[Term]
id: PR:000002311
name: caspase-2
def: "A caspase-1-like protease that is a translation product of the human CASP2 gene or a 1:1 ortholog thereof. This protein is involved in the activation cascade of caspases responsible for apoptosis execution." [PRO:WCB]
comment: Category=gene.
synonym: "ICH1" RELATED Gene-based []
synonym: "CASP2" EXACT PRO-short-label [PRO:DNx]
synonym: "NEDD2" RELATED Gene-based []
synonym: "CASP-2" EXACT []
synonym: "NEDD-2" EXACT []
synonym: "protease ICH-1" EXACT []
synonym: "neural precursor cell expressed developmentally down-regulated protein 2" EXACT []
xref: IUPHARobj:1618
is_a: PR:000002195 ! caspase-1-like protease

[Term]
id: PR:000050112
name: caspase-2 subunit p12 (human)
def: "A caspase-2 subunit p12 in human. Example: UniProtKB:P42575-1, 348-452." [PRO:DNx, UniProtKB:P42575]
comment: Category=organism-modification.
synonym: "hCASP2/p12" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000004545" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P42575-1, 348-452" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002453 ! caspase-2 subunit p12

[Term]
id: PR:000050111
name: caspase-2 subunit p13 (human)
def: "A caspase-2 subunit p13 in human. Example: UniProtKB:P42575-1, 334-452." [PRO:DNx, UniProtKB:P42575]
comment: Category=organism-modification.
synonym: "hCASP2/p13" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000004544" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P42575-1, 334-452" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002452 ! caspase-2 subunit p13

[Term]
id: PR:000050110
name: caspase-2 subunit p18 (human)
def: "A caspase-2 subunit p18 in human. Example: UniProtKB:P42575-1, 170-325." [PRO:DNx, UniProtKB:P42575]
comment: Category=organism-modification.
synonym: "hCASP2/p18" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000004542" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P42575-1, 170-325" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002451 ! caspase-2 subunit p18

[Term]
id: PR:000046570
name: caspase-2, initiator methionine removed form (human)
def: "A caspase-2 (human) that has had the initiator methionine removed. UniProtKB:P42575, 2-452." [PRO:DNx, Reactome:R-HSA-622412]
comment: Category=organism-modification.
synonym: "hCASP2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42575, 2-452" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-622412 "PR:000046570 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P42575 ! caspase-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P42575
name: caspase-2 (human)
def: "A caspase-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P42575]
comment: Category=organism-gene.
synonym: "ICH1" RELATED Gene-based [UniProtKB:P42575]
synonym: "CASP2" RELATED Gene-based [UniProtKB:P42575]
synonym: "NEDD2" RELATED Gene-based [UniProtKB:P42575]
synonym: "hCASP2" EXACT PRO-short-label [PRO:DNx]
synonym: "CASP-2 (human)" EXACT [UniProtKB:P42575]
synonym: "NEDD-2 (human)" EXACT [UniProtKB:P42575]
synonym: "protease ICH-1 (human)" EXACT [UniProtKB:P42575]
synonym: "neural precursor cell expressed developmentally down-regulated protein 2 (human)" EXACT [UniProtKB:P42575]
xref: UniProtKB:P42575
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002311 ! caspase-2
relationship: has_gene_template HGNC:1503 ! CASP2 (human)

[Term]
id: PR:P42575-3
name: caspase-2 isoform h3 (human)
def: "A caspase-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42575-3." [PRO:DNx, UniProtKB:P42575]
comment: Category=organism-sequence.
synonym: "hCASP2/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-2 isoform Casp-2L-Pro (human)" EXACT [UniProtKB:P42575]
xref: UniProtKB:P42575-3
is_a: PR:P42575 ! caspase-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P42575-2
name: caspase-2 isoform 2 (human)
def: "A caspase-2 isoform 2 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP2/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-2 isoform ICH-1S (human)" EXACT [UniProtKB:P42575]
xref: UniProtKB:P42575-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002401 ! caspase-2 isoform 2

[Term]
id: PR:P42575-1
name: caspase-2 isoform 1 (human)
def: "A caspase-2 isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP2/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-2 isoform ICH-1L (human)" EXACT [UniProtKB:P42575]
xref: UniProtKB:P42575-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002400 ! caspase-2 isoform 1

[Term]
id: PR:000045782
name: caspase-2 phosphorylated 1 (human)
def: "A caspase-2 (human) that has been phosphorylated at the position equivalent to Ser-157 of the amino acid sequence represented by UniProtKB:P42575-1. Example: UniProtKB:P42575-1, Ser-157, MOD:00046." [PMID:16193064, iPTMnet:P42575]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16193064). Status=unreviewed.
synonym: "hCASP2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42575-1, Ser-157, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P42575 ! caspase-2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens