[Term]
id: PR:000003058
name: protein kinase C alpha type
def: "A conventional protein kinase C that is a translation product of the human PRKCA gene or a 1:1 ortholog thereof." [PRO:CL]
comment: Category=gene.
synonym: "PKCA" RELATED Gene-based []
synonym: "PKC-A" EXACT []
synonym: "PRKCA" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKACA" RELATED Gene-based []
synonym: "PKC-alpha" EXACT []
synonym: "protein kinase Calpha" EXACT [PMID:9648724]
xref: IUPHARobj:1482
is_a: PR:000003057 ! conventional protein kinase C

[Term]
id: PR:P17252-1
name: protein kinase C alpha type isoform 1 (human)
def: "A protein kinase C alpha type isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPRKCA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P17252-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038974 ! protein kinase C alpha type isoform 1

[Term]
id: PR:P17252
name: protein kinase C alpha type (human)
def: "A protein kinase C alpha type that is encoded in the genome of human." [PRO:CL, UniProtKB:P17252]
comment: Category=organism-gene.
synonym: "PKCA" RELATED Gene-based [UniProtKB:P17252]
synonym: "PRKCA" RELATED Gene-based [UniProtKB:P17252]
synonym: "PRKACA" RELATED Gene-based [UniProtKB:P17252]
synonym: "hPRKCA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKC-A (human)" EXACT [UniProtKB:P17252]
synonym: "PKC-alpha (human)" EXACT [UniProtKB:P17252]
xref: DTO:03100236
xref: UniProtKB:P17252
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003058 ! protein kinase C alpha type
relationship: has_gene_template HGNC:9393 ! PRKCA (human)

[Term]
id: PR:000048912
name: protein kinase C alpha type, initiator methionine removed phosphorylated 2 (human)
def: "A protein kinase C alpha type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 497 and 638, and phosphoserine at position 657 of the amino acid sequence represented by UniProtKB:P17252. UniProtKB:P17252, 2-672, Thr-497/Thr-638, MOD:00047|Ser-657, MOD:00046." [PRO:DNx, Reactome:R-HSA-4332337, Reactome:R-HSA-4332340, Reactome:R-HSA-5223292]
comment: Category=organism-modification.
synonym: "hPRKCA/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055679, Thr-497/Thr-638, MOD:00047|Ser-657, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P17252, 2-672, Thr-497/Thr-638, MOD:00047|Ser-657, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4332337 "PR:000048912 located_in GO:0005829"
xref: Reactome:R-HSA-4332340 "PR:000048912 located_in GO:0005886"
xref: Reactome:R-HSA-5223292 "PR:000048912 located_in GO:0005654"
is_a: PR:P17252 ! protein kinase C alpha type (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048910
name: protein kinase C alpha type, initiator methionine removed form (human)
def: "A protein kinase C alpha type (human) that has had the initiator methionine removed. UniProtKB:P17252, 2-672." [PRO:DNx, Reactome:R-HSA-156469, Reactome:R-HSA-2648987, Reactome:R-HSA-450530, Reactome:R-HSA-58196]
comment: Category=organism-modification.
synonym: "PRO_0000055679" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPRKCA/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17252, 2-672" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-58196 "PR:000048910 located_in GO:0005829"
xref: Reactome:R-HSA-156469 "PR:000048910 located_in GO:0005886"
xref: Reactome:R-HSA-450530 "PR:000048910 located_in GO:0005654"
xref: Reactome:R-HSA-2648987 "PR:000048910 located_in GO:0097381"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P17252 ! protein kinase C alpha type (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048911
name: protein kinase C alpha type, initiator methionine removed phosphorylated 1 (human)
def: "A protein kinase C alpha type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 497 of the amino acid sequence represented by UniProtKB:P17252. UniProtKB:P17252, 2-672, Thr-497, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218731]
comment: Category=organism-modification.
synonym: "hPRKCA/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055679, Thr-497, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P17252, 2-672, Thr-497, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218731 "PR:000048911 located_in GO:0005829"
is_a: PR:P17252 ! protein kinase C alpha type (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine