[Term]
id: PR:000048075
name: tyrosine-protein kinase ITK/TSK phosphorylated 2 (human)
def: "A tyrosine-protein kinase ITK/TSK (human) that has been post-translationally modified to include phosphotyrosine at position 512 of the amino acid sequence represented by UniProtKB:Q08881. UniProtKB:Q08881, Tyr-512, MOD:00048." [PMID:9312162, PRO:DNx, Reactome:R-HSA-422519]
comment: Category=organism-modification. Requested by=ImmPort.
synonym: "hITK/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "hITK (pTyr511)" EXACT [PRO:ADD, GOC:add]
synonym: "UniProtKB:Q08881, Tyr-512, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-422519 "PR:000048075 located_in GO:0005829"
is_a: PR:Q08881 ! tyrosine-protein kinase ITK/TSK (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048074
name: tyrosine-protein kinase ITK/TSK phosphorylated 1 (human)
def: "A tyrosine-protein kinase ITK/TSK (human) that has been post-translationally modified to include phosphotyrosine at positions 180 and 512 of the amino acid sequence represented by UniProtKB:Q08881. UniProtKB:Q08881, Tyr-180/Tyr-512, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685616]
comment: Category=organism-modification.
synonym: "hITK/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q08881, Tyr-180/Tyr-512, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2685616 "PR:000048074 located_in GO:0005829"
is_a: PR:Q08881 ! tyrosine-protein kinase ITK/TSK (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q5STT8
name: tyrosine-protein kinase ITK/TSK isoform 2 (mouse)
def: "A tyrosine-protein kinase ITK/TSK isoform 2 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mITK/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "non-specific protein-tyrosine kinase isoform 2 (mouse)" EXACT [PRO:DNx]
xref: UniProtKB:Q5STT8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002239 ! tyrosine-protein kinase ITK/TSK isoform 2

[Term]
id: PR:Q08881-1
name: tyrosine-protein kinase ITK/TSK isoform 1 (human)
def: "A tyrosine-protein kinase ITK/TSK isoform 2 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hITK/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q08881-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002239 ! tyrosine-protein kinase ITK/TSK isoform 2

[Term]
id: PR:P08630-2
name: tyrosine-protein kinase Btk29A isoform A (fruit fly)
def: "A tyrosine-protein kinase Btk29A (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08630-2." [PRO:DNx, UniProtKB:P08630]
comment: Category=organism-sequence.
synonym: "fly-ITK/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase Btk29A isoform C (fruit fly)" EXACT [UniProtKB:P08630]
synonym: "tyrosine-protein kinase Btk29A isoform F (fruit fly)" EXACT [UniProtKB:P08630]
synonym: "tyrosine-protein kinase Btk29A isoform Type 1 (fruit fly)" EXACT [UniProtKB:P08630]
xref: UniProtKB:P08630-2
is_a: PR:P08630 ! tyrosine-protein kinase Btk29A (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P08630-1
name: tyrosine-protein kinase Btk29A isoform B (fruit fly)
def: "A tyrosine-protein kinase Btk29A (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08630-1." [PRO:DNx, UniProtKB:P08630]
comment: Category=organism-sequence.
synonym: "fly-ITK/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase Btk29A isoform D (fruit fly)" EXACT [UniProtKB:P08630]
synonym: "tyrosine-protein kinase Btk29A isoform E (fruit fly)" EXACT [UniProtKB:P08630]
synonym: "tyrosine-protein kinase Btk29A isoform Type 2 (fruit fly)" EXACT [UniProtKB:P08630]
xref: UniProtKB:P08630-1
is_a: PR:P08630 ! tyrosine-protein kinase Btk29A (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q19726
name: non-specific protein-tyrosine kinase (worm)
def: "A tyrosine-protein kinase ITK/TSK that is encoded in the genome of worm." [PRO:WCB]
comment: Category=organism-gene.
synonym: "ITK (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "CELE_F22D6.1" RELATED Gene-based [UniProtKB:Q19726]
xref: UniProtKB:Q19726
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000002111 ! tyrosine-protein kinase ITK/TSK
relationship: has_gene_template WormBase:WBGene00002198 ! kin-14 (worm)

[Term]
id: PR:000002111
name: tyrosine-protein kinase ITK/TSK
def: "A TEC-type tyrosine-protein kinase that is a translation product of the human ITK gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "EMT" RELATED Gene-based []
synonym: "ITK" EXACT PRO-short-label [PRO:DNx]
synonym: "LYK" RELATED Gene-based []
synonym: "Tlk" RELATED Gene-based []
synonym: "Tsk" RELATED Gene-based []
synonym: "kinase EMT" EXACT []
synonym: "kinase TLK" EXACT []
synonym: "T-cell-specific kinase" EXACT []
synonym: "tyrosine-protein kinase Lyk" EXACT []
synonym: "IL-2-inducible T-cell kinase" EXACT []
xref: IUPHARobj:2046
xref: PIRSF:PIRSF500766
is_a: PR:000001967 ! TEC-type tyrosine-protein kinase

[Term]
id: PR:Q03526-1
name: tyrosine-protein kinase ITK/TSK isoform 1 (mouse)
def: "A tyrosine-protein kinase ITK/TSK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mITK/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q03526-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002238 ! tyrosine-protein kinase ITK/TSK isoform 1

[Term]
id: PR:Q08881
name: tyrosine-protein kinase ITK/TSK (human)
def: "A tyrosine-protein kinase ITK/TSK that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q08881]
comment: Category=organism-gene.
synonym: "EMT" RELATED Gene-based [UniProtKB:Q08881]
synonym: "ITK" RELATED Gene-based [UniProtKB:Q08881]
synonym: "LYK" RELATED Gene-based [UniProtKB:Q08881]
synonym: "hITK" EXACT PRO-short-label [PRO:DNx]
synonym: "kinase EMT (human)" EXACT [UniProtKB:Q08881]
synonym: "T-cell-specific kinase (human)" EXACT [UniProtKB:Q08881]
synonym: "tyrosine-protein kinase Lyk (human)" EXACT [UniProtKB:Q08881]
synonym: "IL-2-inducible T-cell kinase (human)" EXACT [UniProtKB:Q08881]
synonym: "interleukin-2-inducible T-cell kinase (human)" EXACT [UniProtKB:Q08881]
xref: Reactome:R-HSA-202319 "PR:Q08881 located_in GO:0005829"
xref: DTO:03100194
xref: UniProtKB:Q08881
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002111 ! tyrosine-protein kinase ITK/TSK
relationship: has_gene_template HGNC:6171 ! ITK (human)

[Term]
id: PR:Q03526
name: tyrosine-protein kinase ITK/TSK (mouse)
def: "A tyrosine-protein kinase ITK/TSK that is encoded in the genome of mouse." [OMA:Q03526, PRO:DNx]
comment: Category=organism-gene.
synonym: "Emt" RELATED Gene-based [UniProtKB:Q03526]
synonym: "Itk" RELATED Gene-based [UniProtKB:Q03526]
synonym: "Tlk" RELATED Gene-based [UniProtKB:Q03526]
synonym: "Tsk" RELATED Gene-based [UniProtKB:Q03526]
synonym: "mITK" EXACT PRO-short-label [PRO:DNx]
synonym: "kinase EMT (mouse)" EXACT [UniProtKB:Q03526]
synonym: "kinase TLK (mouse)" EXACT [UniProtKB:Q03526]
synonym: "T-cell-specific kinase (mouse)" EXACT [UniProtKB:Q03526]
synonym: "IL-2-inducible T-cell kinase (mouse)" EXACT [UniProtKB:Q03526]
xref: UniProtKB:Q03526
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002111 ! tyrosine-protein kinase ITK/TSK
relationship: has_gene_template MGI:96621 ! Itk (mouse)

[Term]
id: PR:000002239
name: tyrosine-protein kinase ITK/TSK isoform 2
def: "A tyrosine-protein kinase ITK/TSK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08881-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "ITK/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002111 ! tyrosine-protein kinase ITK/TSK

[Term]
id: PR:000002238
name: tyrosine-protein kinase ITK/TSK isoform 1
def: "A tyrosine-protein kinase ITK/TSK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03526-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "ITK/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002111 ! tyrosine-protein kinase ITK/TSK

[Term]
id: PR:P08630
name: tyrosine-protein kinase Btk29A (fruit fly)
def: "A tyrosine-protein kinase ITK/TSK that is encoded in the genome of fruit fly." [PRO:WCB]
comment: Category=organism-gene.
synonym: "Src2" RELATED Gene-based [UniProtKB:P08630]
synonym: "Tec29" RELATED Gene-based [UniProtKB:P08630]
synonym: "Btk29A" RELATED Gene-based [UniProtKB:P08630]
synonym: "CG8049" RELATED Gene-based [UniProtKB:P08630]
synonym: "Src29A" RELATED Gene-based [UniProtKB:P08630]
synonym: "fly-ITK" EXACT PRO-short-label [PRO:DNx]
synonym: "Dsrc28C (fruit fly)" EXACT [UniProtKB:P08630]
synonym: "Dsrc29a (fruit fly)" EXACT [UniProtKB:P08630]
xref: UniProtKB:P08630
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000002111 ! tyrosine-protein kinase ITK/TSK
relationship: has_gene_template FlyBase:FBgn0003502 ! Btk29A (fruit fly)