[Term]
id: PR:000002312
name: caspase-3
def: "A caspase-3-like protease that is a translation product of the human CASP3 gene or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=gene.
synonym: "LICE" EXACT []
synonym: "CASP3" EXACT PRO-short-label [PRO:DNx]
synonym: "CPP32" RELATED Gene-based []
synonym: "SCA-1" RELATED []
synonym: "CASP-3" EXACT []
synonym: "CPP-32" EXACT []
synonym: "apopain" EXACT []
synonym: "protein Yama" EXACT []
synonym: "cysteine protease CPP32" EXACT []
synonym: "SREBP cleavage activity 1" EXACT []
xref: IUPHARobj:1619
xref: PANTHER:PTHR10454:SF30
is_a: PR:000002196 ! caspase-3-like protease

[Term]
id: PR:P55213
name: caspase-3 (rat)
def: "A caspase-3 that is encoded in the genome of rat." [OMA:P55213, PANTHER:PTHR10454:SF30, PRO:DNx]
comment: Category=organism-gene.
synonym: "Casp3" RELATED Gene-based [UniProtKB:P55213]
synonym: "Cpp32" RELATED Gene-based [UniProtKB:P55213]
synonym: "rCASP3" EXACT PRO-short-label [PRO:DNx]
synonym: "IRP (rat)" EXACT [UniProtKB:P55213]
synonym: "LICE (rat)" EXACT [UniProtKB:P55213]
synonym: "SCA-1 (rat)" EXACT [UniProtKB:P55213]
synonym: "CASP-3 (rat)" EXACT [UniProtKB:P55213]
synonym: "CPP-32 (rat)" EXACT [UniProtKB:P55213]
synonym: "apopain (rat)" EXACT [UniProtKB:P55213]
synonym: "protein Yama (rat)" EXACT [UniProtKB:P55213]
synonym: "cysteine protease CPP32 (rat)" EXACT [UniProtKB:P55213]
synonym: "SREBP cleavage activity 1 (rat)" EXACT [UniProtKB:P55213]
xref: UniProtKB:P55213
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002312 ! caspase-3
relationship: has_gene_template RGD:2275 ! Casp3 (rat)

[Term]
id: PR:000002455
name: caspase-3 isoform 1 cleaved 2
def: "A caspase-3 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-3 subunit p17." [PRO:CNA]
comment: Category=modification.
synonym: "CASP3/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-3 subunit p17" EXACT []
is_a: PR:000002402 ! caspase-3 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000002454
name: caspase-3 isoform 1 cleaved 1
def: "A caspase-3 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-3 subunit p12." [PRO:CNA]
comment: Category=modification.
synonym: "CASP3/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-3 subunit p12" EXACT []
is_a: PR:000002402 ! caspase-3 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:P70677
name: caspase-3 (mouse)
def: "A caspase-3 that is encoded in the genome of mouse." [OMA:P70677, PRO:DNx]
comment: Category=organism-gene.
synonym: "Casp3" RELATED Gene-based [UniProtKB:P70677]
synonym: "Cpp32" RELATED Gene-based [UniProtKB:P70677]
synonym: "mCASP3" EXACT PRO-short-label [PRO:DNx]
synonym: "LICE (mouse)" EXACT [UniProtKB:P70677]
synonym: "SCA-1 (mouse)" RELATED [UniProtKB:P70677]
synonym: "CASP-3 (mouse)" EXACT [UniProtKB:P70677]
synonym: "CPP-32 (mouse)" EXACT [UniProtKB:P70677]
synonym: "apopain (mouse)" EXACT [UniProtKB:P70677]
synonym: "protein Yama (mouse)" EXACT [UniProtKB:P70677]
synonym: "cysteine protease CPP32 (mouse)" EXACT [UniProtKB:P70677]
synonym: "SREBP cleavage activity 1 (mouse)" EXACT [UniProtKB:P70677]
xref: UniProtKB:P70677
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002312 ! caspase-3
relationship: has_gene_template MGI:107739 ! Casp3 (mouse)

[Term]
id: PR:P42574-1
name: caspase-3 isoform 1 (human)
def: "A caspase-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCASP3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42574-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002402 ! caspase-3 isoform 1

[Term]
id: PR:P42574
name: caspase-3 (human)
def: "A caspase-3 that is encoded in the genome of human." [PRO:JAN, UniProtKB:P42574]
comment: Category=organism-gene.
synonym: "CASP3" RELATED Gene-based [UniProtKB:P42574]
synonym: "CPP32" RELATED Gene-based [UniProtKB:P42574]
synonym: "hCASP3" EXACT PRO-short-label [PRO:DNx]
synonym: "SCA-1 (human)" EXACT [UniProtKB:P42574]
synonym: "CASP-3 (human)" EXACT [UniProtKB:P42574]
synonym: "CPP-32 (human)" EXACT [UniProtKB:P42574]
synonym: "apopain (human)" EXACT [UniProtKB:P42574]
synonym: "protein Yama (human)" EXACT [UniProtKB:P42574]
synonym: "cysteine protease CPP32 (human)" EXACT [UniProtKB:P42574]
synonym: "SREBP cleavage activity 1 (human)" EXACT [UniProtKB:P42574]
xref: Reactome:R-HSA-57021 "PR:P42574 located_in GO:0005829"
xref: UniProtKB:P42574
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002312 ! caspase-3
relationship: has_gene_template HGNC:1504 ! CASP3 (human)

[Term]
id: PR:000002402
name: caspase-3 isoform 1
def: "A caspase-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70677-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "CASP3/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002312 ! caspase-3

[Term]
id: PR:000026877
name: caspase-3 isoform 1 cleaved 2 (human)
def: "A caspase-3 isoform 1 cleaved 2 in human. UniProtKB:P42574-1, 29-175." [PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000004571" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hCASP3/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42574-1, 29-175" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "human caspase-3 subunit p17" EXACT []
synonym: "caspase-3 large subunit (human)" EXACT []
xref: Reactome:R-HSA-202916 "PR:000026877 located_in GO:0005886"
xref: Reactome:R-HSA-211194 "PR:000026877 located_in GO:0005654"
xref: Reactome:R-HSA-141644 "PR:000026877 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002455 ! caspase-3 isoform 1 cleaved 2

[Term]
id: PR:000026876
name: caspase-3 isoform 1 cleaved 1 (human)
def: "A caspase-3 isoform 1 cleaved 1 in human. UniProtKB:P42574-1, 176-277." [PMID:11931755, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000004572" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hCASP3/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42574-1, 176-277" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "human caspase-3 subunit p12" EXACT []
synonym: "caspase-3 small subunit (human)" EXACT []
xref: Reactome:R-HSA-202914 "PR:000026876 located_in GO:0005886"
xref: Reactome:R-HSA-211203 "PR:000026876 located_in GO:0005654"
xref: Reactome:R-HSA-141646 "PR:000026876 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002454 ! caspase-3 isoform 1 cleaved 1

[Term]
id: PR:P70677-1
name: caspase-3 isoform 1 (mouse)
def: "A caspase-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCASP3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70677-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002402 ! caspase-3 isoform 1

[Term]
id: PR:000018762
name: caspase-3 proteolytic cleavage product
def: "A caspase-3 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "CASP3/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000002312 ! caspase-3