[Term]
id: PR:000003044
name: mitogen-activated protein kinase kinase kinase kinase 4 isoform 1
def: "A mitogen-activated protein kinase kinase kinase kinase 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97820-1 or a 1:1 ortholog thereof." [PMID:9135144, PRO:AL]
comment: Category=sequence.
synonym: "MAP4K4/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003043 ! mitogen-activated protein kinase kinase kinase kinase 4

[Term]
id: PR:000003043
name: mitogen-activated protein kinase kinase kinase kinase 4
def: "A protein that is a translation product of the human MAP4K4 gene or a 1:1 ortholog thereof." [PMID:16938849, PRO:AL]
comment: Category=gene.
synonym: "HGK" RELATED Gene-based []
synonym: "NIK" RELATED Gene-based []
synonym: "MAP4K4" EXACT PRO-short-label [PRO:DNx]
synonym: "MEKKK 4" EXACT []
synonym: "KIAA0687" RELATED Gene-based []
synonym: "MEK kinase kinase 4" EXACT []
synonym: "Nck-interacting kinase" EXACT []
synonym: "HPK/GCK-like kinase HGK" EXACT []
synonym: "MAPK/ERK kinase kinase kinase 4" EXACT []
xref: IUPHARobj:2088
is_a: PR:000000001 ! protein

[Term]
id: PR:P97820-1
name: mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 (mouse)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:AL]
comment: Category=organism-sequence.
synonym: "mMAP4K4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P97820-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003044 ! mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

[Term]
id: PR:Q23356-4
name: serine/threonine-protein kinase mig-15 isoform d (worm)
def: "A serine/threonine-protein kinase mig-15 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q23356-4." [PRO:DNx, UniProtKB:Q23356]
comment: Category=organism-sequence.
synonym: "MAP4K4/iso:d (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q23356-4
is_a: PR:Q23356 ! serine/threonine-protein kinase mig-15 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q0WPH8
name: serine/threonine-protein kinase Nek5 (Arabidopsis thaliana)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of Arabidopsis thaliana." [PRO:AL]
comment: Category=organism-gene.
synonym: "NEK5" RELATED Gene-based [UniProtKB:Q0WPH8]
synonym: "NEK6" RELATED Gene-based [UniProtKB:Q0WPH8]
synonym: "AtNEK6" EXACT [UniProtKB:Q0WPH8]
synonym: "AtNek5" EXACT [UniProtKB:Q0WPH8]
synonym: "At-MAP4K4" EXACT PRO-short-label [PRO:DNx]
synonym: "At3g44200" RELATED Gene-based [UniProtKB:Q0WPH8]
synonym: "F26G5.150" RELATED Gene-based [UniProtKB:Q0WPH8]
synonym: "NimA-related protein kinase 5 (Arabidopsis thaliana)" EXACT [UniProtKB:Q0WPH8]
xref: UniProtKB:Q0WPH8
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000003043 ! mitogen-activated protein kinase kinase kinase kinase 4
relationship: has_gene_template Araport:AT3G44200 ! NEK5 (Arabidopsis thaliana)

[Term]
id: PR:Q23356-2
name: serine/threonine-protein kinase mig-15 isoform a (worm)
def: "A serine/threonine-protein kinase mig-15 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q23356-2." [PRO:DNx, UniProtKB:Q23356]
comment: Category=organism-sequence.
synonym: "MAP4K4/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q23356-2
is_a: PR:Q23356 ! serine/threonine-protein kinase mig-15 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q23356-3
name: serine/threonine-protein kinase mig-15 isoform b (worm)
def: "A serine/threonine-protein kinase mig-15 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q23356-3." [PRO:DNx, UniProtKB:Q23356]
comment: Category=organism-sequence.
synonym: "MAP4K4/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q23356-3
is_a: PR:Q23356 ! serine/threonine-protein kinase mig-15 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:P97820
name: mitogen-activated protein kinase kinase kinase kinase 4 (mouse)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of mouse." [OMA:P97820, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nik" RELATED Gene-based [UniProtKB:P97820]
synonym: "Map4k4" RELATED Gene-based [UniProtKB:P97820]
synonym: "mMAP4K4" EXACT PRO-short-label [PRO:DNx]
synonym: "MEKKK 4 (mouse)" EXACT [UniProtKB:P97820]
synonym: "MEK kinase kinase 4 (mouse)" EXACT [UniProtKB:P97820]
synonym: "Nck-interacting kinase (mouse)" EXACT [UniProtKB:P97820]
synonym: "HPK/GCK-like kinase HGK (mouse)" EXACT [UniProtKB:P97820]
synonym: "MAPK/ERK kinase kinase kinase 4 (mouse)" EXACT [UniProtKB:P97820]
xref: UniProtKB:P97820
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003043 ! mitogen-activated protein kinase kinase kinase kinase 4
relationship: has_gene_template MGI:1349394 ! Map4k4 (mouse)

