[Term]
id: PR:000049991
name: leucine-rich repeat serine/threonine-protein kinase 2 sequence variant R1628P (human)
def: "A leucine-rich repeat serine/threonine-protein kinase 2 (human) that has a Pro residue at the position equivalent to Arg-1628 of the amino acid sequence represented by UniProtKB:Q5S007. UniProtKB:Q5S007, Arg-1628, CHEBI:50342." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hLRRK2/var:R1628P" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q5S007, Arg-1628, CHEBI:50342" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_024951
is_a: PR:Q5S007 ! leucine-rich repeat serine/threonine-protein kinase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q5S006
name: leucine-rich repeat serine/threonine-protein kinase 2 (mouse)
def: "A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of mouse." [OMA:Q5S006, PRO:DNx]
comment: Category=organism-gene.
synonym: "Lrrk2" RELATED Gene-based [UniProtKB:Q5S006]
synonym: "mLRRK2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5S006
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003033 ! leucine-rich repeat serine/threonine-protein kinase 2
relationship: has_gene_template MGI:1913975 ! Lrrk2 (mouse)

[Term]
id: PR:000003033
name: leucine-rich repeat serine/threonine-protein kinase 2
def: "A protein that is a translation product of the human LRRK2 gene or a 1:1 ortholog thereof. LRRK2 belongs to a gene family known as Roco. Roco genes encode for large proteins that have a characteristic GTPase domain, named Roc, plus a domain of unknown function called COR. Several Roco proteins also contain a protein kinase domain. Leucine-rich repeat serine/threonine-protein kinase 2 contains an N-terminal repeat that is unique to this protein." [PMID:16966681, PRO:CNA]
comment: Category=gene.
synonym: "LRRK2" EXACT PRO-short-label [PRO:DNx]
synonym: "PARK8" RELATED Gene-based []
synonym: "dardarin" EXACT []
xref: IUPHARobj:2059
is_a: PR:000000001 ! protein

[Term]
id: PR:Q5S007
name: leucine-rich repeat serine/threonine-protein kinase 2 (human)
def: "A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q5S007]
comment: Category=organism-gene.
synonym: "LRRK2" RELATED Gene-based [UniProtKB:Q5S007]
synonym: "PARK8" RELATED Gene-based [UniProtKB:Q5S007]
synonym: "hLRRK2" EXACT PRO-short-label [PRO:DNx]
synonym: "dardarin (human)" EXACT [UniProtKB:Q5S007]
xref: Reactome:R-HSA-5661173 "PR:Q5S007 located_in GO:0005829"
xref: DTO:03100273
xref: UniProtKB:Q5S007
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003033 ! leucine-rich repeat serine/threonine-protein kinase 2
relationship: has_gene_template HGNC:18618 ! LRRK2 (human)