[Term] id: PR:000003232 name: Bcl2-associated agonist of cell death isoform 2 phosphorylated 1 def: "A Bcl2-associated agonist of cell death isoform 2 phosphorylated form in which the phosphorylation occurs on the indicated Ser residues within each of two RxRxxSxP motifs in the BH3 domain. The latter site is the major PKA phosphorylation site. Phosphorylation on these residues favors binding to 14-3-3 proteins. Example: UniProtKB:Q92934-1, Ser-75/Ser-99, MOD:00046." [PRO:DAN, PRO:JAN] comment: Category=modification. synonym: "BAD/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003231 ! Bcl2-associated agonist of cell death isoform 2 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000003233 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue by the action of JNK1. Example: UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN] comment: Category=modification. synonym: "BAD/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003084 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated form relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000003231 name: Bcl2-associated agonist of cell death isoform 2 phosphorylated form def: "A Bcl2-associated agonist of cell death isoform 2 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "BAD/iso:2/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000002281 ! Bcl2-associated agonist of cell death isoform 2 [Term] id: PR:000044747 name: Bcl2-associated agonist of cell death isoform 1 unmodified form (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 unmodified form in mouse." [PRO:DNx] comment: Category=organism-modification. synonym: "mBAD/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002843 ! Bcl2-associated agonist of cell death isoform 1 unmodified form [Term] id: PR:000003238 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at one of the two Ser residues which are the major sites of phosphorylation by MAPK and AKT signaling. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN] comment: Category=modification. synonym: "BAD/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003084 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000002184 name: Bcl2-associated agonist of cell death def: "A protein that is a translation product of the human BAD gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "BAD" EXACT PRO-short-label [PRO:DNx] synonym: "BBC6" RELATED Gene-based [] synonym: "BCL2L8" RELATED Gene-based [] synonym: "Bcl2-L-8" EXACT [] synonym: "Bcl-2-like protein 8" EXACT [] synonym: "Bcl-2-binding component 6" EXACT [] synonym: "Bcl2 antagonist of cell death" EXACT [] synonym: "bcl-XL/Bcl-2-associated death promoter" EXACT [] xref: PIRSF:PIRSF023966 is_a: PR:000000001 ! protein [Term] id: PR:000003251 name: Bcl2-associated agonist of cell death isoform 3 def: "A Bcl2-associated agonist of cell death that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35147-2 or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=sequence. synonym: "BAD/iso:3" EXACT PRO-short-label [PRO:DNx] synonym: "BAD isoform beta" EXACT [] is_a: PR:000002184 ! Bcl2-associated agonist of cell death [Term] id: PR:000003269 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs by the action of cdc-2. Example: UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN] comment: Category=modification. synonym: "BAD/iso:1/Phos:6" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003084 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:Q92934 name: Bcl2-associated agonist of cell death (human) def: "A Bcl2-associated agonist of cell death that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q92934] comment: Category=organism-gene. synonym: "BAD" RELATED Gene-based [UniProtKB:Q92934] synonym: "BBC6" RELATED Gene-based [UniProtKB:Q92934] synonym: "hBAD" EXACT PRO-short-label [PRO:DNx] synonym: "BCL2L8" RELATED Gene-based [UniProtKB:Q92934] synonym: "Bcl2-L-8 (human)" EXACT [UniProtKB:Q92934] synonym: "Bcl-2-like protein 8 (human)" EXACT [UniProtKB:Q92934] synonym: "Bcl-2-binding component 6 (human)" EXACT [UniProtKB:Q92934] synonym: "Bcl2 antagonist of cell death (human)" EXACT [UniProtKB:Q92934] synonym: "Bcl-xL/Bcl-2-associated death promoter (human)" EXACT [UniProtKB:Q92934] xref: UniProtKB:Q92934 xref: Reactome:R-HSA-50662 "PR:Q92934 located_in GO:0005829" xref: Reactome:R-HSA-114242 "PR:Q92934 located_in GO:0005741" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002184 ! Bcl2-associated agonist of cell death relationship: has_gene_template HGNC:936 ! BAD (human) [Term] id: PR:O35147-2 name: Bcl2-associated agonist of cell death isoform Beta (rat) def: "A Bcl2-associated agonist of cell death isoform 3 that is encoded in the genome of rat." [PRO:JAN] comment: Category=organism-sequence. synonym: "rBAD/iso:Beta" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O35147-2 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000003251 ! Bcl2-associated agonist of cell death isoform 3 [Term] id: PR:O35147-1 name: Bcl2-associated agonist of cell death isoform Alpha (rat) def: "A Bcl2-associated agonist of cell death isoform 1 that is encoded in the genome of rat." [PRO:JAN] comment: Category=organism-sequence. synonym: "rBAD/iso:Alpha" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O35147-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000002280 ! Bcl2-associated agonist of cell death isoform 1 [Term] id: PR:000037809 name: Bcl2-associated agonist of cell death isoform 1 unphosphorylated 1 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 (mouse) that lacks phosphorylation on the indicated Ser residues located within each of two RxRxxSxP motifs, and the indicated Ser residue within the motif RRxS in the BH3 domain, which is the major PKA phosphorylation site. Example: UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, PR:000026291." [PMID:16403219, PRO:DAN, PRO:KER] comment: Category=organism-modification. synonym: "mBAD/iso:1/UnPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q61337-1 ! Bcl2-associated agonist of cell death isoform 1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000025849 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at two Ser residues by activation of RSK. Phosphorylation on these residues favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046." [PMID:10880354, PRO:CNA] comment: Category=modification. synonym: "BAD/iso:1/Phos:7" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003084 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000026133 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:JAN] comment: Category=organism-modification. Kinase=("AKT"; PR:000029189). Kinase=("PKA"; PR:000029188). Kinase=("RPS6KA3"; PR:000014284). synonym: "mBAD/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003086 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000026134 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 (rat) def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 in rat. UniProtKB:O35147-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PRO:JAN] comment: Category=organism-modification. synonym: "rBAD/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O35147-1, Ser-112, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000003087 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000026135 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 in mouse. UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN] comment: Category=organism-modification. Kinase=("MAPK8"; PR:000002206; Thr-201). synonym: "mBAD/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q61337-1, Thr-201, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003233 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000026136 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 in mouse. UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN] comment: Category=organism-modification. synonym: "mBAD/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q61337-1, Ser-136, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003238 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000026137 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 in mouse. UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN] comment: Category=organism-modification. Kinase=("cyclin B:Cdk1 complex"; PR:000029190; Ser-128). synonym: "mBAD/iso:1/Phos:6" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003269 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000026138 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046." [PMID:10880354, PRO:CNA] comment: Category=organism-modification. Kinase=("RPS6KA3"; PR:000014284; Ser-112). synonym: "mBAD/iso:1/Phos:7" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q61337-1, Ser-112/Ser-155, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000025849 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000026139 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 in mouse. UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA] comment: Category=organism-modification. Kinase=("PKA"; PR:000029188; Ser-155). synonym: "mBAD/iso:1/Phos:8" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q61337-1, Ser-155, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000025850 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000046455 name: Bcl2-associated agonist of cell death phosphorylated 2 (human) def: "A Bcl2-associated agonist of cell death (human) that has been post-translationally modified to include phosphoserine at position 91 of the amino acid sequence represented by UniProtKB:Q92934. UniProtKB:Q92934, Ser-91, MOD:00046." [PRO:DAN, Reactome:R-HSA-217297] comment: Category=organism-modification. Note: The modified site indicated here (Ser-91) is referred to as Ser-128 in some manuscripts. [PRO:DAN, PMID:12049737, PMID:15470142, PMID:14673001] synonym: "hBAD/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q92934, Ser-91, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-217297 "PR:000046455 located_in GO:0005829" is_a: PR:Q92934 ! Bcl2-associated agonist of cell death (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046456 name: Bcl2-associated agonist of cell death phosphorylated 3 (human) def: "A Bcl2-associated agonist of cell death (human) that has been post-translationally modified to include phosphoserine at position 99 of the amino acid sequence represented by UniProtKB:Q92934. UniProtKB:Q92934, Ser-99, MOD:00046." [PRO:DNx, Reactome:R-HSA-198335] comment: Category=organism-modification. synonym: "hBAD/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q92934, Ser-99, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-198335 "PR:000046456 located_in GO:0005829" is_a: PR:Q92934 ! Bcl2-associated agonist of cell death (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000003085 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at two Ser residues which are the major sites of phosphorylation by PKA and AKT signaling. The sites are the indicated serines within the RxRxxSxP motifs. Phosphorylation on these residues favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:CNA, PRO:DAN, PRO:JAN] comment: Category=modification. synonym: "p112p136BAD" EXACT [] synonym: "BAD/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003084 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000003084 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated form def: "A Bcl2-associated agonist of cell death isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "BAD/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000002280 ! Bcl2-associated agonist of cell death isoform 1 [Term] id: PR:000003087 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs upon activation of the MAPK pathway. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PMID:10880354, PRO:JAN] comment: Category=modification. synonym: "BAD/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003084 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000003086 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at the indicated Ser residues within each of two RxRxxSxP motifs, and within the RRxS motif located in the BH3 domain. Example: UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:CNA, PRO:DAN, PRO:JAN] comment: Category=modification. Note: The RRxS motif site is the major PKA phosphorylation site. Phosphorylation on these residues favors binding to 14-3-3 proteins. synonym: "inactive BAD" EXACT [] synonym: "BAD/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003084 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000002843 name: Bcl2-associated agonist of cell death isoform 1 unmodified form def: "A Bcl2-associated agonist of cell death isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx] comment: Category=modification. synonym: "BAD/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000002280 ! Bcl2-associated agonist of cell death isoform 1 intersection_of: has_part PR:000021935 ! immature protein part intersection_of: lacks_part PR:000025513 ! modified amino-acid residue disjoint_from: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000044749 name: Bcl2-associated agonist of cell death isoform 2 unmodified form (human) def: "A Bcl2-associated agonist of cell death isoform 2 unmodified form in human." [PRO:DNx] comment: Category=organism-modification. synonym: "hBAD/iso:2/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002844 ! Bcl2-associated agonist of cell death isoform 2 unmodified form [Term] id: PR:000044748 name: Bcl2-associated agonist of cell death isoform 1 unmodified form (rat) def: "A Bcl2-associated agonist of cell death isoform 1 unmodified form in rat." [PRO:DNx] comment: Category=organism-modification. synonym: "rBAD/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000002843 ! Bcl2-associated agonist of cell death isoform 1 unmodified form [Term] id: PR:000002844 name: Bcl2-associated agonist of cell death isoform 2 unmodified form def: "A Bcl2-associated agonist of cell death isoform 2 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx] comment: Category=modification. synonym: "BAD/iso:2/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000002281 ! Bcl2-associated agonist of cell death isoform 2 intersection_of: has_part PR:000021935 ! immature protein part intersection_of: lacks_part PR:000025513 ! modified amino-acid residue disjoint_from: PR:000018264 ! proteolytic cleavage product [Term] id: PR:Q92934-1 name: Bcl2-associated agonist of cell death isoform 1 (human) def: "A Bcl2-associated agonist of cell death isoform 2 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hBAD/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q92934-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002281 ! Bcl2-associated agonist of cell death isoform 2 [Term] id: PR:Q3U9H3 name: Bcl2-associated agonist of cell death isoform 2 (mouse) def: "A Bcl2-associated agonist of cell death isoform 2 that is encoded in the genome of mouse." [PRO:JAN] comment: Category=organism-sequence. synonym: "mCG_14907" RELATED Gene-based [UniProtKB:Q3U9H3] synonym: "mBAD/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "Bcl2-associated agonist of cell death, isoform CRA_a (mouse)" EXACT [UniProtKB:Q3U9H3] xref: UniProtKB:Q3U9H3 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002281 ! Bcl2-associated agonist of cell death isoform 2 [Term] id: PR:000025850 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated form in which the phosphorylation occurs at a Ser residue at the PKA/RSK consensus sequence RRxS. Phosphorylation on this residue favors binding to 14-3-3 proteins. Example: UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA] comment: Category=modification. synonym: "BAD/iso:1/Phos:8" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003084 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:Q61337-1 name: Bcl2-associated agonist of cell death isoform 1 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 that is encoded in the genome of mouse." [PRO:JAN] comment: Category=organism-sequence. synonym: "mBAD/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q61337-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002280 ! Bcl2-associated agonist of cell death isoform 1 [Term] id: PR:Q61337 name: Bcl2-associated agonist of cell death (mouse) def: "A Bcl2-associated agonist of cell death that is encoded in the genome of mouse." [OMA:Q61337, PRO:DNx] comment: Category=organism-gene. synonym: "Bad" RELATED Gene-based [UniProtKB:Q61337] synonym: "Bbc6" RELATED Gene-based [UniProtKB:Q61337] synonym: "mBAD" EXACT PRO-short-label [PRO:DNx] synonym: "BAD (mouse)" EXACT [UniProtKB:Q61337] synonym: "Bcl-2-binding component 6 (mouse)" EXACT [UniProtKB:Q61337] synonym: "Bcl2 antagonist of cell death (mouse)" EXACT [UniProtKB:Q61337] synonym: "Bcl-xL/Bcl-2-associated death promoter (mouse)" EXACT [UniProtKB:Q61337] xref: UniProtKB:Q61337 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002184 ! Bcl2-associated agonist of cell death relationship: has_gene_template MGI:1096330 ! Bad (mouse) [Term] id: PR:000026140 name: Bcl2-associated agonist of cell death isoform 2 phosphorylated 1 (human) def: "A Bcl2-associated agonist of cell death isoform 2 phosphorylated 1 in human. UniProtKB:Q92934-1, Ser-75/Ser-99, MOD:00046." [PMID:10195903, PMID:16932738, PRO:JAN] comment: Category=organism-modification. synonym: "hBAD/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q92934-1, Ser-75/Ser-99, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003232 ! Bcl2-associated agonist of cell death isoform 2 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000026167 name: Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 (mouse) def: "A Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:JAN] comment: Category=organism-modification. Kinase=("AKT"; PR:000029189). Kinase=("PKA"; PR:000029188). synonym: "mBAD/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003085 ! Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:O35147 name: Bcl2-associated agonist of cell death (rat) def: "A Bcl2-associated agonist of cell death that is encoded in the genome of rat." [OMA:O35147, PRO:DNx] comment: Category=organism-gene. synonym: "Bad" RELATED Gene-based [UniProtKB:O35147] synonym: "rBAD" EXACT PRO-short-label [PRO:DNx] synonym: "BAD (rat)" EXACT [UniProtKB:O35147] synonym: "Bcl-2-binding component 6 (rat)" EXACT [UniProtKB:O35147] synonym: "Bcl2 antagonist of cell death (rat)" EXACT [UniProtKB:O35147] synonym: "Bcl-xL/Bcl-2-associated death promoter (rat)" EXACT [UniProtKB:O35147] xref: UniProtKB:O35147 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000002184 ! Bcl2-associated agonist of cell death relationship: has_gene_template RGD:620103 ! Bad (rat) [Term] id: PR:000002280 name: Bcl2-associated agonist of cell death isoform 1 def: "A Bcl2-associated agonist of cell death that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61337-1 or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=sequence. synonym: "BAD/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "BAD isoform alpha" EXACT [] synonym: "bcl-xL/Bcl-2-associated death promoter" EXACT [] is_a: PR:000002184 ! Bcl2-associated agonist of cell death [Term] id: PR:000002281 name: Bcl2-associated agonist of cell death isoform 2 def: "A Bcl2-associated agonist of cell death that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92934-1 or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=sequence. synonym: "BAD/iso:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002184 ! Bcl2-associated agonist of cell death