[Term]
id: PR:O95819-5
name: mitogen-activated protein kinase kinase kinase kinase 4 isoform h5 (human)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-5." [PRO:DNx, UniProtKB:O95819]
comment: Category=organism-sequence.
synonym: "hMAP4K4/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "mitogen-activated protein kinase kinase kinase kinase 4 isoform HGK-L (human)" EXACT [UniProtKB:O95819]
xref: UniProtKB:O95819-5
is_a: PR:O95819 ! mitogen-activated protein kinase kinase kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95819-4
name: mitogen-activated protein kinase kinase kinase kinase 4 isoform h4 (human)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-4." [PRO:DNx, UniProtKB:O95819]
comment: Category=organism-sequence.
synonym: "hMAP4K4/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "mitogen-activated protein kinase kinase kinase kinase 4 isoform HGK-S (human)" EXACT [UniProtKB:O95819]
xref: UniProtKB:O95819-4
is_a: PR:O95819 ! mitogen-activated protein kinase kinase kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q23356
name: serine/threonine-protein kinase mig-15 (worm)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of worm." [OMA:Q23356, PRO:DAN]
comment: Category=organism-gene.
synonym: "mig-15" RELATED Gene-based [UniProtKB:Q23356]
synonym: "ZC504.4" RELATED Gene-based [UniProtKB:Q23356]
synonym: "MAP4K4 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "abnormal cell migration protein 15 (worm)" EXACT [UniProtKB:Q23356]
xref: UniProtKB:Q23356
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000003043 ! mitogen-activated protein kinase kinase kinase kinase 4
relationship: has_gene_template WormBase:WBGene00003247 ! mig-15 (worm)

[Term]
id: PR:O95819-6
name: mitogen-activated protein kinase kinase kinase kinase 4 isoform h6 (human)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-6." [PRO:DNx, UniProtKB:O95819]
comment: Category=organism-sequence.
synonym: "hMAP4K4/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O95819-6
is_a: PR:O95819 ! mitogen-activated protein kinase kinase kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95819
name: mitogen-activated protein kinase kinase kinase kinase 4 (human)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human." [PRO:AL, UniProtKB:O95819]
comment: Category=organism-gene.
synonym: "HGK" RELATED Gene-based [UniProtKB:O95819]
synonym: "NIK" RELATED Gene-based [UniProtKB:O95819]
synonym: "MAP4K4" RELATED Gene-based [UniProtKB:O95819]
synonym: "hMAP4K4" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0687" RELATED Gene-based [UniProtKB:O95819]
synonym: "MEKKK 4 (human)" EXACT [UniProtKB:O95819]
synonym: "MEK kinase kinase 4 (human)" EXACT [UniProtKB:O95819]
synonym: "Nck-interacting kinase (human)" EXACT [UniProtKB:O95819]
synonym: "HPK/GCK-like kinase HGK (human)" EXACT [UniProtKB:O95819]
synonym: "MAPK/ERK kinase kinase kinase 4 (human)" EXACT [UniProtKB:O95819]
xref: DTO:03100296
xref: UniProtKB:O95819
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003043 ! mitogen-activated protein kinase kinase kinase kinase 4
relationship: has_gene_template HGNC:6866 ! MAP4K4 (human)

[Term]
id: PR:O95819-3
name: mitogen-activated protein kinase kinase kinase kinase 4 isoform h3 (human)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-3." [PRO:DNx, UniProtKB:O95819]
comment: Category=organism-sequence.
synonym: "hMAP4K4/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O95819-3
is_a: PR:O95819 ! mitogen-activated protein kinase kinase kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95819-2
name: mitogen-activated protein kinase kinase kinase kinase 4 isoform h2 (human)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-2." [PRO:DNx, UniProtKB:O95819]
comment: Category=organism-sequence.
synonym: "hMAP4K4/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O95819-2
is_a: PR:O95819 ! mitogen-activated protein kinase kinase kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O95819-1
name: mitogen-activated protein kinase kinase kinase kinase 4 isoform h1 (human)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95819-1." [PRO:DNx, UniProtKB:O95819]
comment: Category=organism-sequence.
synonym: "hMAP4K4/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "mitogen-activated protein kinase kinase kinase kinase 4 isoform Tumor-associated (human)" EXACT [UniProtKB:O95819]
xref: UniProtKB:O95819-1
is_a: PR:O95819 ! mitogen-activated protein kinase kinase kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q23356-1
name: serine/threonine-protein kinase mig-15 isoform c (worm)
def: "A serine/threonine-protein kinase mig-15 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q23356-1." [PRO:DNx, UniProtKB:Q23356]
comment: Category=organism-sequence.
synonym: "MAP4K4/iso:c (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q23356-1
is_a: PR:Q23356 ! serine/threonine-protein kinase mig-15 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:000048312
name: mitogen-activated protein kinase kinase kinase kinase 4, initiator methionine removed form (human)
def: "A mitogen-activated protein kinase kinase kinase kinase 4 (human) that has had the initiator methionine removed. UniProtKB:O95819, 2-1239." [PRO:DNx, Reactome:R-HSA-3214893]
comment: Category=organism-modification.
synonym: "PRO_0000086280" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMAP4K4/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O95819, 2-1239" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3214893 "PR:000048312 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:O95819 ! mitogen-activated protein kinase kinase kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens