[Term]
id: PR:P43527
name: caspase-1 (rat)
def: "A caspase-1 that is encoded in the genome of rat." [PANTHER:PTHR10454:SF13, PRO:DNx]
comment: Category=organism-gene.
synonym: "Casp1" RELATED Gene-based [UniProtKB:P43527]
synonym: "Il1bc" RELATED Gene-based [UniProtKB:P43527]
synonym: "Il1bce" RELATED Gene-based [UniProtKB:P43527]
synonym: "rCASP1" EXACT PRO-short-label [PRO:DNx]
synonym: "ICE (rat)" EXACT [UniProtKB:P43527]
synonym: "p45 (rat)" BROAD [UniProtKB:P43527]
synonym: "CASP-1 (rat)" EXACT [UniProtKB:P43527]
synonym: "IL-1BC (rat)" EXACT [UniProtKB:P43527]
synonym: "IL-1 beta-converting enzyme (rat)" EXACT [UniProtKB:P43527]
synonym: "interleukin-1 beta convertase (rat)" EXACT [UniProtKB:P43527]
synonym: "interleukin-1 beta-converting enzyme (rat)" EXACT [UniProtKB:P43527]
xref: UniProtKB:P43527
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002309 ! caspase-1
relationship: has_gene_template RGD:2274 ! Casp1 (rat)

[Term]
id: PR:000002309
name: caspase-1
def: "A caspase-1-like protease that is a translation product of the human CASP1 gene or a 1:1 ortholog thereof. The active form of this protein proteolytically cleaves pro-IL-1beta to its mature, active form. The holoenzyme is a homodimer of catalytic domains, each of which contains the cleaved products caspase-1 p20 and p10 subunits." [PMID:8044845, PRO:WCB]
comment: Category=gene.
synonym: "ICE" EXACT []
synonym: "p45" BROAD [PRO:DNx]
synonym: "CASP1" EXACT PRO-short-label [PRO:DNx]
synonym: "IL1BC" RELATED Gene-based []
synonym: "CASP-1" EXACT []
synonym: "IL-1BC" EXACT []
synonym: "IL1BCE" RELATED Gene-based []
synonym: "IL-1 beta-converting enzyme" EXACT []
synonym: "interleukin-1 beta convertase" EXACT []
synonym: "interleukin-1 beta-converting enzyme" EXACT []
xref: IUPHARobj:1617
is_a: PR:000002195 ! caspase-1-like protease