[Term]
id: PR:P29466-5
name: caspase-1 isoform epsilon (human)
def: "A caspase-1 isoform 5 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP1/iso:epsilon" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29466-5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002394 ! caspase-1 isoform 5

[Term]
id: PR:P29466-4
name: caspase-1 isoform delta (human)
def: "A caspase-1 isoform 4 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP1/iso:delta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29466-4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002393 ! caspase-1 isoform 4

[Term]
id: PR:P29466-1
name: caspase-1 isoform alpha (human)
def: "A caspase-1 isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP1/iso:alpha" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29466-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002390 ! caspase-1 isoform 1

[Term]
id: PR:P29466-3
name: caspase-1 isoform gamma (human)
def: "A caspase-1 isoform 3 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP1/iso:gamma" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29466-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002392 ! caspase-1 isoform 3

[Term]
id: PR:P29466-2
name: caspase-1 isoform beta (human)
def: "A caspase-1 isoform 2 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP1/iso:beta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29466-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002391 ! caspase-1 isoform 2

[Term]
id: PR:000002309
name: caspase-1
def: "A caspase-1-like protease that is a translation product of the human CASP1 gene or a 1:1 ortholog thereof. The active form of this protein proteolytically cleaves pro-IL-1beta to its mature, active form. The holoenzyme is a homodimer of catalytic domains, each of which contains the cleaved products caspase-1 p20 and p10 subunits." [PMID:8044845, PRO:WCB]
comment: Category=gene.
synonym: "ICE" EXACT []
synonym: "p45" BROAD [PRO:DNx]
synonym: "CASP1" EXACT PRO-short-label [PRO:DNx]
synonym: "IL1BC" RELATED Gene-based []
synonym: "CASP-1" EXACT []
synonym: "IL-1BC" EXACT []
synonym: "IL1BCE" RELATED Gene-based []
synonym: "IL-1 beta-converting enzyme" EXACT []
synonym: "interleukin-1 beta convertase" EXACT []
synonym: "interleukin-1 beta-converting enzyme" EXACT []
xref: IUPHARobj:1617
is_a: PR:000002195 ! caspase-1-like protease

[Term]
id: PR:P29466
name: caspase-1 (human)
def: "A caspase-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P29466]
comment: Category=organism-gene.
synonym: "CASP1" RELATED Gene-based [UniProtKB:P29466]
synonym: "IL1BC" RELATED Gene-based [UniProtKB:P29466]
synonym: "IL1BCE" RELATED Gene-based [UniProtKB:P29466]
synonym: "hCASP1" EXACT PRO-short-label [PRO:DNx]
synonym: "ICE (human)" EXACT [UniProtKB:P29466]
synonym: "p45 (human)" BROAD [UniProtKB:P29466]
synonym: "CASP-1 (human)" EXACT [UniProtKB:P29466]
synonym: "IL-1BC (human)" EXACT [UniProtKB:P29466]
synonym: "IL-1 beta-converting enzyme (human)" EXACT [UniProtKB:P29466]
synonym: "interleukin-1 beta convertase (human)" EXACT [UniProtKB:P29466]
synonym: "interleukin-1 beta-converting enzyme (human)" EXACT [UniProtKB:P29466]
xref: Reactome:R-HSA-448692 "PR:P29466 located_in GO:0005829"
xref: UniProtKB:P29466
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002309 ! caspase-1
relationship: has_gene_template HGNC:1499 ! CASP1 (human)