[Term]
id: PR:P55212
name: caspase-6 (human)
def: "A caspase-6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P55212]
comment: Category=organism-gene.
synonym: "MCH2" RELATED Gene-based [UniProtKB:P55212]
synonym: "CASP6" RELATED Gene-based [UniProtKB:P55212]
synonym: "hCASP6" EXACT PRO-short-label [PRO:DNx]
synonym: "CSP-6 (human)" EXACT [UniProtKB:P55212]
synonym: "CASP-6 (human)" EXACT [UniProtKB:P55212]
synonym: "apoptotic protease Mch-2 (human)" EXACT [UniProtKB:P55212]
xref: Reactome:R-HSA-6798132 "PR:P55212 located_in GO:0005829"
xref: UniProtKB:P55212
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002315 ! caspase-6
relationship: has_gene_template HGNC:1507 ! CASP6 (human)

[Term]
id: PR:O35397
name: caspase-6 (rat)
def: "A caspase-6 that is encoded in the genome of rat." [PANTHER:PTHR10454:SF29, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mch2" RELATED Gene-based [UniProtKB:O35397]
synonym: "Casp6" RELATED Gene-based [UniProtKB:O35397]
synonym: "rCASP6" EXACT PRO-short-label [PRO:DNx]
synonym: "CASP-6 (rat)" EXACT [UniProtKB:O35397]
synonym: "apoptotic protease Mch-2 (rat)" EXACT [UniProtKB:O35397]
xref: UniProtKB:O35397
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002315 ! caspase-6
relationship: has_gene_template RGD:70967 ! Casp6 (rat)

[Term]
id: PR:000002457
name: caspase-6 subunit p18
def: "A caspase-6 isoform 1 that corresponds to the N-terminal portion after removal of the propeptides. Example: UniProtKB:P55212-1, 24-179." [PMID:8900201, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "CASP6/p18" EXACT PRO-short-label [PRO:DNx]
synonym: "Mch2alpha p18" EXACT []
synonym: "caspase-6 large subunit" EXACT []
is_a: PR:000002406 ! caspase-6 isoform 1
relationship: output_of GO:0016485 ! protein processing
relationship: lacks_part SO:0001062 ! propeptide

[Term]
id: PR:000002456
name: caspase-6 subunit p11
def: "A caspase-6 isoform 1 that corresponds to the C-terminal portion after removal of the propeptides. UniProtKB:P55212-1, 194-293." [PMID:8900201, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "CASP6/p11" EXACT PRO-short-label [PRO:DNx]
synonym: "Mch2alpha p11" EXACT []
synonym: "caspase-6 small subunit" EXACT []
is_a: PR:000002406 ! caspase-6 isoform 1
relationship: output_of GO:0016485 ! protein processing
relationship: lacks_part SO:0001062 ! propeptide

[Term]
id: PR:000002315
name: caspase-6
def: "A caspase-3-like protease that is a translation product of the human CASP6 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "MCH2" RELATED Gene-based []
synonym: "CASP6" EXACT PRO-short-label [PRO:DNx]
synonym: "CASP-6" EXACT []
synonym: "apoptotic protease Mch-2" EXACT []
xref: IUPHARobj:1622
xref: PANTHER:PTHR10454:SF29
is_a: PR:000002196 ! caspase-3-like protease

[Term]
id: PR:A0A1D5PPP7
name: caspase-6 (chicken)
def: "A caspase-6 that is encoded in the genome of chicken." [OMA:A0A1D5PPP7, PRO:DNx]
comment: Category=organism-gene.
synonym: "CASP6" RELATED Gene-based [UniProtKB:A0A1D5PPP7]
synonym: "chick-CASP6" EXACT PRO-short-label [PRO:DNx]
synonym: "CASP-6 (chicken)" EXACT [UniProtKB:A0A1D5PPP7]
xref: UniProtKB:A0A1D5PPP7
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000002315 ! caspase-6
relationship: has_gene_template NCBIGene:395477 ! CASP6 (chicken)

[Term]
id: PR:O08738-1
name: caspase-6 isoform 1 (mouse)
def: "A caspase-6 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mCASP6/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O08738-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002407 ! caspase-6 isoform 2

[Term]
id: PR:O08738
name: caspase-6 (mouse)
def: "A caspase-6 that is encoded in the genome of mouse." [OMA:O08738, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mch2" RELATED Gene-based [UniProtKB:O08738]
synonym: "Casp6" RELATED Gene-based [UniProtKB:O08738]
synonym: "mCASP6" EXACT PRO-short-label [PRO:DNx]
synonym: "CASP-6 (mouse)" EXACT [UniProtKB:O08738]
synonym: "apoptotic protease Mch-2 (mouse)" EXACT [UniProtKB:O08738]
xref: UniProtKB:O08738
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002315 ! caspase-6
relationship: has_gene_template MGI:1312921 ! Casp6 (mouse)

[Term]
id: PR:000002406
name: caspase-6 isoform 1
def: "A caspase-6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55212-1 or a 1:1 ortholog thereof." [PMID:7796396]
comment: Category=sequence.
synonym: "CASP6/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-6 isoform alpha" EXACT []
is_a: PR:000002315 ! caspase-6

[Term]
id: PR:000002407
name: caspase-6 isoform 2
def: "A caspase-6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O08738-1 or a 1:1 ortholog thereof." [PRO:DAN, PRO:JAN]
comment: Category=sequence.
synonym: "CASP6/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002315 ! caspase-6

[Term]
id: PR:000050093
name: caspase-6 subunit p18 (human)
def: "A caspase-6 subunit p18 in human. Example: UniProtKB:P55212-1, 24-179." [PRO:DNx, UniProtKB:P55212]
comment: Category=organism-modification.
synonym: "hCASP6/p18" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000004609" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P55212-1, 24-179" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002457 ! caspase-6 subunit p18

[Term]
id: PR:P55212-1
name: caspase-6 isoform Alpha (human)
def: "A caspase-6 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55212]
comment: Category=organism-sequence.
synonym: "hCASP6/iso:Alpha" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P55212-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002406 ! caspase-6 isoform 1

[Term]
id: PR:000018765
name: caspase-6 proteolytic cleavage product
def: "A caspase-6 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "CASP6/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000002315 ! caspase-6

[Term]
id: PR:000002408
name: caspase-6 isoform 3
def: "A caspase-6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55212-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "CASP6/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-6 isoform beta" EXACT []
is_a: PR:000002315 ! caspase-6

[Term]
id: PR:P55212-2
name: caspase-6 isoform Beta (human)
def: "A caspase-6 isoform 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCASP6/iso:Beta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P55212-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002408 ! caspase-6 isoform 3

[Term]
id: PR:000050094
name: caspase-6 subunit p11 (human)
def: "A caspase-6 subunit p11 in human. Example: UniProtKB:P55212-1, 194-293." [PRO:DNx, UniProtKB:P55212]
comment: Category=organism-modification.
synonym: "hCASP6/p11" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000004611" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P55212-1, 194-293" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002456 ! caspase-6 subunit p11

[Term]
id: PR:000045840
name: caspase-6 phosphorylated 1 (human)
def: "A caspase-6 (human) that has been phosphorylated at the position equivalent to Ser-257 of the amino acid sequence represented by UniProtKB:P55212-1. Example: UniProtKB:P55212-1, Ser-257, MOD:00046." [PMID:15273717, iPTMnet:P55212]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15273717). Status=unreviewed.
synonym: "hCASP6/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P55212-1, Ser-257, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P55212 ! caspase-6 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens