR:P05771 ! protein kinase C beta type (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048915
name: protein kinase C beta type, initiator methionine removed phosphorylated 2 (human)
def: "A protein kinase C beta type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 500 and 642, and phosphoserine at position 661 of the amino acid sequence represented by UniProtKB:P05771. UniProtKB:P05771, 2-671, Thr-500/Thr-642, MOD:00047|Ser-661, MOD:00046." [PRO:DNx, Reactome:R-HSA-5218706, Reactome:R-HSA-5223294]
comment: Category=organism-modification.
synonym: "hPRKCB/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055684, Thr-500/Thr-642, MOD:00047|Ser-661, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P05771, 2-671, Thr-500/Thr-642, MOD:00047|Ser-661, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218706 "PR:000048915 located_in GO:0005829"
xref: Reactome:R-HSA-5223294 "PR:000048915 located_in GO:0005654"
is_a: PR:P05771 ! protein kinase C beta type (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine