[Term]
id: PR:000037482
name: tyrosine-protein kinase BTK phosphorylated 1 (mouse)
def: "A tyrosine-protein kinase BTK (mouse) that is phosphorylated on two Tyr residues. Site 1 is a Tyr within the Src homology type 1 (SH1) domain and is transphosphorylated by a Src family tyrosine kinase. Site 2 is an autophosphorylation site within the Btk SH3 domain. UniProtKB:P35991, Tyr-223/Tyr-551, MOD:00048." [PMID:9326643]
comment: Category=organism-modification. Note: Activation of Btk correlates with an increase in the phosphorylation of two regulatory Btk tyrosine residues.
synonym: "active BTK" RELATED []
synonym: "mBTK/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35991, Tyr-223/Tyr-551, MOD:00048" EXACT PRO-proteoform-std [PRO:DAN]
is_a: PR:P35991 ! tyrosine-protein kinase BTK (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P35991-1
name: tyrosine-protein kinase BTK isoform 1 (mouse)
def: "A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mBTK/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P35991-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002236 ! tyrosine-protein kinase BTK isoform 1

[Term]
id: PR:000002110
name: tyrosine-protein kinase BTK
def: "A TEC-type tyrosine-protein kinase that is a translation product of the human BTK gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "ATK" RELATED Gene-based []
synonym: "BPK" RELATED Gene-based []
synonym: "BTK" EXACT PRO-short-label [PRO:DNx]
synonym: "AGMX1" RELATED Gene-based []
synonym: "kinase EMB" EXACT []
synonym: "bruton tyrosine kinase" EXACT []
synonym: "B-cell progenitor kinase" EXACT []
synonym: "agammaglobulinemia tyrosine kinase" EXACT []
synonym: "agammaglobulinaemia tyrosine kinase" EXACT []
xref: IUPHARobj:1948
xref: PIRSF:PIRSF500765
is_a: PR:000001967 ! TEC-type tyrosine-protein kinase

[Term]
id: PR:P35991
name: tyrosine-protein kinase BTK (mouse)
def: "A tyrosine-protein kinase BTK that is encoded in the genome of mouse." [OMA:P35991, PRO:WCB]
comment: Category=organism-gene.
synonym: "Bpk" RELATED Gene-based [UniProtKB:P35991]
synonym: "Btk" RELATED Gene-based [UniProtKB:P35991]
synonym: "mBTK" EXACT PRO-short-label [PRO:DNx]
synonym: "ATK (mouse)" EXACT [UniProtKB:P35991]
synonym: "kinase EMB (mouse)" EXACT [UniProtKB:P35991]
synonym: "bruton tyrosine kinase (mouse)" EXACT [UniProtKB:P35991]
synonym: "B-cell progenitor kinase (mouse)" EXACT [UniProtKB:P35991]
synonym: "agammaglobulinemia tyrosine kinase (mouse)" EXACT [UniProtKB:P35991]
xref: UniProtKB:P35991
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002110 ! tyrosine-protein kinase BTK
relationship: has_gene_template MGI:88216 ! Btk (mouse)